Nicorette Quickmist Cool Berry (Nicotine)

Nicotine, delivered via Nicorette Quickmist Cool Berry, is used in nicotine replacement therapy to support smoking cessation.

• Smoking cessation: provides rapid nicotine delivery to reduce cravings and withdrawal symptoms during quit attempts.
• Tobacco dependence: supplies a controlled dose of nicotine to help transition away from cigarettes.
• Relapse prevention: supports former smokers by offering a substitute nicotine source to maintain abstinence.

• Nicotine acts as an agonist at nicotinic acetylcholine receptors in the central nervous system. When administered as an oromucosal spray, nicotine is absorbed through the oral mucosa, producing plasma nicotine levels that mimic those from smoking, thereby reducing the intensity of withdrawal symptoms and cravings associated with nicotine dependence.

Nicotine replacement therapy may cause a range of adverse reactions.

Common Side Effects

• Throat irritation: mild discomfort or soreness in the throat.
• Mouth irritation: tingling or burning sensation in the oral cavity.
• Cough: transient coughing after spray use.
• Nausea: feeling of queasiness, especially with higher exposure.
• Headache: mild to moderate headache.
• Dizziness: light‑headed sensation.

Serious or Rare Side Effects

• Allergic reaction: rash, swelling, or difficulty breathing.
• Chest pain: unexpected discomfort or pressure in the chest.
• Rapid heartbeat: palpitations or tachycardia.
• Severe skin irritation: localized redness or swelling at the site of contact.
• Seizure: rare occurrence, particularly in patients with pre‑existing seizure disorders.

When using Nicorette Quickmist Cool Berry, consider the following precautions.

• Pregnancy: consult a healthcare professional before use.
• Breastfeeding: discuss potential risks with a provider.
• Cardiovascular disease: use with caution and monitor heart rate.
• Asthma or respiratory conditions: monitor for increased irritation.
• Age restriction: not intended for children under 12 years of age.
• Store at ambient temperature: keep in the original container, protect from moisture and heat.

Nicotine may interact with other medicines; awareness of potential interactions is important.

Major Interactions (Avoid)

• Monoamine oxidase inhibitors (MAOIs): may increase risk of hypertensive crisis.
• Other nicotine replacement products: risk of nicotine overdose.
• Certain antidepressants (e.g., bupropion): combined use may raise seizure risk.

Moderate Interactions (Monitor Closely)

• Caffeine: may enhance stimulant effects such as jitteriness.
• Alcohol: may increase nicotine cravings and affect metabolism.
• Beta‑blockers: may mask nicotine‑induced tachycardia, requiring careful monitoring.