Product image of Nicoril (Nicorandil) supplied by GNH India

Nicoril

Active Ingredient:
Nicorandil
Origin:
EU

Nicoril (Nicorandil)

Nicorandil, the active ingredient in Nicoril, is a nitrate vasodilator and ATP‑sensitive potassium channel opener presented as an oral dosage form for oral use. It is employed to relieve chest pain associated with angina pectoris in adult patients.

GNH India supplies Nicoril as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution.

Manufacturer / TM Owner

Rivopharm Uk Ltd

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Indications & Clinical Uses

Nicoril is an anti‑anginal agent that acts on coronary blood flow and cardiac workload.

  • Stable angina: reduces the frequency and severity of chest pain episodes.
  • Chronic angina: improves exercise tolerance and quality of life.
  • Ischemic heart disease: helps prevent angina attacks by lowering cardiac preload and afterload.

How It Works

  • Nicorandil releases nitric oxide, which activates guanylate cyclase and increases cyclic GMP, causing vascular smooth‑muscle relaxation. Simultaneously, it opens ATP‑sensitive potassium channels in cardiac and vascular tissue, leading to hyperpolarisation and further vasodilation of coronary and peripheral vessels, thereby decreasing cardiac preload and afterload.

Side Effects

Nicoril may cause a range of adverse reactions.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness.
  • Dizziness or light‑headedness.
  • Nausea or dyspepsia.
  • Hypotension: especially after the first dose.
  • Tachycardia: compensatory increase in heart rate.

Serious or Rare Side Effects

  • Severe hypotension: can lead to syncope.
  • Myocardial infarction: rare but reported.
  • Allergic reactions: rash, pruritus, or urticaria.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Worsening angina or coronary spasm.
  • Hepatic dysfunction: elevated liver enzymes.

Precautions & Warnings

Before initiating Nicoril, consider the following safety measures.

  • Blood pressure monitoring: check for hypotension before and during therapy.
  • Concomitant nitrate use: avoid combined use to prevent excessive vasodilation.
  • PDE‑5 inhibitors: do not co‑administer with sildenafil, tadalafil, or similar agents.
  • Liver function: assess baseline hepatic enzymes in patients with liver disease.
  • Asthma or COPD: use cautiously as potassium channel opening may affect bronchial tone.
  • Store at ambient temperature below 25 °C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Nicoril can interact with several drug classes; awareness helps minimise risk.

Major Interactions (Avoid)

  • Other nitrates (e.g., nitroglycerin): additive vasodilatory effect leading to severe hypotension.
  • Phosphodiesterase‑5 inhibitors (sildenafil, tadalafil): risk of profound blood pressure drop.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (ACE inhibitors, ARBs, calcium channel blockers): may enhance blood‑pressure‑lowering effect.
  • Diuretics: increase the likelihood of orthostatic hypotension.
  • Beta‑blockers: combined effect on heart rate and contractility may require dose adjustment.

Frequently Asked Questions

Nicoril contains nicorandil and is indicated for the symptomatic treatment of angina pectoris. It helps to relieve chest pain by improving blood flow to the heart muscle and reducing the workload on the heart.

Nicorandil acts through two complementary mechanisms: it donates nitric oxide, which relaxes vascular smooth muscle via the cyclic GMP pathway, and it opens ATP‑sensitive potassium channels, causing hyperpolarisation and further vasodilation of coronary and peripheral vessels.

The prescribed dose of Nicoril is individualized by the treating physician based on the severity of angina, patient response, and tolerability. The prescriber determines the appropriate starting dose and any subsequent adjustments.

Safety data for nicorandil in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Nicoril, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nicoril combines nitrate‑mediated vasodilation with potassium‑channel activation, offering a dual mechanism not found in classic nitrates or beta‑blockers. This can provide additional symptom control for patients who remain symptomatic on a single‑class therapy, though individual response varies.

Store Nicoril at ambient temperature below 25 °C in its original container, protected from moisture and direct sunlight. Keep the product out of reach of children and do not use if the packaging is damaged.

Nicoril is taken orally, usually with a glass of water. It may be taken with or without food, but patients should follow the specific instructions provided by their prescriber to optimise absorption and minimise side effects.

Serious adverse events include severe hypotension, myocardial infarction, life‑threatening allergic reactions such as Stevens‑Johnson syndrome, and hepatic dysfunction. Patients should seek immediate medical attention if they experience fainting, chest pain worsening, rash, or jaundice.

Nicoril is contraindicated in patients with severe hypotension, recent myocardial infarction, known hypersensitivity to nicorandil or other nitrates, and in those concurrently using phosphodiesterase‑5 inhibitors. Caution is also advised for patients with significant liver disease or uncontrolled asthma.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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