Product image of Nicotinamid Axicur (Nicotinamide) supplied by GNH India

Nicotinamid Axicur

Active Ingredient:
Nicotinamide
Origin:
EU

Nicotinamid Axicur (Nicotinamide)

Nicotinamide, the active ingredient in Nicotinamid Axicur, is a Vitamin B3 (niacinamide) presented as an oral nutritional supplement for systemic use. It helps prevent niacin deficiency, supports skin health, and contributes to general nutritional needs in adults and children. The product is formulated for oral administration and is available over the counter in the European Union.
GNH India supplies Nicotinamid Axicur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to Good Distribution Practice and provides regulatory documentation for global procurement.

Manufacturer / TM Owner

Axicorp Pharma Gmbh

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Indications & Clinical Uses

Nicotinamide is used as a Vitamin B3 supplement to address conditions related to niacin deficiency and skin health.

  • Pellagra prevention: helps maintain adequate niacin levels, reducing the risk of dermatitis, diarrhea and dementia associated with deficiency.
  • Skin health support: contributes to normal keratinocyte function and barrier integrity, promoting a healthy complexion and reducing inflammation.
  • General nutritional supplementation: provides an essential B‑vitamin for metabolic pathways, supporting energy production and DNA repair in the overall diet.
  • Cellular energy metabolism: enhances NAD+ availability, supporting mitochondrial function and cellular energy production.

How It Works

  • Nicotinamide serves as a precursor for the synthesis of nicotinamide adenine dinucleotide (NAD+), a co‑enzyme essential for cellular redox reactions, DNA repair, and energy metabolism. By entering the salvage pathway, it is converted to NAD+ and NADP+, supporting enzymatic activities across multiple tissues without causing the vasodilatory flushing associated with nicotinic acid. This increase in intracellular NAD+ levels enhances mitochondrial function and promotes the activity of sirtuins involved in cellular longevity.

Side Effects

Oral nicotinamide is generally well tolerated, but some users may experience adverse reactions.

Common Side Effects

  • Nausea: mild stomach upset after ingestion.
  • Headache: transient head discomfort.
  • Gastrointestinal discomfort: including abdominal cramps or diarrhea.
  • Skin irritation: mild rash or itching at the site of contact.

Serious or Rare Side Effects

  • Hepatotoxicity: elevated liver enzymes or liver injury in susceptible individuals.
  • Severe allergic reaction: anaphylaxis, swelling of face or throat.
  • Blood disorders: rare cases of thrombocytopenia or leukopenia.
  • Metabolic acidosis: very high doses may lead to acid‑base disturbances.

Precautions & Warnings

When considering nicotinamide supplementation, several safety considerations should be observed.

  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: discuss potential risks with a physician.
  • Liver disease: monitor hepatic function during prolonged use.
  • Kidney disease: assess renal function and adjust dosage if necessary.
  • Drug interactions: review concomitant medications for possible interactions.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nicotinamide may interact with certain medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Isoniazid: combined use can increase risk of liver toxicity.
  • Anticoagulants (e.g., warfarin): may enhance anticoagulant effect, requiring monitoring.

Moderate Interactions (Monitor Closely)

  • Anticonvulsants (e.g., carbamazepine, phenobarbital): may lower nicotinamide levels, reducing its effectiveness.
  • Chemotherapeutic agents (e.g., methotrexate): potential for additive hepatotoxicity.
  • Statins: possible increased risk of liver enzyme elevation.
  • Oral contraceptives: may slightly alter nicotinamide metabolism.

Frequently Asked Questions

Nicotinamid Axicur contains nicotinamide, a form of vitamin B3 that is used to prevent niacin deficiency (pellagra), support healthy skin, and provide general nutritional supplementation as part of a balanced diet.

Nicotinamide acts as a precursor for NAD+ and NADP+, co‑enzymes that are essential for cellular energy production, DNA repair, and many metabolic pathways. By increasing intracellular NAD+ levels, it supports mitochondrial function and the activity of enzymes involved in cellular health.

The appropriate dose of Nicotinamid Axicur is determined by a qualified healthcare professional based on the individual’s age, health status, and specific nutritional needs. Prescribers tailor the regimen to achieve the desired therapeutic effect while minimizing any potential risk.

Safety data for nicotinamide in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the use of Nicotinamid Axicur with their physician to weigh potential benefits against any uncertain risks.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nicotinamid Axicur provides nicotinamide, which does not cause the flushing associated with nicotinic acid (another vitamin B3 form). It is preferred when a non‑flushing option is needed, while still delivering the same nutritional benefits and supporting NAD+ synthesis.

Store Nicotinamid Axicur at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Nicotinamid Axicur is taken orally, usually with water. It can be taken with or without food, unless the prescribing clinician advises otherwise. Follow the administration instructions provided by the healthcare professional.

Serious risks, although rare, include liver injury manifested by elevated liver enzymes or hepatitis, severe allergic reactions such as anaphylaxis, and hematologic abnormalities like thrombocytopenia. Patients should seek medical attention if they notice signs of liver dysfunction, rash, swelling, or unusual bleeding.

Individuals with known hypersensitivity to nicotinamide or any excipients in the formulation should avoid the product. Persons with severe liver disease, uncontrolled renal impairment, or those taking medications that may interact significantly (e.g., isoniazid) should consult a healthcare provider before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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