Nicotinamide Renaudin (Nicotinamide)

Nicotinamide is used primarily to address niacin deficiency and to support cellular energy pathways.

• Niacin (vitamin B3) deficiency: restores normal niacin levels, preventing pellagra and related symptoms.
• Cellular energy metabolism support: increases NAD+ and NADP+ precursors, aiding redox reactions and ATP production.
• Post‑operative nutritional support: provides rapid vitamin B3 repletion when oral intake is limited.
• Skin health maintenance: contributes to keratinocyte function and may improve barrier integrity.
• Neurological function support: serves as a cofactor in neuronal NAD+ synthesis, potentially supporting nerve health.

• Nicotinamide acts as a precursor in the biosynthesis of the coenzymes nicotinamide adenine dinucleotide (NAD+) and its phosphorylated form NADP+. After cellular uptake, it is converted via the salvage pathway to NAD+, which participates in redox reactions, DNA repair, and signaling processes. By replenishing NAD+ pools, nicotinamide supports metabolic enzymes and energy production. The increased NAD+ availability also enhances activity of sirtuin enzymes, which regulate mitochondrial function and stress responses.

Injection of nicotinamide may be associated with several adverse reactions, ranging from mild to serious.

Common Side Effects

• Injection site pain or erythema: mild discomfort or redness at the site of administration.
• Nausea or vomiting: transient gastrointestinal upset.
• Headache: mild to moderate intensity.
• Flushing: brief warmth or redness, less common than with nicotinic acid.
• Dizziness: transient sensation of lightheadedness.
• Pruritus: mild itching at or away from injection site.

Serious or Rare Side Effects

• Hypersensitivity reactions: rash, pruritus, bronchospasm, or anaphylaxis requiring immediate medical attention.
• Severe hepatic dysfunction: elevated transaminases or jaundice in susceptible individuals.
• Metabolic