Nicorette Fruits Sans Sucre, Édulcorée Au Xylitol Et À L'acésulfame Potassique (Nicotine)

Nicotine, delivered via Nicorette, is used in nicotine replacement therapy to aid smoking cessation.

• Smoking cessation: helps adult smokers reduce cravings and withdraw from nicotine.
• Nicotine dependence: supports gradual reduction of nicotine intake in individuals attempting to quit.
• Relapse prevention: assists former smokers in maintaining abstinence during the early quit phase.

• Nicotine acts as a partial agonist at neuronal nicotinic acetylcholine receptors (nAChRs) in the central nervous system. By binding to these receptors, it provides a controlled level of stimulation that mimics the effect of tobacco‑derived nicotine, thereby reducing withdrawal symptoms and cravings while allowing the brain to adapt to lower nicotine exposure over time. The gradual tapering of nicotine exposure helps re‑establish normal receptor sensitivity and diminishes the reinforcing properties of smoking.

Nicotine replacement therapy may be associated with a range of adverse reactions, varying in frequency and severity.

Common Side Effects

• Mouth irritation: mild soreness or tingling in the oral cavity.
• Nausea: transient feeling of queasiness.
• Headache: mild to moderate headache.
• Dyspepsia: indigestion or stomach discomfort.
• Hiccups: occasional involuntary diaphragmatic contractions.
• Dry mouth: reduced salivation.

Serious or Rare Side Effects

• Cardiovascular events: chest pain, palpitations, or hypertension.
• Severe allergic reaction: rash, itching, swelling, or difficulty breathing.
• Persistent dizziness: prolonged vertigo not resolving with rest.
• Mood changes: depression or anxiety worsening.
• Overdose symptoms: vomiting, rapid heart rate, or seizures.
• Severe hypotension: sudden drop in blood pressure.

When using Nicorette lozenges, several precautions should be observed to ensure safe and effective therapy.

• Contraindication: avoid use in patients with recent myocardial infarction or unstable angina.
• Age restriction: not recommended for individuals under 18 years of age.
• Pregnancy and lactation: consult a healthcare professional before use during pregnancy or breastfeeding.
• Concomitant nicotine sources: do not combine with other nicotine‑containing products to prevent excess exposure.
• Adverse reaction monitoring: seek medical attention if experiencing persistent cardiovascular symptoms or severe allergic reactions.
• Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture and direct sunlight.

Nicotine may interact with other medicines, altering their effects or increasing the risk of adverse events.

Major Interactions (Avoid)

• Monoamine oxidase inhibitors (MAOIs): increased risk of hypertensive crisis.
• Beta‑blockers: may blunt the cardiovascular response to nicotine, complicating blood pressure control.

Moderate Interactions (Monitor Closely)

• Antidepressants (SSRIs, SNRIs): possible enhancement of side effects such as nausea or insomnia.
• Antihypertensive agents: nicotine can raise blood pressure, requiring dose adjustment.
• Caffeine‑containing products: may increase jitteriness or palpitations.
• Antidiabetic drugs: nicotine may affect glucose metabolism, necessitating closer monitoring.