Nicorette® Fruit & Mint Mundspray (Nicotine)

Nicotine, delivered via Nicorette® Fruit & Mint Mundspray, is used as a nicotine replacement therapy to support smoking cessation.

• Smoking cessation: Provides controlled nicotine to alleviate withdrawal and cravings, facilitating gradual reduction of cigarette use.
• Aid to quit smoking: Supports adults attempting to stop tobacco use by delivering a measured dose of nicotine.
• Tobacco dependence: Reduces dependence symptoms and helps maintain abstinence during the quitting process.

• Nicotine acts as an agonist at nicotinic acetylcholine receptors in the oral mucosa and central nervous system. The oromucosal spray delivers nicotine rapidly into the bloodstream, producing modest stimulation of these receptors, which diminishes the intensity of withdrawal symptoms and cravings that occur during nicotine abstinence.

Common Side Effects

• Mouth irritation or tingling: mild discomfort in the oral cavity after spraying.
• Throat irritation: transient soreness or tickle in the throat.
• Nausea: occasional feeling of queasiness.
• Dizziness: brief light‑headed sensation.

Serious or Rare Side Effects

• Allergic reaction: rash, itching, swelling, or difficulty breathing.
• Severe mouth ulceration: persistent sores or lesions.
• Cardiovascular events: increased blood pressure, chest pain, or arrhythmia.
• Severe nausea or vomiting: persistent and intense gastrointestinal upset.
• Unexplained weight loss: significant loss without dietary change.

Before using Nicorette® Fruit & Mint Mundspray, consider the following precautions.

• Assess nicotine dependence level: determine appropriate use based on smoking history.
• Allergy check: do not use if you have known hypersensitivity to nicotine or any excipients.
• Avoid concurrent nicotine products: using multiple nicotine sources can increase adverse effects.
• Pregnancy and breastfeeding: consult a healthcare professional before use.
• Cardiovascular disease: use with caution and under medical supervision.
• Store at room temperature: keep in the original container, protect from moisture and heat.

Nicotine may interact with several medicines; monitor accordingly.

Major Interactions (Avoid)

• Monoamine oxidase inhibitors (MAOIs): may increase hypertensive risk.
• Beta‑blockers: nicotine‑induced tachycardia may be masked.
• Insulin or oral hypoglycemics: nicotine can affect glucose control.

Moderate Interactions (Monitor Closely)

• Caffeine: may exacerbate jitteriness or insomnia.
• Alcohol: can increase nicotine cravings and affect metabolism.
• Antidepressants (SSRIs): monitor for mood changes or increased side effects.