Nicotine Menthe Sans Sucre À L’acésulfame Potassique Et À La Saccharine Alkalon (Nicotine)

Nicotine is used in nicotine replacement therapy to support smoking cessation by addressing nicotine dependence.

• Smoking cessation: helps adult smokers reduce withdrawal symptoms and cravings, facilitating gradual reduction of nicotine intake.
• Relapse prevention: supports individuals who have recently quit smoking to maintain abstinence.
• Nicotine dependence: reduces cravings during quit attempts.

• Nicotine acts as an agonist at neuronal nicotinic acetylcholine receptors, primarily the α4β2 subtype, stimulating dopamine release in the mesolimbic pathway. This mimics the pharmacologic effects of tobacco‑derived nicotine, thereby alleviating withdrawal symptoms and decreasing the urge to smoke while allowing a controlled reduction in nicotine exposure.

Nicotine replacement therapy can cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

• Nausea: mild stomach upset or queasiness.
• Mouth irritation: tingling or soreness in the oral cavity.
• Headache: mild to moderate headache.
• Dizziness: transient light‑headedness.
• Insomnia: difficulty falling or staying asleep.
• Increased salivation: excess saliva production.

Serious or Rare Side Effects

• Cardiovascular events: chest pain, palpitations, or hypertension.
• Severe allergic reaction: rash, itching, swelling, or difficulty breathing.
• Persistent nausea/vomiting: prolonged gastrointestinal distress.
• Mood changes: anxiety, irritability, or depression.
• Arrhythmias: irregular heart rhythm.
• Hypotension: unusually low blood pressure.

When using nicotine oral products, consider the following safety measures.

• Contraindication: avoid use in individuals with known hypersensitivity to nicotine or formulation excipients.
• Cardiovascular risk: assess patients with uncontrolled hypertension, recent myocardial infarction, or arrhythmias before initiating therapy.
• Pregnancy and lactation: discuss potential risks with a healthcare professional; use only if clearly indicated.
• Drug interactions: review concurrent medications that affect hepatic metabolism or cardiovascular function.
• Storage: Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Nicotine may interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

• Monoamine oxidase inhibitors (MAOIs): increased risk of hypertensive crisis.
• Beta‑blockers: may blunt nicotine‑induced tachycardia, complicating cardiovascular monitoring.
• Certain antidepressants (e.g., bupropion): heightened risk of seizures.

Moderate Interactions (Monitor Closely)

• CYP2A6 inhibitors (e.g., methoxsalen): may increase nicotine plasma levels.
• Antihypertensives: nicotine can counteract blood‑pressure‑lowering effects.
• Caffeine: combined use may exacerbate jitteriness or insomnia.