Product image of Nicotinell Cool Mint (Nicotine Polacrilex) supplied by GNH India

Nicotinell Cool Mint

Active Ingredient:
Nicotine Polacrilex
Origin:
EU

Nicotinell Cool Mint (Nicotine Polacrilex)

Nicotine Polacrilex, the active ingredient in Nicotinell Cool Mint, is a nicotine replacement therapy presented as a buccal lozenge for buccal use. It treats nicotine dependence and aids smoking cessation in adult smokers.
GNH India supplies Nicotinell Cool Mint as a licensed, GDP-compliant international pharmaceutical supplier serving pharmacies and clinics worldwide.

Manufacturer / TM Owner

Reddy Holding Gmbh

1
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Indications & Clinical Uses

  • Nicotinell Cool Mint, a nicotine replacement therapy, is used to support smoking cessation by delivering nicotine through the buccal mucosa.
  • Smoking cessation: helps reduce cravings and withdrawal symptoms in adults attempting to quit.
  • Tobacco dependence: provides controlled nicotine to facilitate gradual reduction of cigarette use.
  • Relapse prevention: supports maintenance of abstinence after initial quitting period.

How It Works

  • Nicotine Polacrilex is a polymer-bound nicotine complex that releases nicotine slowly when the lozenge dissolves in the mouth. The released nicotine binds to nicotinic acetylcholine receptors in the central nervous system, partially stimulating the same pathways activated by tobacco smoke, thereby alleviating withdrawal and reducing the urge to smoke.

Side Effects

Common Side Effects

  • Mouth irritation or tingling
  • Nausea or upset stomach
  • Hiccups or dyspepsia
  • Headache
  • Dizziness
  • Increased salivation

Serious or Rare Side Effects

  • Severe allergic reaction (rash, swelling, difficulty breathing)
  • Persistent mouth ulceration
  • Cardiovascular events (chest pain, arrhythmia)
  • Significant blood pressure changes
  • Severe hypotension
  • Unexplained fainting

Precautions & Warnings

Before using Nicotinell Cool Mint, consider the following precautions:

  • Cardiovascular assessment: evaluate history of heart disease or hypertension.
  • Medical supervision: use under guidance of a healthcare professional.
  • Recent myocardial infarction: avoid use within 4 weeks of a heart attack.
  • Non‑smokers: not indicated for individuals who do not smoke.
  • Oral health: do not use with active mouth ulcers or severe dental disease.
  • Store at room temperature: keep in the original pack, protect from moisture and keep out of reach of children.

Avoid Interactions

Nicotine can interact with several medicines, requiring attention to the following:

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors: may increase risk of hypertensive crisis.
  • Beta‑blockers: nicotine‑induced tachycardia may reduce therapeutic effect.

Moderate Interactions (Monitor Closely)

  • Insulin or oral hypoglycemics: nicotine may affect blood glucose control.
  • Antidepressants (SSRIs, SNRIs): monitor for mood changes.
  • Caffeine: nicotine may enhance stimulant effects, leading to jitteriness.
  • Alcohol: combined use may increase cardiovascular strain.

Frequently Asked Questions

Nicotinell Cool Mint is an over‑the‑counter nicotine replacement therapy formulated as a mint‑flavored buccal lozenge. It is intended to help adult smokers quit by reducing nicotine withdrawal symptoms and cravings during a quit attempt.

Nicotine Polacrilex is a polymer‑bound nicotine complex that releases nicotine slowly when the lozenge dissolves in the mouth. The nicotine then binds to nicotinic acetylcholine receptors in the brain, producing a mild stimulant effect that mimics the action of tobacco‑derived nicotine and eases withdrawal.

The prescriber determines the appropriate lozenge strength and frequency based on the individual’s smoking level. Typical regimens start with one lozenge every one to two hours, not exceeding the daily maximum recommended by the healthcare professional. Exact dosing must follow the prescriber’s instructions.

Safety in pregnancy and lactation has not been established; the product carries an unknown pregnancy category. Healthcare providers should weigh potential benefits against possible risks before recommending use to pregnant or nursing individuals.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with nicotine patches or gum, the lozenge offers rapid buccal absorption and a mint flavor that may improve compliance. It allows flexible dosing but can cause more oral irritation than patches. Choice depends on patient preference, tolerance and clinical considerations.

Store the lozenges at room temperature, below 25 °C, in the original container, protected from moisture and direct sunlight. Keep the product out of reach of children.

Place a lozenge between the gum and cheek and allow it to dissolve slowly without chewing or swallowing whole. Avoid eating or drinking for at least 15 minutes after placement to ensure optimal nicotine absorption.

Rare but serious reactions can include severe allergic responses such as rash, swelling or breathing difficulty, significant cardiovascular events like chest pain or arrhythmia, and persistent mouth ulceration. Any of these symptoms require immediate medical attention.

People who are not current smokers, those with recent myocardial infarction, uncontrolled hypertension, severe oral lesions, or known hypersensitivity to nicotine or any excipients should avoid using this product. Consultation with a healthcare professional is essential before starting.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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