Product image of Nicotinell Drop (Nicotine Polacrilex) supplied by GNH India

Nicotinell Drop

Active Ingredient:
Nicotine Polacrilex
Origin:
EU

Nicotinell Drop (Nicotine Polacrilex)

Nicotine Polacrilex, the active ingredient in Nicotinell Drop, is a nicotine replacement therapy presented as a buccal drop for buccal administration. It is intended for adult smokers who are attempting to quit and works by delivering controlled nicotine to alleviate withdrawal symptoms and cravings associated with smoking cessation. The product complies with EU regulatory standards and is available over the counter across European pharmacies.

GNH India supplies Nicotinell Drop as a licensed, GDP‑compliant international pharmaceutical supplier serving pharmacies and clinics worldwide, providing reliable sourcing for healthcare providers seeking quality nicotine replacement products.

Manufacturer / TM Owner

Reddy Holding Gmbh

1
Pack/s
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Indications & Clinical Uses

  • Nicotinell Drop, a nicotine replacement therapy, is used to support smoking cessation by addressing nicotine dependence.
  • Smoking cessation: helps adult smokers reduce cravings and withdraw from nicotine.
  • Tobacco dependence: provides controlled nicotine to ease the transition away from cigarettes.
  • Nicotine withdrawal: alleviates symptoms such as irritability, anxiety, and restlessness.

How It Works

  • Nicotine Polacrilex acts as an agonist at nicotinic acetylcholine receptors in the central nervous system. When administered buccally, the nicotine is absorbed through the oral mucosa, producing plasma nicotine concentrations that mimic those of smoking, thereby reducing withdrawal symptoms and cravings associated with nicotine dependence.

Side Effects

Common Side Effects

  • Mouth irritation or soreness
  • Throat irritation or dryness
  • Nausea or upset stomach
  • Hiccups or transient dizziness
  • Altered taste perception
  • Mild headache

Serious or Rare Side Effects

  • Allergic reactions such as rash, angioedema, or anaphylaxis
  • Severe mouth ulceration or mucosal lesions
  • Cardiovascular events including hypertension or arrhythmia
  • Respiratory difficulty or bronchospasm

Precautions & Warnings

  • Before using Nicotinell Drop, consider the following precautions.
  • Assess nicotine dependence: evaluate the patient’s smoking history and level of dependence.
  • Avoid use in children: product is not intended for persons under 18 years of age.
  • Do not use if allergic: contraindicated in individuals with known hypersensitivity to nicotine or formulation excipients.
  • Monitor cardiovascular status: use with caution in patients with hypertension, coronary artery disease, or arrhythmias.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nicotinell Drop may interact with other medicines. Review the following interactions.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): may increase risk of hypertensive crisis.
  • CYP2A6 inhibitors: can alter nicotine metabolism and increase systemic exposure.
  • Concurrent nicotine replacement products: risk of nicotine overdose.

Moderate Interactions (Monitor Closely)

  • Selective serotonin reuptake inhibitors (SSRIs): may increase nausea.
  • Antihypertensive agents: nicotine may reduce their efficacy, requiring blood pressure monitoring.

Frequently Asked Questions

Nicotinell Drop is used as a nicotine replacement therapy to help adult smokers quit by reducing cravings and alleviating withdrawal symptoms associated with smoking cessation.

Nicotine polacrilex is a nicotinic acetylcholine receptor agonist. When delivered buccally, it releases nicotine that is absorbed through the oral mucosa, providing plasma nicotine levels that mimic smoking and thereby lessen withdrawal and cravings.

The appropriate dose is determined by the prescribing healthcare professional based on the individual’s smoking history, level of dependence, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for nicotine polacrilex in pregnancy and lactation are limited. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and only under medical supervision.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with nicotine patches or gum, Nicotinell Drop offers rapid buccal absorption, allowing flexible dosing and quicker relief of cravings. Unlike patches, it does not provide a steady plasma level, and unlike gum, it does not require chewing, which some users prefer.

Store Nicotinell Drop at ambient temperature, below 25 °C, in its original container. Keep it away from moisture, direct sunlight, and heat sources to maintain product stability.

The drop is placed onto the buccal mucosa (inner cheek) and allowed to absorb without swallowing immediately. Users should avoid eating or drinking for a few minutes after administration to ensure optimal absorption.

Serious risks include allergic reactions such as rash, angioedema, or anaphylaxis, severe mouth ulceration, and cardiovascular events like hypertension or arrhythmia. Any signs of these conditions require immediate medical attention.

Individuals with known hypersensitivity to nicotine or any component of the formulation, children under 18 years of age, and patients with uncontrolled cardiovascular disease should avoid using Nicotinell Drop unless advised otherwise by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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