Nicotinell Fruit (Nicotine Polacrilex)

Nicotinell Fruit is a nicotine replacement product that acts on the nicotine dependence pathway to support quitting smoking.

• Smoking cessation: provides controlled nicotine to reduce cravings and support gradual cessation.
• Nicotine withdrawal relief: eases symptoms such as irritability, anxiety, and difficulty concentrating.
• Harm reduction: offers a less harmful source of nicotine compared with combustible tobacco.

• Nicotine Polacrilex releases nicotine through buccal absorption, where it binds as a partial agonist to nicotinic acetylcholine receptors in the central nervous system. This activation mitigates withdrawal by delivering a steady, lower dose of nicotine, decreasing the intensity of cravings while allowing receptor desensitization over time.

Adverse reactions may occur with buccal nicotine delivery. Most are mild and transient.

Common Side Effects

• Mouth irritation: soreness or tingling at the site of placement.
• Throat discomfort: mild scratchy feeling.
• Nausea: occasional queasiness.
• Headache: mild to moderate.
• Increased salivation: excess drooling.
• Indigestion: mild stomach upset.

Serious or Rare Side Effects

• Allergic reaction: rash, swelling, or difficulty breathing.
• Persistent hypertension: elevated blood pressure not related to baseline.
• Cardiac arrhythmia: irregular heartbeat.
• Severe nausea/vomiting: leading to dehydration.
• Oral ulceration: painful sores that do not heal.
• Chest pain: unexplained discomfort requiring medical evaluation.

Before using Nicotinell Fruit, consider the following safety measures.

• Cardiovascular disease: assess risk as nicotine may increase heart rate and blood pressure.
• Pregnancy and lactation: consult a healthcare professional before use.
• Diabetes: monitor blood glucose as nicotine can affect glycemic control.
• Psychiatric conditions: use with caution in patients with anxiety or mood disorders.
• Concomitant nicotine products: avoid using multiple nicotine sources simultaneously.
• Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Nicotinell Fruit may interact with other medicines; awareness of interaction severity helps guide safe use.

Major Interactions (Avoid)

• Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
• Certain antihypertensives: nicotine may counteract blood‑pressure‑lowering effects.

Moderate Interactions (Monitor Closely)

• Antidepressants (SSRIs, SNRIs): monitor for increased anxiety or insomnia.
• Antidiabetic agents: observe for altered glucose levels.
• Caffeine‑containing products: potential for heightened stimulant effects.
• Other nicotine replacement therapies: avoid overlapping dosing to prevent nicotine toxicity.
• Herbal supplements (e.g., St. John’s wort): may affect nicotine metabolism.