Nicotinell Fruit (Nicotine Polacrilex)

Nicotinell Fruit provides nicotine polacrilex as a nicotine replacement therapy, targeting tobacco dependence and supporting cessation efforts.

• Smoking cessation: reduces cravings and withdrawal symptoms to aid quitting tobacco use.
• Relapse prevention: supports maintaining abstinence after initial quitting by providing controlled nicotine exposure.

• Nicotine Polacrilex releases nicotine through buccal absorption, where it binds as a partial agonist to nicotinic acetylcholine receptors in the central nervous system. This activation partially stimulates the receptors, mitigating the deficit caused by tobacco abstinence and thereby decreasing withdrawal intensity and craving frequency.

Common Side Effects

• Mouth irritation: mild soreness or tingling in the oral cavity.
• Nausea: transient feeling of queasiness after use.
• Increased salivation: excess saliva production during chewing.
• Dyspepsia: occasional indigestion or stomach discomfort.
• Taste disturbance: altered perception of flavors.
• Hiccups: brief, involuntary diaphragm contractions.

Serious or Rare Side Effects

• Allergic reaction: rash, itching, or swelling indicating hypersensitivity.
• Throat swelling: edema that may compromise airway.
• Chest pain: unexplained discomfort requiring medical evaluation.
• Irregular heartbeat: palpitations or arrhythmia.
• Severe skin rash: widespread erythema or blistering.
• Anaphylaxis: rare, life‑threatening systemic reaction.

Before initiating therapy, consider the following precautions:

• Assess nicotine dependence: evaluate the level of addiction to tailor duration of use.
• Allergy screening: avoid if known hypersensitivity to nicotine or formulation excipients.
• Cardiovascular risk: do not use in patients with recent myocardial infarction or unstable angina.
• Hypertension monitoring: use with caution in uncontrolled high blood pressure.
• Duration limit: adhere to recommended treatment length to prevent prolonged nicotine exposure.
• Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Nicotine Polacrilex may interact with several medication classes.

Major Interactions (Avoid)

• Monoamine oxidase inhibitors: increased risk of hypertensive crisis.
• Beta‑blockers: nicotine may mask tachycardia, complicating cardiovascular monitoring.
• Insulin: nicotine can alter glucose metabolism, affecting insulin requirements.

Moderate Interactions (Monitor Closely)

• Caffeine: combined stimulant effect may increase nervousness.
• Antidepressants: monitor for mood changes or heightened side effects.
• Antihypertensives: nicotine may reduce blood‑pressure‑lowering efficacy.