Nicotinell Fruit (Nicotine Polacrilex)

Nicotine Polacrilex is used in nicotine replacement therapy to support smoking cessation.

• Smoking cessation: provides controlled nicotine delivery to lessen cravings and withdrawal symptoms.
• Tobacco dependence: assists adults in transitioning away from regular cigarette use.
• Nicotine dependence: helps manage nicotine withdrawal during quit attempts.

• Nicotine Polacrilex is a nicotine salt complex that releases nicotine gradually when placed in the buccal cavity. The nicotine binds to nicotinic acetylcholine receptors in the central nervous system, partially stimulating them and thereby reducing the intensity of withdrawal and craving signals associated with abrupt cessation of smoking.

Adverse reactions may occur with buccal nicotine lozenges. Most are mild and reversible.

Common Side Effects

• Mouth irritation: soreness or tingling in the oral mucosa.
• Throat irritation: mild discomfort or scratchiness.
• Nausea: transient feeling of queasiness.
• Hiccups: brief, involuntary diaphragmatic contractions.
• Increased salivation: excess saliva production.
• Dyspepsia: mild indigestion or stomach upset.

Serious or Rare Side Effects

• Allergic reaction: rash, itching, or swelling.
• Chest pain: unexplained discomfort in the chest area.
• Irregular heartbeat: palpitations or arrhythmia.
• Severe mouth ulcer: large or persistent ulceration.
• Anaphylaxis: severe, life‑threatening allergic response.
• Severe dizziness: pronounced vertigo or loss of balance.

Before using Nicotinell Fruit, consider the following safety measures.

• Assess nicotine dependence level: determine the appropriate strength based on smoking history.
• Allergy check: avoid if known hypersensitivity to nicotine or formulation excipients.
• Cardiovascular risk: do not use immediately after recent myocardial infarction or unstable angina.
• Hypertension caution: monitor blood pressure as nicotine may cause transient elevation.
• Concomitant nicotine products: do not combine with other nicotine replacement therapies.
• Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Nicotinell Fruit may interact with other medicines; monitor as indicated.

Major Interactions (Avoid)

• Monoamine oxidase inhibitors (MAOIs): may amplify nicotine’s cardiovascular effects.
• CYP2A6 inhibitors: can increase systemic nicotine concentrations.

Moderate Interactions (Monitor Closely)

• Selective serotonin reuptake inhibitors (SSRIs): may alter nicotine metabolism.
• Beta‑blockers: nicotine‑induced tachycardia may be masked.
• Antihypertensives: nicotine may reduce the efficacy of blood‑pressure‑lowering drugs.