Nicotinell Fruit (Nicotine Polacrilex)

Nicotinell Fruit, a nicotine replacement therapy, is used to support smoking cessation by delivering nicotine through the buccal mucosa.

• Smoking cessation: helps adult smokers reduce cravings and manage withdrawal symptoms while quitting.
• Tobacco dependence: provides a controlled nicotine dose to facilitate gradual reduction of tobacco use.
• Nicotine withdrawal management: alleviates symptoms such as irritability, anxiety, and difficulty concentrating during the quitting process.

• Nicotine polacrilex is a nicotine salt bound to a polymer matrix that releases nicotine slowly when placed against the buccal mucosa. The released nicotine acts as a partial agonist at neuronal nicotinic acetylcholine receptors, stimulating them enough to diminish withdrawal symptoms but not producing the full reinforcement of smoking. This controlled stimulation helps the user transition away from combustible tobacco. The delivery provides nicotine over several hours, maintaining steady plasma levels.

Nicotinell Fruit may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

• Mouth irritation: mild soreness or tingling of the oral mucosa.
• Throat irritation: discomfort or scratchy feeling in the throat.
• Nausea: occasional feeling of queasiness after use.
• Increased salivation: excess saliva production in the mouth.
• Hiccups: brief involuntary diaphragm contractions.

Serious or Rare Side Effects

• Allergic reaction: rash, itching, swelling, or difficulty breathing.
• Severe mouth ulceration: painful sores that persist beyond normal use.
• Chest pain or palpitations: unusual cardiac sensations requiring medical attention.

When using Nicotinell Fruit, several precautions should be observed to ensure safe and effective use.

• Assess nicotine dependence: determine the appropriate strength and duration of therapy based on the individual’s smoking history.
• Avoid use in children and adolescents: the product is not intended for persons under 18 years of age.
• Do not combine with other nicotine products: concurrent use may lead to nicotine overdose.
• Monitor cardiovascular status: use with caution in patients with heart disease or hypertension.
• Consult healthcare professional if pregnant or breastfeeding: safety has not been established.
• Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Nicotinell Fruit can interact with certain medicines; awareness of these interactions helps prevent adverse effects.

Major Interactions (Avoid)

• Other nicotine replacement products: combined use may cause nicotine toxicity.
• Strong CYP2A6 inhibitors (e.g., methoxsalen): may increase nicotine plasma levels.
• Monoamine oxidase inhibitors: concurrent use may heighten cardiovascular stimulation.

Moderate Interactions (Monitor Closely)

• Beta‑blockers: nicotine may reduce their antihypertensive effectiveness.
• Anticoagulants (e.g., warfarin): nicotine can affect platelet function and clotting risk.
• Insulin or oral hypoglycemics: nicotine may alter glucose metabolism, requiring dose adjustments.