Nicotinell Fruit (Nicotine Polacrilex)

Nicotinell Fruit provides nicotine via the buccal route to support smoking cessation and related nicotine dependence.

• Smoking cessation: helps adult smokers manage cravings and withdrawal during quit attempts.
• Nicotine dependence: reduces the intensity of withdrawal symptoms in individuals trying to stop tobacco use.
• Tobacco addiction: assists in transitioning from cigarettes to a nicotine‑free state under medical guidance.

• Nicotine polacrilex releases nicotine in the oral cavity where it is absorbed through the buccal mucosa. The nicotine binds to nicotinic acetylcholine receptors in the central nervous system, partially stimulating the same pathways activated by cigarette smoking, thereby decreasing withdrawal symptoms and cravings while allowing gradual reduction of nicotine exposure.

Nicotinell Fruit may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

• Mouth irritation: mild soreness or tingling in the oral cavity.
• Hiccups: brief episodes of involuntary diaphragm contraction.
• Nausea: occasional upset stomach or feeling of queasiness.
• Throat irritation: scratchy sensation after use.
• Increased salivation: excess saliva production.
• Dyspepsia: mild indigestion or abdominal discomfort.

Serious or Rare Side Effects

• Allergic reaction: rash, itching, swelling, or difficulty breathing.
• Oral ulceration: painful sores in the mouth.
• Chest pain: unexpected discomfort in the chest area.
• Dizziness: feeling light‑headed or unsteady.
• Severe nausea or vomiting: persistent gastrointestinal upset.
• Arrhythmia: irregular heart rhythm, though very uncommon.

Before using Nicotinell Fruit, consider the following safety measures.

• Cardiovascular assessment: evaluate heart disease risk before initiating therapy.
• Medical supervision: use under guidance of a healthcare professional.
• Allergy check: avoid if known hypersensitivity to nicotine or excipients.
• Non‑smoker restriction: not intended for individuals who do not use tobacco.
• Child safety: keep out of reach of children and pets.
• Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Nicotinell Fruit can interact with certain medications, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

• Monoamine oxidase inhibitors (MAOIs): may increase risk of hypertensive crisis.
• Insulin: nicotine can affect blood glucose control, requiring dose adjustments.
• Warfarin: nicotine may alter anticoagulant effect, affecting INR stability.

Moderate Interactions (Monitor Closely)

• Caffeine: nicotine may enhance stimulant effects, leading to jitteriness.
• Alcohol: combined use can increase cardiovascular strain.
• Select antidepressants (e.g., SSRIs): may require monitoring for mood changes.