Nicotinell Fruit Sans Sucre (Nicotine Polacrilex)

• Nicotine polacrilex is used in nicotine replacement therapy to address tobacco‑related dependence.
• Smoking cessation: assists adult smokers in quitting by alleviating nicotine withdrawal symptoms and reducing cravings.
• Nicotine dependence: provides a controlled source of nicotine to replace cigarettes and help manage physiological dependence.
• Relapse prevention: supports individuals who have recently quit smoking to maintain abstinence and avoid relapse.

• Nicotine polacrilex is a resin‑bound nicotine complex that releases nicotine slowly when placed in the oral cavity. The released nicotine is absorbed through the buccal mucosa and binds to nicotinic acetylcholine receptors in the central nervous system, partially stimulating these receptors. This mimics the pharmacologic effect of tobacco‑derived nicotine, thereby decreasing the intensity of withdrawal symptoms and cravings while allowing the user to taper nicotine exposure over time.

Nicotinell Fruit Sans Sucre may cause a range of oral and systemic adverse reactions.

Common Side Effects

• Mouth irritation: mild soreness or tingling in the mouth.
• Increased salivation: excess saliva production.
• Nausea: feeling of queasiness.
• Dyspepsia: indigestion or stomach discomfort.
• Taste disturbance: altered or unpleasant taste.
• Hiccups: brief involuntary diaphragm contractions.

Serious or Rare Side Effects

• Throat ulceration: painful sores in the throat.
• Allergic reaction: rash, itching, swelling, or difficulty breathing.
• Respiratory distress: wheezing or shortness of breath.
• Severe mouth sores: extensive ulceration of oral mucosa.
• Anaphylaxis: life‑threatening systemic allergic response.

When using Nicotinell Fruit Sans Sucre, several precautions should be observed to ensure safe and effective therapy.

• Cardiovascular assessment: evaluate patients with recent heart disease before initiating therapy.
• Medical supervision: use under guidance of a healthcare professional.
• Non‑smoker restriction: not intended for individuals who do not currently smoke.
• Concomitant nicotine products: avoid using other nicotine replacement products simultaneously.
• Child safety: keep product out of reach of children and pets.
• Store at ambient temperature below 25°C: keep in original packaging, protect from moisture.

Nicotine can interact with several medicines, altering their effects or increasing adverse reactions.

Major Interactions (Avoid)

• Warfarin: nicotine may enhance anticoagulant effect, increasing bleeding risk.
• Insulin: nicotine can affect glucose metabolism, requiring dose adjustments.
• Theophylline: nicotine may increase plasma levels, raising toxicity potential.

Moderate Interactions (Monitor Closely)

• Antidepressants: nicotine may modify therapeutic response of certain SSRIs.
• Beta‑blockers: nicotine can reduce blood pressure‑lowering efficacy.
• Caffeine: nicotine may potentiate stimulant effects, leading to jitteriness.