Product image of Nictur (Desmopressin) supplied by GNH India

Nictur

Active Ingredient:
Desmopressin
Origin:
EU

Nictur (Desmopressin)

Desmopressin, the active ingredient in Nictur, is a vasopressin analog presented as an oral dosage form for oral use. It selectively stimulates renal V2 receptors to increase water reabsorption and reduce urine output, making it useful in several endocrine and bleeding disorders.
GNH India supplies Nictur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pls Pharma, Produtos Farmacêuticos Lda

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Indications & Clinical Uses

  • Desmopressin acts on the antidiuretic pathway and is employed for several well‑established conditions.
  • Central diabetes insipidus: reduces excessive urine volume by enhancing renal water reabsorption.
  • Nocturnal enuresis: decreases nighttime bedwetting episodes through antidiuretic action.
  • Hemophilia A (bleeding control): raises plasma factor VIII levels to aid hemostasis.
  • von Willebrand disease: improves von Willebrand factor release to control mucosal bleeding.

How It Works

  • Desmopressin is a synthetic analogue of vasopressin that binds selectively to V2 receptors on the basolateral membrane of renal collecting‑duct cells. Activation of these G‑protein‑coupled receptors stimulates adenylate cyclase, increasing intracellular cAMP, which promotes the insertion of aquaporin‑2 water channels into the apical membrane, thereby enhancing water reabsorption and concentrating urine.

Side Effects

Desmopressin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Nausea or abdominal discomfort.
  • Nasal congestion or rhinorrhea.
  • Hyponatremia (mild): low sodium levels detected in routine labs.
  • Flushing or warmth sensation.

Serious or Rare Side Effects

  • Severe hyponatremia leading to seizures or coma.
  • Water intoxication with rapid weight gain.
  • Allergic reactions such as rash, itching or angioedema.
  • Thrombotic events in patients with pre‑existing risk factors.

Precautions & Warnings

Before prescribing Nictur, clinicians should consider several safety factors.

  • Renal function: assess in patients with impaired kidney function.
  • Electrolytes: monitor serum sodium before and during therapy.
  • Fluid balance: advise patients to limit excessive water intake.
  • Concomitant drugs: review use of diuretics, NSAIDs or antidepressants.
  • Cardiovascular disease: use cautiously in uncontrolled hypertension.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Desmopressin can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Carbamazepine: induces metabolism, reducing desmopressin effect.
  • NSAIDs (e.g., ibuprofen): increase risk of hyponatremia.
  • Thiazide diuretics: potentiate water retention and hyponatremia.

Moderate Interactions (Monitor Closely)

  • SSRIs (e.g., fluoxetine): additive hyponatremia risk, require electrolyte monitoring.
  • ACE inhibitors: may enhance antidiuretic effect, monitor blood pressure and sodium levels.

Frequently Asked Questions

Nictur (desmopressin) is prescribed for central diabetes insipidus, nocturnal enuresis, hemophilia A to improve factor VIII levels, and von Willebrand disease to enhance von Willebrand factor release. These indications reflect its antidiuretic and hemostatic properties.

Desmopressin mimics the natural hormone vasopressin and binds to V2 receptors in the kidney collecting ducts. This triggers a cascade that increases cyclic AMP, causing aquaporin‑2 channels to move to the cell surface, which allows more water to be reabsorbed and concentrates the urine.

The appropriate dose of Nictur is individualized by the prescribing clinician based on the specific indication, patient age, weight, renal function and response to therapy. Dosage regimens are not standardized in public information and must follow the prescriber’s instructions.

The pregnancy and lactation categories for Nictur are not definitively established. Healthcare providers should weigh potential benefits against possible risks and discuss use with a qualified obstetrician or pediatrician before prescribing to pregnant or nursing individuals.

To request Nictur, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs) and required import documentation.

Nictur contains desmopressin, a selective V2‑receptor agonist, offering a longer half‑life and fewer vasoconstrictive effects than natural vasopressin. Compared with other antidiuretics, it provides more predictable water‑reabsorption and is the preferred choice for central diabetes insipidus and bleeding disorders due to its hemostatic activity.

Nictur should be stored at ambient temperature below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and avoid storing it in areas with high humidity or temperature fluctuations.

Nictur is taken orally. The tablet (or oral formulation) should be swallowed whole with water, unless the prescribing information advises otherwise. It is usually taken at the same times each day to maintain consistent plasma levels.

The most critical safety concerns are severe hyponatremia and water intoxication, which can lead to seizures, coma or death. Patients should be monitored for rapid weight gain, confusion, headache or nausea, and serum sodium should be checked regularly, especially during the initial treatment phase.

Nictur is contraindicated in individuals with known hypersensitivity to desmopressin, uncontrolled hyponatremia, severe renal impairment, or conditions predisposing to water retention such as congestive heart failure. Clinicians should also avoid use in patients taking interacting medications that markedly increase the risk of hyponatremia.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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