Product image of Nictur (Desmopressin Acetate) supplied by GNH India

Nictur

Active Ingredient:
Desmopressin Acetate
Origin:
EU

Nictur (Desmopressin Acetate)

Desmopressin, the active ingredient in Nictur, is a vasopressin analog presented as an oral tablet for oral use. It treats central diabetes insipidus, nocturnal enuresis, and bleeding disorders such as hemophilia A and von Willebrand disease in appropriate patients.

GNH India supplies Nictur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Gp-Pharm S.A.

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Indications & Clinical Uses

Desmopressin is a vasopressin analog used to manage disorders of water balance and certain bleeding disorders.

  • Central diabetes insipidus: reduces excessive urine output by concentrating urine.
  • Nocturnal enuresis: decreases nighttime bedwetting episodes.
  • Hemophilia A: raises plasma factor VIII levels to improve clotting.
  • von Willebrand disease: increases von Willebrand factor and enhances platelet adhesion.

How It Works

  • Desmopressin is a synthetic analogue of vasopressin that selectively activates V2 receptors on the renal collecting duct cells. Stimulation of these receptors triggers insertion of aquaporin‑2 water channels into the apical membrane, enhancing water reabsorption and producing concentrated urine. In the vascular endothelium, V2 activation promotes release of von Willebrand factor and factor VIII, improving haemostatic function.

Side Effects

Desmopressin may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Nausea: occasional, often transient.
  • Hyponatremia: mild reduction in serum sodium.
  • Facial flushing: brief redness of the skin.
  • Abdominal cramps: mild gastrointestinal discomfort.
  • Nasal congestion: when administered intranasally.

Serious or Rare Side Effects

  • Severe hyponatremia with seizures: potentially life‑threatening electrolyte disturbance.
  • Water intoxication: excessive fluid retention leading to edema.
  • Allergic reactions: rash, itching, or anaphylaxis in rare cases.
  • Thrombotic events: rare clot formation in predisposed individuals.

Precautions & Warnings

Before prescribing or dispensing Nictur, consider the following safety measures.

  • Monitor serum sodium: check electrolytes regularly, especially in high‑risk patients.
  • Adjust dose in renal impairment: reduce dosage if kidney function is compromised.
  • Use caution in the elderly: increased susceptibility to hyponatremia.
  • Limit fluid intake: advise patients to avoid excessive water consumption.
  • Contraindicated in known hypersensitivity: do not use if allergic to desmopressin.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Desmopressin can interact with several medicines; awareness of the interaction level helps guide safe use.

Major Interactions (Avoid)

  • Carbamazepine: reduces desmopressin efficacy.
  • Diuretics (especially thiazides): increase risk of hyponatremia.
  • NSAIDs: may potentiate water retention and hyponatremia.

Moderate Interactions (Monitor Closely)

  • SSRIs and other antidepressants: heighten hyponatremia risk.
  • ACE inhibitors: may amplify antidiuretic effect.
  • Anticoagulants (e.g., warfarin): possible alteration of bleeding risk.

Frequently Asked Questions

Nictur, containing desmopressin acetate, is prescribed for central diabetes insipidus, nocturnal enuresis (bedwetting), hemophilia A, and von Willebrand disease. In each case the drug helps regulate water balance or enhances clotting factor release, addressing the underlying pathophysiology of these disorders.

Desmopressin mimics the natural hormone vasopressin and selectively activates V2 receptors in the kidney’s collecting ducts. This triggers insertion of aquaporin‑2 channels, allowing more water to be reabsorbed and urine to become concentrated. It also stimulates endothelial cells to release von Willebrand factor and factor VIII, improving haemostasis.

The exact dose of Nictur is determined by the prescribing clinician based on the patient’s age, weight, renal function, and the specific indication. Healthcare professionals tailor the regimen to achieve the desired therapeutic effect while minimizing the risk of adverse events.

Safety data for desmopressin in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider after a careful risk‑benefit assessment.

To request Nictur, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs) and the necessary import documentation.

Nictur (desmopressin) is a synthetic vasopressin analogue with high selectivity for V2 receptors, offering a longer half‑life and fewer vasoconstrictive effects than natural vasopressin. Compared with other antidiuretic drugs, it provides more predictable water‑reabsorption and is also effective in certain bleeding disorders, making it a versatile therapeutic option.

Nictur should be stored at ambient temperature, below 25 °C. Keep the tablets in their original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability throughout its shelf life.

Nictur is taken orally, usually as a tablet, with or without water as directed by the prescriber. The exact timing (e.g., before bedtime for nocturnal enuresis) and any fluid‑restriction instructions are individualized based on the indication and patient response.

The most serious risks include severe hyponatremia, which can lead to seizures or coma, and water intoxication causing cerebral edema. Patients should be monitored for rapid weight gain, confusion, headache, or nausea, and serum sodium levels should be checked regularly during therapy.

Nictur is contraindicated in individuals with known hypersensitivity to desmopressin or any of its excipients, and in patients with uncontrolled hyponatremia or severe renal impairment where water balance cannot be safely managed. Clinicians must evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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