Product image of Nidagyl (Metronidazole) supplied by GNH India

Nidagyl

Active Ingredient:
Metronidazole
Origin:
EU

Nidagyl (Metronidazole)

Metronidazole, the active ingredient in Nidagyl, is a nitroimidazole antibiotic presented as an oral tablet for oral administration. It is used to treat anaerobic bacterial infections and selected protozoal diseases in both adult and pediatric patients when prescribed by a healthcare professional.

GNH India supplies Nidagyl as a licensed, Good Distribution Practice‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies, and clinics worldwide through regulated channels and ensuring quality and traceability for each batch, and supporting local regulatory requirements.

Manufacturer / TM Owner

Delorbis Pharmaceuticals Limited

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Indications & Clinical Uses

Metronidazole is employed to treat infections caused by anaerobic bacteria and susceptible protozoa.

  • Bacterial vaginosis: restores normal vaginal flora by eliminating anaerobic bacteria.
  • Trichomoniasis: eradicates Trichomonas vaginalis, relieving symptoms and preventing transmission.
  • Amoebiasis: clears intestinal Entamoeba histolytica infection, reducing dysentery.
  • Giardiasis: eliminates Giardia lamblia, improving gastrointestinal function.
  • Anaerobic intra‑abdominal, pelvic, skin and soft‑tissue infections: provides bactericidal activity against mixed anaerobic flora.
  • Clostridioides difficile‑associated diarrhea (adjunct): reduces toxin‑producing bacterial load when used with standard therapy.

How It Works

  • Metronidazole enters susceptible anaerobic microorganisms and is reduced by intracellular electron transport proteins, converting its nitro group to reactive intermediates. These metabolites bind to DNA, causing strand breakage and inhibition of nucleic acid synthesis, ultimately leading to cell death of anaerobic bacteria and protozoa.

Side Effects

Metronidazole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Metallic taste: transient metallic sensation in the mouth.
  • Diarrhea: loose stools that may be watery.
  • Headache: mild to moderate head pain.

Serious or Rare Side Effects

  • Seizures: convulsive episodes, especially with high plasma levels.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.

Precautions & Warnings

When prescribing Metronidazole, consider the following precautions:

  • Pregnancy: consult a healthcare provider as safety data are limited.
  • Alcohol: avoid consumption due to risk of a disulfiram‑like reaction.
  • Renal impairment: dose may require adjustment in severe kidney disease.
  • Hepatic disease: use with caution in patients with liver dysfunction.
  • Drug interactions: review all concomitant medications for potential interactions.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Metronidazole can interact with several medicines; monitoring is essential.

Major Interactions (Avoid)

  • Alcohol: may cause severe flushing, tachycardia, and hypotension.
  • Warfarin: increased anticoagulant effect, raising bleeding risk.
  • Lithium: elevated lithium levels, potentially leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Phenytoin: reduced phenytoin concentrations, possibly decreasing seizure control.
  • Cimetidine: may increase metronidazole plasma levels.
  • Oral contraceptives: possible reduction in contraceptive efficacy.

Frequently Asked Questions

Nidagyl contains metronidazole and is indicated for the treatment of bacterial vaginosis, trichomoniasis, amoebiasis, giardiasis, intra‑abdominal and pelvic anaerobic infections, skin and soft‑tissue anaerobic infections, and as adjunct therapy for Clostridioides difficile‑associated diarrhea.

Metronidazole is taken up by anaerobic microorganisms where it is reduced to reactive nitro radicals. These radicals damage DNA and inhibit nucleic acid synthesis, leading to bacterial and protozoal cell death.

The dosage of Nidagyl is determined by the prescribing clinician based on the specific infection, patient age, weight, renal and hepatic function, and local treatment guidelines. Patients should follow the prescriber’s instructions exactly.

Safety data for metronidazole in pregnancy are limited, and the pregnancy category is listed as unknown. It should be used only if the potential benefit outweighs the risk, and breastfeeding mothers should consult their healthcare provider before use.

To order Nidagyl, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nidagyl (metronidazole) is the most widely used nitroimidazole, offering a broad spectrum against anaerobic bacteria and protozoa. Alternatives such as tinidazole have longer half‑lives, allowing once‑daily dosing, but metronidazole remains the standard due to extensive clinical experience and lower cost.

Store Nidagyl at room temperature, below 25 °C, in its original packaging. Keep the tablets away from moisture, heat and direct sunlight to maintain potency. Do not store in the bathroom or near a kitchen sink.

Nidagyl is supplied as oral tablets that should be swallowed whole with a full glass of water. It may be taken with or without food, but taking it with food can reduce gastrointestinal irritation.

Serious adverse reactions include seizures, peripheral neuropathy, severe allergic responses such as anaphylaxis, and rare cases of Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience neurological symptoms, rash, or signs of an allergic reaction.

Nidagyl should be avoided in individuals with a known hypersensitivity to metronidazole or other nitroimidazoles, in patients with severe hepatic impairment, and in early pregnancy unless the benefits outweigh the risks. Caution is also advised for patients with significant renal dysfunction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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