Product image of Nidazea (Metronidazole) supplied by GNH India

Nidazea

Active Ingredient:
Metronidazole
Origin:
EU

Nidazea (Metronidazole)

Metronidazole, the active ingredient in Nidazea, is a nitroimidazole antibiotic presented as a topical formulation for topical use. It is employed to manage certain skin conditions caused by bacteria or protozoa, particularly in adults.
GNH India supplies Nidazea as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Dr. August Wolff Gmbh & Co. Kg Arzneimittel

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Indications & Clinical Uses

Metronidazole is used in dermatology to treat infections and inflammatory skin disorders.

  • Rosacea: reduces inflammatory papules, pustules and persistent facial redness.
  • Acanthosis nigricans: improves hyperpigmented, velvety plaques on skin folds.
  • Acne vulgaris: decreases bacterial load and inflammation, leading to fewer lesions.
  • Dermatologic infections: treats bacterial or protozoal skin infections, promoting lesion resolution.

How It Works

  • Metronidazole enters anaerobic or microaerophilic cells and is reduced by intracellular redox proteins to reactive nitro radicals. These radicals interact with DNA, causing strand breakage and inhibiting nucleic acid synthesis, which ultimately leads to microbial cell death and reduction of inflammatory mediators in the skin.

Side Effects

Metronidazole may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Skin irritation: localized redness or burning at the application site.
  • Dryness: mild desquamation or flaking of treated skin.
  • Pruritus: transient itching sensations.
  • Contact dermatitis: allergic skin reaction in sensitive individuals.
  • Taste alteration: occasional metallic taste when applied near oral mucosa.

Serious or Rare Side Effects

  • Severe hypersensitivity: angioedema, swelling of face or throat.
  • Stevens‑Johnson syndrome: rare severe skin blistering.
  • Neurotoxicity: peripheral neuropathy or dizziness with extensive use.
  • Hematologic changes: unexplained anemia or leukopenia.
  • Hepatotoxicity: elevated liver enzymes in susceptible patients.

Precautions & Warnings

Before using Nidazea, consider the following safety measures.

  • Pregnancy: Category B3 – use only if potential benefit justifies potential risk to the fetus.
  • Breastfeeding: consult a healthcare professional; minimal systemic absorption is expected.
  • Skin integrity: avoid application on broken or severely inflamed skin.
  • Allergies: discontinue use if signs of allergic reaction develop.
  • Concomitant medications: inform prescriber of all topical or systemic drugs.
  • Store at ambient temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Metronidazole can interact with other agents, affecting efficacy or safety.

Major Interactions (Avoid)

  • Alcohol: may cause a disulfiram‑like reaction with flushing and nausea.
  • Warfarin: increased anticoagulant effect, raising bleeding risk.
  • Lithium: potential for increased lithium toxicity.

Moderate Interactions (Monitor Closely)

  • Cimetidine: may raise metronidazole plasma levels.
  • Phenytoin: possible reduction in metronidazole effectiveness.
  • Other topical antibiotics: assess for additive skin irritation.

Frequently Asked Questions

Nidazea is a topical formulation of metronidazole used primarily to treat rosacea, acne vulgaris, acanthosis nigricans, and other dermatologic infections caused by susceptible bacteria or protozoa. It helps reduce inflammation, lesions, and abnormal skin pigmentation associated with these conditions.

Metronidazole penetrates microbial cells in the skin and is reduced to reactive nitro radicals. These radicals damage microbial DNA and inhibit nucleic acid synthesis, leading to cell death. The drug also modulates inflammatory pathways, decreasing cytokine release and reducing skin redness.

The specific dosing regimen for Nidazea is determined by the prescribing healthcare professional based on the indication, severity of the condition, and patient factors. Patients should follow the prescriber's instructions and the product label for application frequency and duration.

Metronidazole is classified as pregnancy category B3, indicating that it should be used only if the potential benefit justifies any potential risk to the fetus. Limited systemic absorption from topical use makes it relatively safe, but pregnant or breastfeeding women should consult their healthcare provider before use.

To order Nidazea, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with other topical antibiotics such as clindamycin or erythromycin, metronidazole offers both antimicrobial and anti‑inflammatory actions, making it especially effective for rosacea. It has a lower risk of developing bacterial resistance and is generally well tolerated on the skin.

Nidazea should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture, direct sunlight, and excessive heat to maintain product stability.

Nidazea is applied topically to the affected skin area, typically once or twice daily as directed by a healthcare professional. The skin should be clean and dry before application, and the product should be spread in a thin layer and gently massaged until fully absorbed.

Serious risks, though rare, include severe allergic reactions such as angioedema, Stevens‑Johnson syndrome, and systemic neurotoxicity like peripheral neuropathy. Patients should seek immediate medical attention if they experience swelling of the face or throat, widespread skin blistering, or neurological symptoms.

Individuals with known hypersensitivity to metronidazole or any component of the formulation should avoid using Nidazea. It is also contraindicated on severely damaged or ulcerated skin, and caution is advised for pregnant women, breastfeeding mothers, and patients on interacting medications such as warfarin or alcohol.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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