Product image of Nidef (Nifedipine) supplied by GNH India

Nidef

Active Ingredient:
Nifedipine
Origin:
EU

Nidef (Nifedipine)

Nifedipine, the active ingredient in Nidef, is a calcium channel blocker presented as an oral tablet for oral use. It treats hypertension and chronic stable angina in adult patients.

GNH India supplies Nidef as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Morningside Healthcare Ltd

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Indications & Clinical Uses

  • Nifedipine acts on the cardiovascular system to lower blood pressure and relieve chest pain.
  • Hypertension: reduces systemic arterial pressure and improves long‑term blood pressure control.
  • Chronic stable angina: decreases frequency of angina attacks by improving myocardial oxygen supply.
  • Raynaud's phenomenon: alleviates peripheral vasospasm and reduces ischemic episodes.

How It Works

  • Nifedipine selectively blocks L‑type calcium channels in vascular smooth muscle, preventing calcium influx. This inhibition leads to relaxation of arterial smooth muscle, vasodilation, decreased peripheral vascular resistance, and ultimately lower blood pressure and reduced cardiac workload.

Side Effects

Nifedipine may cause several adverse reactions, ranging from mild to serious.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness of the skin.
  • Peripheral edema: swelling of the ankles or lower legs.
  • Dizziness: especially upon standing.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure.
  • Myocardial infarction: rare but possible in high‑risk patients.
  • Hepatic dysfunction: abnormal liver enzymes or hepatitis.

Precautions & Warnings

  • Before initiating therapy, consider patient‑specific factors and monitor for adverse events.
  • Monitor blood pressure: ensure adequate control and avoid excessive drops.
  • Avoid abrupt discontinuation: taper to prevent rebound hypertension.
  • Use caution in hepatic impairment: dose adjustments may be required.
  • Use caution in heart failure: monitor for fluid retention.
  • Avoid concomitant grapefruit juice: may increase nifedipine levels.
  • Store at room temperature: keep in the original container, protect from moisture.

Avoid Interactions

Nifedipine can interact with several medicines, altering its effectiveness or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): increase plasma concentrations.
  • Simvastatin: risk of increased statin levels and myopathy.
  • Diltiazem or verapamil: additive cardiovascular depression.

Moderate Interactions (Monitor Closely):\n- Beta‑blockers: may enhance antihypertensive effect.

  • Diuretics: monitor electrolytes and blood pressure.

Frequently Asked Questions

Nidef contains nifedipine and is prescribed to manage hypertension and chronic stable angina, helping to lower blood pressure and reduce chest pain episodes in adult patients.

Nifedipine blocks L‑type calcium channels in vascular smooth muscle, causing the vessels to relax and dilate. This vasodilation lowers peripheral resistance, reduces blood pressure, and improves blood flow to the heart.

The specific dose of Nidef is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and other factors. Patients should follow the prescriber’s instructions.

The safety of nifedipine in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and under medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Nidef (nifedipine) belongs to the calcium channel blocker class, which differs from ACE inhibitors, ARBs, or beta‑blockers in its mechanism of vasodilation. It is particularly effective for patients who need rapid blood pressure reduction or have angina, but choice of therapy depends on individual clinical profiles.

Nidef should be stored at room temperature, below 25 °C, in its original packaging. Keep it away from moisture and direct sunlight to maintain product stability.

Nidef is taken orally, usually with or without food, as directed by the prescriber. Swallow the tablet whole with a full glass of water and do not crush or chew unless specifically instructed.

Serious risks include severe hypotension, myocardial infarction, and rare cases of hepatic dysfunction or allergic reactions. Patients should seek immediate medical attention if they experience fainting, chest pain, or signs of liver injury.

Nidef is contraindicated in patients with known hypersensitivity to nifedipine or other dihydropyridine calcium channel blockers, and should be used with caution in individuals with severe aortic stenosis, unstable heart failure, or significant liver disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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