Product image of Nife-Par (Nifedipine) supplied by GNH India

Nife-Par

Active Ingredient:
Nifedipine
Origin:
EU

Nife-Par (Nifedipine)

Nifedipine, the active ingredient in Nife-Par, is a calcium channel blocker (dihydropyridine) presented as an oral tablet for oral use. It treats hypertension, chronic stable angina, and Raynaud's phenomenon in adult patients.

GNH India supplies Nife-Par as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratorio Reig Jofre, S.A.

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Indications & Clinical Uses

Nifedipine acts on the vascular smooth‑muscle calcium channels to lower blood pressure and relieve myocardial oxygen demand, making it useful in several cardiovascular conditions.

  • Hypertension: reduces peripheral vascular resistance to achieve blood‑pressure control.
  • Chronic stable angina: improves coronary blood flow and decreases frequency of anginal episodes.
  • Raynaud's phenomenon: alleviates vasospasm in peripheral arteries, reducing attacks.

How It Works

  • Nifedipine selectively inhibits L‑type calcium channels in vascular smooth muscle, preventing calcium influx that is required for contraction. This leads to relaxation of arterial smooth muscle, vasodilation, and a consequent fall in peripheral vascular resistance and myocardial oxygen demand, thereby lowering blood pressure and relieving angina.

Side Effects

Nifedipine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness of the skin.
  • Peripheral edema: swelling of ankles or feet.
  • Dizziness or light‑headedness, especially on standing.
  • Reflex tachycardia: increased heart rate.
  • Nausea or abdominal discomfort.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure.
  • Myocardial infarction: rare but possible in high‑risk patients.
  • Atrioventricular block: conduction abnormalities.
  • Hepatic dysfunction: elevated liver enzymes.
  • Severe allergic reactions: rash, itching, swelling.
  • Life‑threatening arrhythmias.

Precautions & Warnings

Before prescribing Nife-Par, clinicians should evaluate patient history and monitor for specific concerns.

  • Cardiovascular assessment: ensure patient is not in acute heart failure.
  • Concomitant vasodilators: avoid additive hypotensive effects.
  • Liver function: adjust if hepatic impairment is present.
  • Elderly patients: start with lower doses and monitor closely.
  • Grapefruit juice: advise avoidance as it may increase drug levels.
  • Store at ambient temperature: keep below 25 °C, retain in original container, protect from moisture and direct sunlight.

Avoid Interactions

Nifedipine can interact with several medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may cause toxic plasma concentrations.
  • Simultaneous use with other potent vasodilators: risk of severe hypotension.
  • Phenytoin or carbamazepine: may reduce nifedipine effectiveness.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask tachycardia, requiring heart‑rate monitoring.
  • Digoxin: increased serum levels possible; monitor renal function.
  • Diuretics: may enhance hypotensive effect; adjust fluid status as needed.

Frequently Asked Questions

Nife-Par, containing nifedipine, is prescribed for hypertension, chronic stable angina, and Raynaud's phenomenon. In each case the drug helps lower blood pressure, improve coronary blood flow, or reduce peripheral vasospasm, respectively, as part of a physician‑directed treatment plan.

Nifedipine blocks L‑type calcium channels in the smooth muscle of arteries. By preventing calcium entry, the muscle relaxes, causing vasodilation. This reduces peripheral vascular resistance, leading to a fall in systemic blood pressure and decreased cardiac workload.

The dosage of Nife-Par is individualized by the prescribing clinician based on the patient’s condition, response, and tolerance. Healthcare providers determine the appropriate strength, frequency, and duration, and patients should follow the prescription label exactly.

Safety data for nifedipine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding must discuss use with their healthcare professional.

To request Nife-Par, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nifedipine belongs to the dihydropyridine calcium‑channel blocker class, which primarily causes arterial vasodilation. Compared with ACE inhibitors or beta‑blockers, it may produce a quicker reduction in blood pressure but can be associated with reflex tachycardia and peripheral edema. Choice depends on patient profile and comorbidities.

Nife-Par should be stored at ambient temperature, below 25 °C. Keep the tablets in the original blister pack or container, protect them from moisture, heat, and direct sunlight, and ensure they are out of reach of children.

Nife-Par is taken orally, usually with a full glass of water. It may be taken with or without food, but consistency with meals can help reduce gastrointestinal discomfort. Patients should swallow the tablet whole and not crush or chew it unless directed by a healthcare professional.

Serious adverse events include severe hypotension, myocardial infarction, atrioventricular block, and life‑threatening arrhythmias. Patients should seek immediate medical attention if they experience fainting, chest pain, rapid or irregular heartbeat, or signs of an allergic reaction such as swelling or difficulty breathing.

Nife-Par should not be used by individuals with known hypersensitivity to nifedipine or any other dihydropyridine calcium‑channel blockers. Caution is also advised for patients with severe aortic stenosis, unstable angina, or recent myocardial infarction, and it is contraindicated in those taking strong CYP3A4 inhibitors without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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