Nifecard (Nifedipine)

Nifedipine acts on the cardiovascular system to manage disorders of blood pressure and coronary circulation.

• Hypertension: reduces systolic and diastolic pressure by relaxing arterial smooth muscle.
• Chronic stable angina: alleviates chest pain by improving myocardial oxygen supply.
• Raynaud's phenomenon: diminishes vasospasm in peripheral arteries, reducing episodes of color change and pain.

• Nifedipine selectively blocks L‑type calcium channels in vascular smooth muscle, preventing calcium influx that is necessary for contraction. This inhibition leads to arterial vasodilation, decreased peripheral vascular resistance, and ultimately lower blood pressure and reduced cardiac workload.

Nifedipine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

• Headache: mild to moderate pain often occurring shortly after dosing.
• Flushing: transient warmth and redness of the skin.
• Peripheral edema: swelling of the ankles or lower legs.
• Dizziness: sensation of light‑headedness, especially when standing quickly.

Serious or Rare Side Effects

• Severe hypotension: marked drop in blood pressure that can cause fainting.
• Myocardial infarction: rare occurrence of heart attack, particularly in patients with pre‑existing coronary disease.
• Atrioventricular block: abnormal heart rhythm requiring medical attention.

Before initiating therapy, clinicians should consider several safety measures.

• Blood pressure monitoring: check regularly to avoid excessive hypotension.
• Discontinuation caution: do not stop abruptly; taper under medical supervision.
• Hepatic impairment: adjust dose if liver function is compromised.
• Heart failure: use with caution, monitoring for worsening symptoms.
• Drug interactions: review concomitant medications for additive blood‑pressure effects.
• Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Nifedipine can interact with several drug classes, influencing its efficacy and safety.

Major Interactions (Avoid)

• Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase nifedipine plasma levels.
• Grapefruit juice: can markedly raise drug concentration, raising risk of hypotension.
• Other potent antihypertensives (e.g., ACE inhibitors, ARBs): may cause additive blood‑pressure lowering.

Moderate Interactions (Monitor Closely):\n- Beta‑blockers: combined effect on heart rate and blood pressure requires monitoring.

• Diuretics: may enhance orthostatic hypotension; adjust fluid status as needed.