Product image of Nifedipin Retard Terapia (Nifedipine) supplied by GNH India

Nifedipin Retard Terapia

Active Ingredient:
Nifedipine
Origin:
EU

Nifedipin Retard Terapia (Nifedipine)

Nifedipine, the active ingredient in Nifedipin Retard Terapia, is a calcium channel blocker presented as an extended‑release oral tablet for oral use. It treats hypertension, chronic stable angina, and Raynaud's phenomenon in adult patients.

GNH India supplies Nifedipin Retard Terapia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Terapia S.A.

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Indications & Clinical Uses

  • Nifedipine is used to manage conditions related to vascular tone and myocardial oxygen demand.
  • Hypertension: lowers systemic blood pressure by arterial vasodilation.
  • Chronic stable angina: reduces frequency of angina attacks by improving coronary blood flow.
  • Raynaud's phenomenon: alleviates peripheral vasospasm and diminishes attack severity.

How It Works

  • Nifedipine selectively blocks L‑type calcium channels in vascular smooth muscle and cardiac myocytes, preventing calcium influx during depolarization. This inhibition causes relaxation of arterial smooth muscle, producing vasodilation, reduced peripheral resistance, and lower myocardial oxygen consumption. The extended‑release formulation delivers a gradual onset and sustained plasma concentration, supporting stable blood pressure control and anti‑anginal effect.

Side Effects

Nifedipine may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dizziness: sensation of light‑headedness, especially after standing.
  • Headache: mild to moderate intensity, often transient.
  • Flushing: warm sensation and reddening of the skin.
  • Peripheral edema: swelling of ankles or lower legs.

Serious or Rare Side Effects

  • Severe hypotension: markedly low blood pressure requiring medical attention.
  • Myocardial infarction: rare occurrence of heart attack.
  • Hepatic dysfunction: abnormal liver enzyme elevations or hepatitis.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Blood pressure monitoring: check regularly to avoid excessive hypotension.
  • Abrupt discontinuation: taper dose to prevent rebound hypertension.
  • Hepatic impairment: use with caution; dose adjustment may be needed.
  • Heart failure: monitor for worsening symptoms.
  • Grapefruit juice: avoid as it can increase plasma levels.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Nifedipine can interact with several medicines, affecting safety or efficacy.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may raise nifedipine concentrations.
  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil): risk of severe hypotension.
  • Concurrent antihypertensives (e.g., ACE inhibitors, beta‑blockers): may cause excessive blood pressure drop.

Moderate Interactions (Monitor Closely):\n- CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce therapeutic effect.

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): can blunt antihypertensive response.

Frequently Asked Questions

Nifedipin Retard Terapia contains nifedipine, which is prescribed to manage hypertension, chronic stable angina, and Raynaud's phenomenon. It works by relaxing blood vessels, lowering blood pressure, and improving blood flow to the heart and peripheral tissues.

Nifedipine blocks L‑type calcium channels on vascular smooth muscle and cardiac cells, preventing calcium entry that triggers contraction. This leads to arterial relaxation, reduced peripheral resistance, lower blood pressure, and decreased myocardial oxygen demand, helping to control angina and improve peripheral circulation.

The specific dose and dosing schedule of Nifedipin Retard Terapia are determined by the prescribing clinician based on the patient’s condition, response, and other individual factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for nifedipine in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nifedipine belongs to the calcium channel blocker class, offering a distinct mechanism of arterial vasodilation compared with ACE inhibitors, beta‑blockers or diuretics. Its extended‑release formulation provides steady plasma levels, which can be advantageous for patients needing consistent blood pressure control and angina relief.

Store the tablets at room temperature, below 25 °C, in the original packaging. Keep them away from moisture, direct sunlight and heat sources to maintain stability and potency throughout the shelf life.

The medication is taken orally as an extended‑release tablet. It should be swallowed whole with a glass of water, preferably at the same time each day, and not crushed, chewed, or split, to preserve the controlled‑release properties.

Serious adverse events, though rare, include severe hypotension, myocardial infarction, and liver dysfunction. Patients should seek immediate medical attention if they experience sudden dizziness, chest pain, or signs of liver injury such as jaundice or dark urine.

Individuals with known hypersensitivity to nifedipine or any component of the formulation should avoid the product. Caution is also advised for patients with severe aortic stenosis, unstable heart failure, or those taking contraindicated medications; a healthcare professional must evaluate suitability.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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