Product image of Nifedipin T Retard Al (Nifedipine) supplied by GNH India

Nifedipin T Retard Al

Active Ingredient:
Nifedipine
Origin:
EU

Nifedipin T Retard Al (Nifedipine)

Nifedipine, the active ingredient in Nifedipin T Retard Al, is a calcium channel blocker presented as an oral tablet for oral use. It is employed to lower high blood pressure and to relieve chest pain caused by reduced blood flow to the heart in adult patients.

GNH India supplies Nifedipin T Retard Al as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aliud Pharma Gmbh

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Indications & Clinical Uses

Nifedipine acts on the vascular smooth‑muscle calcium channels to manage cardiovascular conditions.

  • Hypertension: lowers systemic blood pressure by relaxing arterial smooth muscle.
  • Chronic stable angina: reduces myocardial oxygen demand and improves exercise tolerance.
  • Coronary artery disease: helps prevent ischemic episodes by enhancing coronary blood flow.

How It Works

  • Nifedipine selectively blocks L‑type calcium channels in vascular smooth muscle, preventing calcium influx that is necessary for contraction. This inhibition leads to vasodilation of peripheral arteries, decreasing systemic vascular resistance and lowering arterial pressure. In the coronary circulation, the resulting vasodilation improves myocardial oxygen delivery while reducing cardiac afterload, thereby alleviating angina symptoms.

Side Effects

Nifedipine may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Headache: mild to moderate pressure sensation.
  • Flushing: transient warmth and redness of the skin.
  • Peripheral edema: swelling of ankles or feet.
  • Dizziness or light‑headedness, especially on standing.
  • Tachycardia: increased heart rate.
  • Nausea or abdominal discomfort.

Serious or Rare Side Effects

  • Severe hypotension leading to fainting.
  • Myocardial infarction or worsening angina.
  • Life‑threatening arrhythmias.
  • Hepatic dysfunction or jaundice.
  • Severe allergic reactions such as Stevens‑Johnson syndrome.

Precautions & Warnings

Before initiating therapy with nifedipine, consider the following safety measures.

  • Blood pressure monitoring: regularly check to avoid excessive hypotension.
  • Cardiac assessment: evaluate for recent myocardial infarction or unstable angina.
  • Hepatic function: use cautiously in patients with liver impairment.
  • Concomitant antihypertensives: adjust doses to prevent additive blood‑pressure lowering.
  • Discontinuation: avoid abrupt cessation to reduce rebound hypertension risk.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nifedipine can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may cause toxic levels of nifedipine.
  • Grapefruit juice: significantly increases plasma concentration.
  • Concurrent use with other potent vasodilators: risk of severe hypotension.

Moderate Interactions (Monitor Closely):\n- Beta‑blockers: additive effect on heart rate and blood pressure.

  • Digoxin: may increase digoxin serum levels.
  • Diuretics: potential electrolyte disturbances and enhanced hypotensive response.

Frequently Asked Questions

Nifedipin T Retard Al contains nifedipine, which is prescribed to manage high blood pressure (hypertension) and to treat chronic stable angina caused by reduced coronary blood flow. It may also be used in patients with coronary artery disease to improve myocardial oxygen delivery.

Nifedipine blocks L‑type calcium channels on vascular smooth‑muscle cells, preventing calcium entry that triggers contraction. This causes arterial dilation, lowers peripheral resistance, and reduces blood pressure. In the heart’s vessels, the dilation improves blood flow, decreasing the workload and oxygen demand of the myocardium.

The specific dose and dosing schedule for Nifedipin T Retard Al are determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and other individual factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for nifedipine in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks and alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Nifedipine belongs to the dihydropyridine calcium‑channel blocker class, which primarily causes arterial vasodilation. Compared with ACE inhibitors or beta‑blockers, it has a rapid onset of vasodilatory effect but may cause reflex tachycardia and peripheral edema more frequently. Choice of therapy depends on patient profile and comorbidities.

Store Nifedipin T Retard Al at room temperature, below 25 °C, in the original packaging. Keep the product away from moisture, direct sunlight, and excessive heat to maintain its stability and potency.

Nifedipin T Retard Al is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed, unless the prescribing information specifically allows a different method of administration.

Serious risks include severe hypotension, myocardial infarction, life‑threatening arrhythmias, and rare allergic reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience fainting, chest pain, irregular heartbeat, or signs of a severe skin reaction.

Patients with known hypersensitivity to nifedipine or other dihydropyridine calcium‑channel blockers should not use the product. It is also contraindicated in individuals with severe aortic stenosis, uncontrolled heart failure, or those taking strong CYP3A4 inhibitors without close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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