Product image of Nifedipina Doc (Nifedipine) supplied by GNH India

Nifedipina Doc

Active Ingredient:
Nifedipine
Origin:
EU

Nifedipina Doc (Nifedipine)

Nifedipine, the active ingredient in Nifedipina Doc, is a calcium channel blocker presented as an oral tablet for oral use. It treats hypertension, angina pectoris and Raynaud's phenomenon in adult patients.

GNH India supplies Nifedipina Doc as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product conforms to EU regulatory standards and is manufactured under GMP conditions. Our distribution network ensures timely delivery to healthcare facilities across multiple continents, including Europe, Asia, Africa and the Americas. The offering includes comprehensive regulatory documentation for import and compliance.

Manufacturer / TM Owner

Doc Generici S.R.L.

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Indications & Clinical Uses

  • Nifedipine is used to manage conditions related to cardiovascular tone and peripheral blood flow.
  • Hypertension: reduces systemic blood pressure by causing arterial vasodilation.
  • Angina pectoris: alleviates chest pain by improving coronary blood flow.
  • Raynaud's phenomenon: diminishes vasospastic attacks in the extremities.

How It Works

  • Nifedipine selectively blocks L‑type calcium channels in vascular smooth‑muscle cells, preventing calcium entry that drives contraction. This inhibition relaxes arterial smooth muscle, producing vasodilation, lowering peripheral resistance, and decreasing arterial pressure. In coronary vessels the same effect enhances myocardial oxygen delivery, while in peripheral arteries it mitigates vasospasm associated with Raynaud's phenomenon.

Side Effects

Nifedipine may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Headache: mild to moderate pain often occurring shortly after dosing.
  • Flushing: transient warmth and redness of the skin, especially on the face.
  • Peripheral edema: swelling of the ankles or lower legs due to fluid accumulation.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure that can cause dizziness or fainting.
  • Myocardial infarction: rare occurrence of heart attack, particularly in patients with pre‑existing coronary disease.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis requiring immediate medical attention.

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several safety measures.
  • Blood pressure monitoring: check baseline and periodic readings to avoid excessive hypotension.
  • Cardiovascular status: avoid rapid dose escalation in patients with severe aortic stenosis or cardiogenic shock.
  • Liver function: assess hepatic impairment, as metabolism may be reduced.
  • Concomitant medications: review for CYP3A4 inhibitors or inducers that could alter drug levels.
  • Pregnancy and lactation: use only if the potential benefit justifies the unknown risk to the fetus or infant.
  • Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and light.

Avoid Interactions

Nifedipine can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may raise plasma concentrations and increase toxicity risk.
  • Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): can lower effectiveness by accelerating metabolism.
  • Grapefruit juice: markedly elevates drug levels, potentially leading to severe hypotension.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: combined use may cause excessive lowering of blood pressure or heart rate.
  • Diuretics: additive antihypertensive effect; monitor electrolytes and renal function.

Frequently Asked Questions

Nifedipina Doc contains the active ingredient nifedipine and is indicated for the treatment of hypertension, angina pectoris, and Raynaud's phenomenon. These conditions involve elevated blood pressure, chest pain due to reduced coronary blood flow, and episodic vasospasm of peripheral arteries, respectively. The medication helps control blood pressure, relieve chest discomfort, and reduce the frequency of vasospastic attacks.

Nifedipine belongs to the dihydropyridine class of calcium‑channel blockers. It selectively inhibits L‑type calcium channels in vascular smooth‑muscle cells, preventing calcium influx that is required for muscle contraction. This results in relaxation of arterial smooth muscle, vasodilation, reduced peripheral resistance, and lower arterial pressure. In coronary arteries, the same mechanism improves myocardial oxygen supply.

The appropriate dose of Nifedipina Doc is determined by the prescribing healthcare professional based on the individual patient's condition, response, and tolerability. Typical starting doses for hypertension or angina are established in clinical guidelines, but the exact regimen, including strength and frequency, must be set by the prescriber and adjusted as needed.

Safety data for nifedipine in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks and alternatives with their physician.

To place an order, visit the product page on gnhindia.com and submit an enquiry specifying the required quantity of Nifedipina Doc. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details (including any cold‑chain requirements) and assists with import documentation.

Nifedipina Doc, as a calcium‑channel blocker, primarily causes vasodilation, whereas beta‑blockers reduce cardiac output and ACE inhibitors block angiotensin‑II formation. Compared with other dihydropyridine agents, nifedipine has a rapid onset and is effective for both hypertension and angina. Choice of therapy depends on patient comorbidities, tolerability, and physician preference.

Store Nifedipina Doc at ambient temperature, preferably below 25 °C (77 °F). Keep the tablets in the original packaging, protect them from moisture, heat, and direct sunlight. Do not store in bathrooms or near kitchen appliances. Ensure the container is tightly closed to maintain product stability.

Nifedipina Doc is taken orally as a tablet. Swallow the tablet whole with a full glass of water; it may be taken with or without food. Do not crush, chew, or split the tablet unless specifically instructed by a healthcare professional. Follow the dosing schedule prescribed by the physician.

The most serious adverse events include severe hypotension, which can cause dizziness or fainting; myocardial infarction, particularly in patients with existing coronary artery disease; and allergic reactions such as rash, swelling, or anaphylaxis. Patients should seek immediate medical attention if they experience sudden weakness, chest pain, or signs of a severe allergic response.

Nifedipina Doc is contraindicated in individuals with known hypersensitivity to nifedipine or any excipients, as well as patients with severe aortic stenosis, cardiogenic shock, or uncontrolled heart failure. Caution is also advised for those taking potent CYP3A4 inhibitors or inducers without appropriate dose adjustments. Always consult a healthcare professional before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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