Product image of Nifedipina Doc Generici (Nifedipine) supplied by GNH India

Nifedipina Doc Generici

Active Ingredient:
Nifedipine
Origin:
EU

Nifedipina Doc Generici (Nifedipine)

Nifedipine, the active ingredient in Nifedipina Doc Generici, is a calcium channel blocker presented as an oral dosage form for oral use. It is employed to lower high blood pressure, relieve chest pain from angina, and improve blood flow in Raynaud's phenomenon, primarily in adult patients.
GNH India supplies Nifedipina Doc Generici as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Doc Generici S.R.L.

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Indications & Clinical Uses

  • Nifedipine belongs to the calcium channel blocker class and is indicated for several cardiovascular conditions.
  • Hypertension: lowers systemic blood pressure by relaxing arterial smooth muscle.
  • Angina pectoris: reduces myocardial oxygen demand through coronary vasodilation.
  • Raynaud's phenomenon: improves peripheral blood flow by preventing vasospasm.

How It Works

  • Nifedipine selectively blocks L‑type calcium channels in vascular smooth muscle, preventing calcium influx that is required for contraction. This inhibition leads to relaxation of arterial smooth muscle, resulting in vasodilation, decreased peripheral vascular resistance, and ultimately lower blood pressure and improved myocardial oxygen delivery.

Side Effects

Nifedipine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: warm sensation, often transient.
  • Peripheral edema: swelling of ankles or feet.
  • Dizziness or light‑headedness.
  • Tachycardia: increased heart rate.
  • Nausea or abdominal discomfort.

Serious or Rare Side Effects

  • Severe hypotension: sudden, marked drop in blood pressure.
  • Myocardial infarction: rare but possible in high‑risk patients.
  • Atrial fibrillation or other arrhythmias.
  • Hepatic dysfunction: elevated liver enzymes.
  • Severe allergic reactions: rash, swelling, anaphylaxis.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

  • Before initiating therapy, consider the following safety measures.
  • Blood pressure monitoring: ensure baseline and periodic checks.
  • Cardiovascular disease: evaluate for heart failure or recent myocardial infarction.
  • Liver impairment: dose adjustment may be required.
  • Elderly patients: start with lower doses due to altered pharmacokinetics.
  • Drug interactions: review concomitant medications for CYP3A4 substrates or inhibitors.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nifedipine can interact with several drug classes; some require avoidance while others need close monitoring.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may raise nifedipine levels.
  • Co‑administration with other antihypertensives: risk of additive hypotension.
  • Grapefruit juice: enhances oral absorption, increasing exposure.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce efficacy.
  • Beta‑blockers: may mask tachycardia, requiring heart‑rate monitoring.
  • Diuretics: can amplify electrolyte disturbances and volume depletion.

Frequently Asked Questions

Nifedipina Doc Generici is a generic formulation of nifedipine, a calcium channel blocker used to manage high blood pressure, relieve chest pain caused by angina pectoris, and improve blood flow in patients with Raynaud's phenomenon. It works by relaxing blood vessels, which helps lower vascular resistance and improve circulation.

Nifedipine blocks L‑type calcium channels in the smooth muscle of arteries. By preventing calcium entry, it inhibits muscle contraction, leading to vasodilation. This reduces peripheral resistance, lowers blood pressure, and increases coronary blood flow, which alleviates angina and improves peripheral circulation in Raynaud's phenomenon.

The appropriate dose of Nifedipina Doc Generici is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and other medications. Dosage adjustments may be needed for elderly patients or those with liver impairment. Always follow the prescriber’s instructions.

Safety data for nifedipine in pregnancy and lactation are limited, and the product is classified as pregnancy category unknown. It should only be used if the potential benefit justifies the potential risk to the fetus. Breastfeeding mothers should consult their healthcare provider before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details, and any required import documentation.

Nifedipine is a dihydropyridine calcium channel blocker, primarily causing arterial vasodilation. Compared with amlodipine, another dihydropyridine, nifedipine has a shorter half‑life and may require more frequent dosing. Both lower blood pressure, but nifedipine can produce more pronounced reflex tachycardia, whereas amlodipine tends to have a smoother blood‑pressure profile.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original packaging to protect it from moisture and light. Do not store in humid or excessively hot environments, and keep out of reach of children.

Nifedipina Doc Generici is taken orally, usually with a full glass of water. It can be taken with or without food, but consistent administration with respect to meals helps maintain stable blood levels. Swallow tablets whole; do not crush or chew unless specifically instructed by a healthcare professional.

The most serious risks include severe hypotension, which can cause dizziness, fainting, or shock; myocardial infarction, especially in patients with existing coronary artery disease; and rare but life‑threatening skin reactions such as Stevens‑Johnson syndrome. Prompt medical attention is required if any of these symptoms occur.

Nifedipina Doc Generici should be avoided in patients with known hypersensitivity to nifedipine or any excipients, those experiencing severe hypotension or cardiogenic shock, and individuals with a recent myocardial infarction unless specifically directed by a cardiologist. Caution is also advised for patients with severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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