Product image of Nifedipina Generis (Nifedipine) supplied by GNH India

Nifedipina Generis

Active Ingredient:
Nifedipine
Origin:
EU

Nifedipina Generis (Nifedipine)

Nifedipine, the active ingredient in Nifedipina Generis, is a calcium channel blocker presented as an oral tablet for oral use. It is employed to manage high blood pressure, chest pain from angina, and peripheral vascular disorders such as Raynaud's phenomenon.

GNH India supplies Nifedipina Generis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company follows EU manufacturing standards and provides full regulatory documentation for global distribution.

Manufacturer / TM Owner

Generis Farmacêutica, S.A.

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Indications & Clinical Uses

  • Nifedipine acts on the cardiovascular system to lower vascular resistance, making it useful for several related conditions.
  • Hypertension: reduces systolic and diastolic blood pressure by causing arterial vasodilation.
  • Angina pectoris: relieves chest pain by improving coronary blood flow.
  • Raynaud's phenomenon: diminishes frequency and severity of vasospastic attacks in the extremities.

How It Works

  • Nifedipine selectively blocks L‑type calcium channels in vascular smooth‑muscle cells, preventing calcium influx that drives contraction. This inhibition leads to relaxation of arterial smooth muscle, a fall in peripheral vascular resistance, and a reduction in arterial pressure. In coronary arteries, the vasodilatory effect enhances myocardial oxygen delivery, helping to alleviate ischemic chest pain.

Side Effects

Nifedipine may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Headache
  • Flushing
  • Peripheral edema
  • Dizziness

Serious or Rare Side Effects

  • Severe hypotension
  • Cardiac arrhythmia
  • Hepatotoxicity (rare)

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several safety measures.
  • Monitor blood pressure: check regularly after dose initiation.
  • Assess cardiac function: avoid in patients with severe aortic stenosis.
  • Review concomitant medications: consider interactions with CYP3A4 inhibitors.
  • Use caution in hepatic impairment: dose may need adjustment.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Nifedipine can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole) may increase plasma concentrations.
  • Grapefruit juice can markedly raise nifedipine levels.
  • Concurrent use with other potent vasodilators (e.g., nitroglycerin) may cause severe hypotension.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask tachycardia.
  • Diuretics: additive blood‑pressure‑lowering effect.
  • Digoxin: potential increase in serum digoxin concentrations.

Frequently Asked Questions

Nifedipina Generis contains nifedipine, a calcium‑channel‑blocking agent prescribed to lower high blood pressure, relieve angina pectoris, and treat Raynaud's phenomenon by improving blood flow to the extremities.

Nifedipine blocks L‑type calcium channels in vascular smooth‑muscle, preventing calcium entry that triggers contraction. This causes arterial relaxation, reduces peripheral resistance, lowers blood pressure, and enhances coronary blood flow, which helps relieve chest pain.

The exact dose is individualized. A qualified prescriber determines the appropriate strength, frequency and duration based on the patient’s condition, response to therapy and any co‑existing medical issues.

Safety data are limited. Nifedipine should be used during pregnancy or lactation only if the potential benefit justifies any possible risk to the fetus or infant, and under close medical supervision.

Enquiries are submitted via the product page at gnhindia.com, where you specify the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nifedipine belongs to the dihydropyridine calcium‑channel blocker class, offering potent arterial vasodilation. Compared with beta‑blockers, it does not reduce heart rate, and unlike ACE inhibitors, it does not affect the renin‑angiotensin system. It is often chosen when a rapid blood‑pressure‑lowering effect is desired or when patients cannot tolerate other classes.

Store the tablets at ambient temperature below 25 °C, in the original blister pack or container, protected from moisture, heat and direct light. Keep out of reach of children and do not use after the expiry date printed on the packaging.

The product is taken orally. Swallow the tablet whole with a full glass of water, preferably at the same time each day. Do not crush, chew or split the tablet unless specifically instructed by a healthcare professional.

Serious adverse events include severe hypotension, which can cause dizziness or fainting, cardiac arrhythmias, and rare cases of liver injury. Patients should seek immediate medical attention if they experience sudden weakness, chest pain, irregular heartbeat or signs of liver dysfunction such as jaundice.

Contraindications include known hypersensitivity to nifedipine or any excipients, severe aortic stenosis, uncontrolled heart failure, and cardiogenic shock. Caution is also advised in patients with significant hepatic impairment or those taking interacting medications that could raise nifedipine levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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