Product image of Nifedipine Relonchem (Nifedipine) supplied by GNH India

Nifedipine Relonchem

Active Ingredient:
Nifedipine
Origin:
EU

Nifedipine Relonchem (Nifedipine)

Nifedipine, the active ingredient in Nifedipine Relonchem, is a calcium channel blocker presented as an oral tablet for oral use. It belongs to the dihydropyridine subclass and is used to treat hypertension, chronic stable angina, and Raynaud's phenomenon in adult patients by relaxing vascular smooth muscle and improving coronary blood flow.

GNH India supplies Nifedipine Relonchem as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies, and clinics worldwide and ensuring regulatory compliance in each market.

Manufacturer / TM Owner

Relon Chem Limited

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Indications & Clinical Uses

  • Nifedipine is a calcium channel blocker indicated for several cardiovascular and peripheral vascular conditions.
  • Hypertension: reduces elevated blood pressure by inducing peripheral vasodilation.
  • Chronic stable angina: alleviates chest pain by improving coronary blood flow.
  • Raynaud's phenomenon: diminishes frequency and severity of vasospastic attacks in peripheral arteries.

How It Works

  • Nifedipine selectively inhibits L‑type calcium channels in vascular smooth muscle and cardiac myocytes. By blocking calcium influx, it prevents contraction of arterial smooth muscle, causing dose‑dependent vasodilation of peripheral arteries and coronary vessels. The resulting decrease in systemic vascular resistance lowers arterial pressure, while enhanced coronary blood flow reduces myocardial oxygen demand, providing anti‑anginal benefit. The drug’s effect is more pronounced in arterioles than in veins, contributing to its efficacy in treating hypertension and peripheral vasospasm.

Side Effects

Nifedipine may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Headache: mild to moderate headache often occurring at treatment initiation.
  • Flushing: transient facial or upper body warmth and redness.
  • Peripheral edema: swelling of ankles or lower legs due to fluid accumulation.
  • Dizziness: light‑headedness, especially when standing quickly.
  • Nausea: mild gastrointestinal upset.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure leading to fainting.
  • Myocardial infarction: rare occurrence of heart attack, particularly in patients with pre‑existing coronary disease.
  • Atrioventricular block: conduction disturbances requiring medical attention.
  • Hepatotoxicity: abnormal liver function tests indicating possible liver injury.
  • Allergic reactions: rash, pruritus, or anaphylaxis in susceptible individuals.

Precautions & Warnings

Before prescribing Nifedipine, clinicians should consider several precautionary measures to ensure safe use.

  • Cardiovascular assessment: evaluate for severe aortic stenosis or heart failure before initiation.
  • Concomitant nitrates: avoid co‑administration as it may cause profound hypotension.
  • Liver impairment: use lower doses and monitor hepatic function in patients with hepatic disease.
  • Elderly patients: start with the lowest effective dose and monitor for orthostatic hypotension.
  • Pregnancy and lactation: avoid use unless benefits outweigh potential risks, as safety data are limited.
  • Store at ambient temperature: keep tablets below 25 °C in the original container, protected from moisture and light.

Avoid Interactions

Nifedipine can interact with other medicines, altering its effectiveness or increasing adverse effects.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may raise nifedipine plasma levels, risking toxicity.
  • Grapefruit juice: can significantly increase drug concentration, leading to severe hypotension.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce efficacy by lowering plasma concentrations.
  • Beta‑blockers: combined use may enhance antihypertensive effect, requiring blood pressure monitoring.
  • Diuretics: may potentiate orthostatic hypotension; adjust dosing as needed.

Frequently Asked Questions

Nifedipine Relonchem contains the active ingredient nifedipine, a calcium‑channel‑blocking agent that is prescribed to lower high blood pressure, relieve chest pain caused by chronic stable angina, and reduce the frequency of vasospastic attacks in Raynaud's phenomenon. It is intended for adult patients and is supplied as an oral tablet that must be prescribed by a qualified health‑care professional.

Nifedipine selectively blocks L‑type calcium channels in vascular smooth muscle and cardiac myocytes. By preventing calcium entry, the drug relaxes arterial smooth muscle, producing dose‑dependent vasodilation, lowering systemic vascular resistance, and improving coronary blood flow. This mechanism reduces arterial pressure and myocardial oxygen demand, providing antihypertensive and anti‑anginal effects.

The appropriate dose of Nifedipine Relonchem is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and any concomitant medications. Dosage may be adjusted during treatment to achieve target blood pressure or symptom control, and patients should follow the specific instructions provided on the prescription label.

Safety data for nifedipine in pregnancy are limited, and the drug is classified as a category where benefits must outweigh potential risks. It is generally avoided unless clearly needed. Nifedipine is excreted in breast milk, so nursing mothers should consult their health‑care provider before using the medication to assess risk to the infant.

To place an order, visit the product page on gnhindia.com and submit an enquiry with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifying trade or institutional credentials before providing a formal quotation, confirming availability, shipping terms (including any temperature‑controlled logistics), and necessary import documentation.

Compared with beta‑blockers or ACE inhibitors, nifedipine primarily induces vasodilation through calcium‑channel blockade, leading to rapid blood pressure reduction. It is especially useful in patients with peripheral vascular disease or angina, whereas beta‑blockers reduce heart rate and ACE inhibitors affect the renin‑angiotensin system. Choice of therapy depends on comorbidities, tolerability, and physician judgment.

Nifedipine Relonchem tablets should be stored at ambient temperature, preferably below 25 °C, in the original container to protect them from moisture, light, and excessive heat. Keeping the product in a dry place helps maintain potency throughout its shelf life. Do not refrigerate or freeze the tablets unless specifically instructed by the supplier.

The medication is taken orally, usually with a glass of water. Depending on the prescribed regimen, tablets may be taken once daily or in divided doses, and some formulations are designed for extended release. Patients should follow the dosing schedule indicated on the prescription label and avoid crushing or chewing extended‑release tablets unless directed by a health‑care professional.

Serious adverse events, though uncommon, include severe hypotension, myocardial infarction, atrioventricular block, hepatotoxicity, and life‑threatening allergic reactions such as anaphylaxis. Patients experiencing fainting, chest pain, irregular heartbeats, jaundice, or widespread rash should seek immediate medical attention. Regular monitoring and adherence to prescribed doses help mitigate these risks.

Nifedipine is contraindicated in patients with known hypersensitivity to the drug or any of its excipients, those with severe aortic stenosis, and individuals experiencing cardiogenic shock. Caution is also advised for patients with significant hepatic impairment or uncontrolled heart failure. Clinicians must review the patient’s medical history before initiating therapy to ensure safety.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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