Product image of Nifelat La (Nifedipine) supplied by GNH India

Nifelat La

Active Ingredient:
Nifedipine
Origin:
EU

Nifelat La (Nifedipine)

Nifedipine, the active ingredient in Nifelat La, is a calcium channel blocker presented as an oral tablet for oral use. It is employed to manage high blood pressure, chest pain due to angina, and peripheral vascular disorders such as Raynaud's phenomenon.

GNH India supplies Nifelat La as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory‑approved batches to qualified healthcare institutions.

Manufacturer / TM Owner

Remedica Ltd

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Indications & Clinical Uses

  • Nifedipine is used to treat conditions that involve vascular smooth‑muscle constriction and elevated blood pressure.
  • Hypertension: lowers systemic blood pressure by dilating peripheral arteries.
  • Angina pectoris: reduces myocardial oxygen demand by decreasing afterload.
  • Raynaud's phenomenon: improves blood flow to extremities by relaxing digital arteries.

How It Works

  • Nifedipine selectively blocks L‑type calcium channels in vascular smooth muscle and cardiac myocytes. Inhibition of calcium influx prevents contraction, leading to vasodilation of arterial beds, reduced peripheral resistance, and decreased cardiac workload. Its dihydropyridine structure gives it greater affinity for peripheral vessels than for the myocardium.

Side Effects

Nifedipine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache: often transient and mild.
  • Flushing: warm sensation, especially on the face and neck.
  • Peripheral edema: swelling of ankles or lower legs.
  • Dizziness or light‑headedness, particularly on standing.

Serious or Rare Side Effects

  • Severe hypotension: sudden drop in blood pressure requiring medical attention.
  • Myocardial infarction: rare but reported in susceptible patients.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.
  • Allergic reactions: rash, itching, or anaphylaxis.

Precautions & Warnings

  • When prescribing Nifedipine, clinicians should consider several safety measures.
  • Cardiovascular assessment: evaluate baseline blood pressure and heart rate before initiation.
  • Concomitant beta‑blocker therapy: monitor for additive hypotensive effects.
  • Liver impairment: adjust use in patients with severe hepatic dysfunction.
  • Elderly patients: start with lower doses and observe for orthostatic symptoms.
  • Pregnancy and lactation: use only if potential benefit justifies risk.
  • Store at ambient temperature: keep below 25 °C, retain in original container, protect from moisture and light.

Avoid Interactions

Nifedipine can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may markedly increase nifedipine plasma levels.
  • Grapefruit juice: can raise drug concentration leading to hypotension.
  • Concurrent use with other potent vasodilators (e.g., nitroglycerin): risk of severe hypotension.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may blunt compensatory tachycardia, requiring blood pressure monitoring.
  • Diuretics: additive blood pressure‑lowering effect, monitor electrolytes.
  • Antihypertensive combination therapy: adjust dose to avoid excessive hypotension.

Frequently Asked Questions

Nifelat La contains nifedipine, which is prescribed to lower high blood pressure, relieve chest pain caused by angina, and improve blood flow in conditions such as Raynaud's phenomenon. It works by relaxing the smooth muscle in blood vessels, thereby reducing vascular resistance.

Nifedipine blocks L‑type calcium channels on vascular smooth‑muscle cells. By preventing calcium entry, the muscle cannot contract effectively, leading to dilation of arteries, lower peripheral resistance, and a reduction in blood pressure and cardiac workload.

The exact dose of Nifelat La is determined by the prescribing clinician based on the patient’s condition, response, and other medical factors. Healthcare professionals tailor the regimen to achieve optimal blood‑pressure control or angina relief while minimizing side effects.

Safety data for nifedipine in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nifedipine belongs to the dihydropyridine class of calcium‑channel blockers, offering potent arterial vasodilation. Compared with beta‑blockers, it primarily reduces peripheral resistance rather than heart rate, and unlike ACE inhibitors, it does not affect the renin‑angiotensin system. Choice depends on patient profile and comorbidities.

Store Nifelat La at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister pack or container, protect them from moisture, heat and direct sunlight. Do not store in a refrigerator or freezer unless specifically instructed by the supplier.

Nifelat La is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless the prescriber advises otherwise. Dosing frequency and timing are set by the treating physician based on therapeutic goals.

Serious adverse events include severe hypotension, myocardial infarction, hepatic dysfunction, and allergic reactions such as rash or anaphylaxis. Patients should seek immediate medical attention if they experience sudden dizziness, fainting, chest pain, yellowing of the skin or unexplained swelling.

Nifelat La is contraindicated in patients with known hypersensitivity to nifedipine or any other dihydropyridine calcium‑channel blockers. It should also be avoided in individuals with severe aortic stenosis, uncontrolled heart failure, or those taking potent CYP3A4 inhibitors without close monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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