Product image of Nifelat (Nifedipine) supplied by GNH India

Nifelat

Active Ingredient:
Nifedipine
Origin:
EU

Nifelat (Nifedipine)

Nifedipine, the active ingredient in Nifelat, is a calcium channel blocker presented as an oral tablet for systemic use. It is employed to lower high blood pressure, relieve chest pain from angina, and improve blood flow in Raynaud's phenomenon, primarily in adult patients.

GNH India supplies Nifelat as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for regulated markets. Its distribution network ensures timely delivery across Europe, Asia, Africa and the Americas.

Manufacturer / TM Owner

Remedica Ltd

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Indications & Clinical Uses

Nifedipine is a dihydropyridine calcium channel blocker used to manage vascular and cardiac conditions.

  • Hypertension: reduces peripheral resistance and lowers blood pressure.
  • Angina pectoris: improves coronary blood flow and relieves chest pain.
  • Raynaud's phenomenon: alleviates vasospasm and enhances peripheral circulation.

How It Works

  • Nifedipine selectively inhibits L‑type calcium channels in vascular smooth muscle and cardiac myocytes. By preventing calcium influx, it promotes relaxation of arterial smooth muscle, leading to vasodilation and decreased systemic vascular resistance. The resulting reduction in afterload lowers blood pressure and improves myocardial oxygen supply, while coronary artery dilation mitigates anginal episodes. Its effect is dose‑dependent and more pronounced in peripheral arteries than in the coronary circulation.

Side Effects

Nifedipine may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Headache: mild to moderate headache often after the first dose.
  • Flushing: transient warmth and redness of the skin.
  • Peripheral edema: swelling of the ankles or lower legs.

Serious or Rare Side Effects

  • Hypotension: marked drop in blood pressure that may cause fainting.
  • Reflex tachycardia: rapid heart rate in response to vasodilation.
  • Severe allergic reaction: rash, itching, swelling, or difficulty breathing.

Precautions & Warnings

When prescribing Nifedipine, clinicians should consider several precautionary measures to ensure safe use.

  • Blood pressure monitoring: check baseline and periodic readings to avoid excessive hypotension.
  • Concomitant cardiac disease: use cautiously in patients with severe aortic stenosis or heart failure.
  • Grapefruit products: avoid because they can increase nifedipine plasma levels.
  • Liver impairment: dose adjustment may be required in moderate to severe hepatic dysfunction.
  • Pregnancy and lactation: use only if clearly needed; risk to fetus is not well established.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and light.

Avoid Interactions

Nifedipine can interact with several medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may cause dangerous accumulation.
  • Simultaneous use with other potent vasodilators (e.g., nitroglycerin): risk of severe hypotension.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce therapeutic effect.
  • Beta‑blockers: may blunt compensatory heart rate increase.
  • Diuretics: may enhance orthostatic hypotension.

Frequently Asked Questions

Nifelat contains nifedipine, which is prescribed for hypertension (high blood pressure), angina pectoris (chest pain due to reduced coronary blood flow), and Raynaud's phenomenon (vasospasm of peripheral arteries). These indications reflect its ability to relax vascular smooth muscle and improve blood circulation.

Nifedipine blocks L‑type calcium channels on arterial smooth‑muscle cells, preventing calcium entry that is necessary for contraction. This causes the arteries to relax and dilate, decreasing systemic vascular resistance and, consequently, lowering arterial blood pressure.

The exact dose of Nifelat is individualized by the prescribing clinician based on the patient’s medical condition, response to therapy, age, renal and hepatic function, and any concomitant medications. No fixed regimen is provided here; the prescriber sets the appropriate strength and frequency.

The safety of nifedipine in pregnancy and lactation has not been definitively established. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified health professional.

To request Nifelat, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Nifelat (nifedipine) belongs to the dihydropyridine calcium‑channel blocker class, which primarily causes arterial vasodilation. Compared with beta‑blockers or ACE inhibitors, it has a rapid onset of vasodilatory effect and is especially useful when a strong peripheral‑vascular action is desired, but it may be associated with reflex tachycardia.

Nifelat should be stored at ambient temperature, preferably below 25 °C, in its original packaging. The container should be kept tightly closed, protected from moisture and light, and kept out of reach of children.

Nifelat is taken orally, usually with a full glass of water. It may be taken with or without food, but patients should follow the specific instructions given by their prescriber to maintain consistent plasma levels and minimize side‑effects.

The most serious adverse events include severe hypotension, reflex tachycardia, and rare but potentially life‑threatening allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience fainting, rapid heartbeat, difficulty breathing, or swelling of the face and throat.

Nifelat is contraindicated in patients with known hypersensitivity to nifedipine or other dihydropyridine calcium‑channel blockers, in those with severe aortic stenosis, and in individuals with cardiogenic shock. Caution is also advised for patients with significant liver impairment or who are taking strong CYP3A4 inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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