Product image of Nifelat R (Nifedipine) supplied by GNH India

Nifelat R

Active Ingredient:
Nifedipine
Origin:
EU

Nifelat R (Nifedipine)

Nifedipine, the active ingredient in Nifelat R, is a calcium channel blocker presented as an oral dosage form for oral use. It treats hypertension and angina pectoris in adult patients.\n\nGNH India supplies Nifelat R as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Remedica Ltd

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Indications & Clinical Uses

  • Nifelat R belongs to the calcium channel blocker class and is used in cardiovascular conditions where vascular tone needs to be reduced.\n\nHypertension: lowers systemic blood pressure by relaxing arterial smooth muscle.\nAngina pectoris: reduces frequency and severity of chest pain by improving coronary blood flow.

How It Works

  • Nifedipine selectively inhibits L‑type calcium channels in vascular smooth muscle, decreasing intracellular calcium influx. This leads to relaxation of arterial smooth muscle, vasodilation, reduced peripheral vascular resistance, and consequently lower blood pressure and myocardial oxygen demand.

Side Effects

  • Nifedipine may cause a range of adverse reactions that vary in frequency and severity.\n\nCommon Side Effects:\n- Headache\n- Flushing\n- Peripheral edema\n- Dizziness\n\nSerious or Rare Side Effects:\n- Severe hypotension\n- Myocardial infarction\n- Hepatic dysfunction or jaundice

Precautions & Warnings

  • Before prescribing Nifelat R, clinicians should consider several safety measures.\n\nMonitor blood pressure regularly: ensure therapeutic effect without excessive drop.\nAvoid abrupt discontinuation: taper to prevent rebound hypertension.\nUse caution in hepatic impairment: metabolism is hepatic, dose may need adjustment.\nUse caution in patients with heart failure: risk of worsening symptoms.\nUse caution in elderly patients: increased sensitivity to hypotensive effects.\nStore at room temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

  • Nifedipine can interact with several medicines, altering its efficacy or safety.\n\nMajor Interactions (Avoid):\n- Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may cause toxic levels.\n- Grapefruit juice: increases plasma concentration, raising risk of hypotension.\n- High‑dose simvastatin (>20 mg): risk of rhabdomyolysis.\n\nModerate Interactions (Monitor Closely):\n- Beta‑blockers: additive heart rate reduction.\n- Diuretics: may enhance blood pressure lowering.\n- Digoxin: increased serum digoxin levels, monitor for toxicity.

Frequently Asked Questions

Nifelat R contains nifedipine, a calcium channel blocker prescribed primarily for managing hypertension and for relieving angina pectoris. It works by relaxing blood vessels, which helps lower blood pressure and improves blood flow to the heart.

Nifedipine blocks L‑type calcium channels in the smooth muscle of arteries. By preventing calcium entry, it causes the muscles to relax, leading to vasodilation, reduced peripheral resistance, lower blood pressure, and decreased cardiac workload.

The specific dose of Nifelat R is determined by the prescribing clinician based on the patient’s condition, response, and other medical factors. Dosage adjustments are made individually and should follow the prescriber’s instructions.

Safety data for nifedipine in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nifelat R (nifedipine) is a dihydropyridine calcium channel blocker, distinct from beta‑blockers, ACE inhibitors, or diuretics. It is particularly effective for patients who need rapid vasodilation, but may cause peripheral edema more often than some other classes.

Nifelat R should be stored at room temperature, below 25 °C, in its original packaging. Keep it away from moisture and direct sunlight to maintain product stability.

Nifelat R is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the prescribing clinician’s guidance on timing and any dietary considerations.

Serious risks include severe hypotension, myocardial infarction, and rare cases of hepatic dysfunction. Patients should be monitored for signs of these conditions, especially during dose initiation or when combined with interacting medications.

Nifelat R is contraindicated in patients with known hypersensitivity to nifedipine or any component of the formulation, and in those with severe aortic stenosis or uncontrolled heart failure. Clinicians should assess each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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