Product image of Niferex (Ferrous (Ii) Glycine Sulfate Complex) supplied by GNH India

Niferex

Active Ingredient:
Ferrous (Ii) Glycine Sulfate Complex
Origin:
EU

Niferex (Ferrous (Ii) Glycine Sulfate Complex)

Ferrous (II) Glycine Sulfate Complex, the active ingredient in Niferex, is an iron supplement presented as an oral formulation for systemic use. It is employed to prevent and treat iron deficiency and to support normal hemoglobin levels in individuals with low iron stores.

GNH India supplies Niferex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution. Customers benefit from reliable supply chains and responsive technical support.

Manufacturer / TM Owner

Ucb Pharma S.P.A.

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Indications & Clinical Uses

  • Niferex, an oral iron supplement, is used to address conditions related to insufficient iron availability.
  • Iron deficiency anemia: restores hemoglobin concentration and alleviates fatigue.
  • Pregnancy‑associated iron deficiency: supports maternal iron stores and fetal development.
  • Pediatric iron deficiency: promotes normal growth and cognitive development in children with low iron.
  • Chronic kidney disease‑related anemia: contributes to iron repletion as part of anemia management.
  • Heart failure‑related iron deficiency: improves exercise capacity and quality of life.
  • Post‑surgical blood loss: aids recovery of iron stores after operative procedures.

How It Works

  • Ferrous (II) Glycine Sulfate Complex dissociates in the gastrointestinal tract, releasing ferrous iron that is readily absorbed via the divalent metal transporter‑1 (DMT‑1) in the duodenal epithelium. The absorbed iron enters the bloodstream, binds to transferrin, and is delivered to the bone marrow for incorporation into heme, facilitating hemoglobin synthesis and replenishing tissue iron stores. Its glycine‑sulfate ligand enhances solubility, improving bioavailability compared with some inorganic iron salts.

Side Effects

Oral administration of ferrous iron may be associated with several adverse reactions, ranging from mild gastrointestinal symptoms to rare serious events.

Common Side Effects

  • Nausea: mild queasiness often occurring after the dose.
  • Constipation or diarrhea: changes in bowel habits are frequently reported.
  • Abdominal discomfort: cramping or pain in the stomach region.
  • Darkened stools: harmless discoloration of feces due to iron.

Serious or Rare Side Effects

  • Severe allergic reaction: hives, swelling, or difficulty breathing requiring immediate medical attention.
  • Iron overload: signs include fatigue, joint pain, or organ dysfunction, typically with excessive dosing.
  • Hypotension: sudden drop in blood pressure may occur, especially if taken on an empty stomach.

Precautions & Warnings

  • When using Niferex, certain precautions help minimize risks and ensure optimal efficacy.
  • Assess iron status: confirm deficiency with laboratory tests before initiating therapy.
  • Monitor hemoglobin: periodic blood counts are recommended to track response.
  • Take with food: ingestion with meals reduces gastrointestinal irritation.
  • Avoid concurrent antacids: calcium or magnesium‑containing products can impair iron absorption.
  • Use in children under medical supervision: dosage must be individualized by a healthcare professional.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ferrous (II) Glycine Sulfate Complex can affect the absorption or activity of several other medicines.

Major Interactions (Avoid)

  • Tetracycline antibiotics: chelation reduces effectiveness of both agents.
  • Fluoroquinolones: concurrent use markedly decreases antibiotic absorption.
  • Levothyroxine: iron interferes with thyroid hormone uptake, requiring separation of dosing.

Moderate Interactions (Monitor Closely)

  • Proton pump inhibitors: reduced gastric acidity may lower iron absorption.
  • Calcium supplements or dairy products: can diminish iron uptake if taken together.
  • Antacids containing aluminum or magnesium: may modestly impair iron absorption.

Frequently Asked Questions

Niferex contains ferrous (II) glycine sulfate complex, an oral iron supplement used to prevent and treat iron deficiency and to support normal hemoglobin levels in patients with low iron stores, including those with anemia, pregnancy‑related deficiency, or chronic disease‑associated iron loss.

The complex releases ferrous iron in the gut, which is absorbed through the divalent metal transporter‑1 (DMT‑1) in the duodenum. Once in the bloodstream, iron binds to transferrin and is delivered to the bone marrow for heme synthesis, thereby increasing hemoglobin production and replenishing body iron stores.

The appropriate dose of Niferex is determined by a prescriber based on the individual’s iron status, age, weight, and clinical condition. Healthcare professionals consider laboratory results and patient factors before recommending a specific regimen.

Iron supplementation is often recommended during pregnancy and lactation when deficiency is present, but the decision to use Niferex should be made by a qualified healthcare provider. The prescriber will weigh potential benefits against any risks specific to the mother and infant.

To place an order, submit an enquiry on the Niferex product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Niferex delivers iron as a ferrous (II) glycine sulfate complex, which offers high solubility and bioavailability compared with some inorganic iron salts. This may result in more efficient absorption and potentially fewer gastrointestinal side effects, though individual response can vary and should be monitored by a clinician.

Store Niferex at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability and potency.

Niferex is taken orally, usually with a full glass of water. For optimal absorption, it is often recommended to take the supplement on an empty stomach, but if gastrointestinal irritation occurs, it may be taken with a small amount of food. Follow the prescriber’s instructions regarding timing and any necessary separation from other medications.

The most serious risks include severe allergic reactions such as hives, swelling, or breathing difficulties, and iron overload, which can cause organ damage if excessive doses are taken over a prolonged period. Prompt medical attention is required if any signs of anaphylaxis or symptoms of iron toxicity appear.

Niferex should be avoided by individuals with known hypersensitivity to ferrous iron or any component of the formulation, and by patients with conditions predisposing them to iron overload (e.g., hereditary hemochromatosis) unless specifically directed by a physician. Consultation with a healthcare professional is essential before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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