Niferex (Ferrous (Ii) Glycine Sulfate Complex)

Niferex is an iron supplement that addresses conditions related to insufficient iron availability.

• Iron deficiency anemia: restores normal hemoglobin levels and improves red blood cell production.
• Prevention of iron deficiency: maintains adequate iron stores in at‑risk populations such as menstruating women and children.
• Chronic blood loss: supports replenishment of iron lost through gastrointestinal bleeding or other chronic losses.

• Ferrous (II) Glycine Sulfate Complex provides bioavailable ferrous iron that is readily absorbed in the duodenum. The absorbed iron enters the bloodstream, where it is incorporated into hemoglobin and myoglobin, facilitating erythropoiesis and supporting cellular oxygen transport and metabolic processes.

Niferex may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

• Nausea: mild stomach upset after ingestion.
• Constipation: reduced bowel movements.
• Dark stools: harmless discoloration of feces.
• Abdominal discomfort: cramping or mild pain.
• Metallic taste: transient alteration in taste perception.

Serious or Rare Side Effects

• Severe allergic reaction: rash, swelling, or difficulty breathing.
• Hemochromatosis exacerbation: signs of iron overload such as joint pain or organ dysfunction.
• Persistent vomiting: may lead to dehydration or electrolyte imbalance.

When using Niferex, consider the following safety measures.

• Assess iron status: confirm deficiency before initiating therapy.
• Monitor gastrointestinal tolerance: advise patients to take with food if upset occurs.
• Avoid excess dosing: high iron intake can cause toxicity.
• Caution in renal impairment: adjust monitoring as needed.
• Pregnancy and lactation: use only if prescribed after risk‑benefit evaluation.
• Store at ambient temperature: keep below 25°C in the original container, protect from moisture and direct sunlight.

Niferex can affect the absorption or activity of several other agents.

Major Interactions (Avoid)

• Tetracycline antibiotics: chelation reduces absorption of both drugs.
• Fluoroquinolones: concurrent intake may diminish antibiotic efficacy.
• Levothyroxine: iron may impair thyroid hormone absorption.

Moderate Interactions (Monitor Closely)

• Antacids containing aluminum or magnesium: may decrease iron uptake.
• Proton pump inhibitors: reduced gastric acidity can lower iron absorption.
• Vitamin C supplements: may increase iron absorption, requiring dose adjustment.