Product image of Niflactol (Niflumic Acid) supplied by GNH India

Niflactol

Active Ingredient:
Niflumic Acid
Origin:
EU

Niflactol (Niflumic Acid)

Niflumic Acid, the active ingredient in Niflactol, is a fenamate presented as an oral formulation for oral use. It belongs to the nonsteroidal anti‑inflammatory drug class and is used to relieve pain and reduce inflammation in musculoskeletal and other inflammatory conditions by inhibiting cyclooxygenase enzymes and decreasing prostaglandin synthesis.

GNH India supplies Niflactol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets.

Manufacturer / TM Owner

Upsa Sas

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Indications & Clinical Uses

Niflumic Acid is indicated for conditions involving pain and inflammation within the musculoskeletal and rheumatologic disease spectrum.

  • Pain relief: Provides analgesic effect in acute and chronic pain conditions.
  • Inflammation reduction: Decreases inflammatory response in soft tissue and joint disorders.
  • Musculoskeletal disorders: Improves mobility and reduces swelling in conditions such as osteoarthritis and rheumatoid arthritis.

How It Works

  • Niflumic Acid exerts its anti‑inflammatory and analgesic actions by non‑selectively inhibiting cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis diminishes peripheral sensitisation of nociceptors and lowers vascular permeability, thereby alleviating pain, edema and inflammation associated with musculoskeletal and other inflammatory conditions.

Side Effects

Niflumic Acid may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: Nausea, dyspepsia or abdominal pain.
  • Headache: Mild to moderate intensity.
  • Dizziness: Transient sensation of light‑headedness.

Serious or Rare Side Effects

  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatic injury: Elevated liver enzymes or hepatitis.
  • Renal impairment: Acute kidney injury or reduced renal function.
  • Blood dyscrasias: Agranulocytosis, leukopenia or thrombocytopenia.
  • Anaphylaxis: Immediate hypersensitivity reaction.

Precautions & Warnings

When prescribing Niflumic Acid, clinicians should consider several precautionary measures to minimise risk.

  • Assess renal function: Evaluate kidney status before initiation and monitor periodically.
  • Monitor hepatic enzymes: Check liver function tests due to potential hepatotoxicity.
  • Avoid in known hypersensitivity: Do not use in patients with previous allergic reactions to fenamates or other NSAIDs.
  • Use caution in elderly: Reduced renal clearance may increase adverse effects.
  • Concomitant anticoagulant use: Increase bleeding risk; monitor coagulation parameters.
  • Store at ambient temperature: Keep below 25 °C in the original container, protected from moisture and direct sunlight.

Avoid Interactions

Niflumic Acid can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid)

  • Other NSAIDs: Combined use markedly raises risk of gastrointestinal bleeding.
  • Anticoagulants: Potentiates anticoagulant effect, increasing hemorrhage risk.
  • Lithium: May raise lithium serum concentrations, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: Additive risk of ulceration and gastrointestinal complications.
  • ACE inhibitors: May reduce renal perfusion, especially in volume‑depleted patients.
  • Diuretics: Potential for decreased renal function and electrolyte imbalance.

Frequently Asked Questions

Niflactol contains Niflumic Acid, a fenamate NSAID that is employed to relieve moderate to severe pain, reduce inflammation, and improve function in musculoskeletal conditions such as osteoarthritis, rheumatoid arthritis and other inflammatory joint disorders.

Niflumic Acid works by non‑selectively inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which blocks the synthesis of prostaglandins from arachidonic acid. Lower prostaglandin levels reduce peripheral sensitisation of pain receptors and diminish inflammatory swelling and heat.

The appropriate dose of Niflactol is determined by the prescribing clinician based on the patient’s condition, age, renal and hepatic function, and response to therapy. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for Niflumic Acid in pregnancy and lactation are limited. It should only be used when the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Niflactol, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Niflactol belongs to the fenamate subclass of NSAIDs, which tend to have a broader COX inhibition profile compared with selective COX‑2 inhibitors. Its analgesic and anti‑inflammatory potency is comparable to other non‑selective NSAIDs, but individual tolerability and drug‑interaction profiles may differ.

Niflactol should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the product out of reach of children and avoid storing in damp or excessively hot environments.

Niflactol is administered orally. The tablets (or other oral dosage form) are taken with a full glass of water, preferably with food or after a meal to minimise gastrointestinal irritation, unless otherwise directed by the prescriber.

Serious risks include severe skin reactions such as Stevens‑Johnson syndrome, hepatic injury, acute renal impairment, blood dyscrasias like agranulocytosis, and anaphylactic reactions. Patients should seek immediate medical attention if they experience rash, jaundice, sudden kidney problems, unexplained bruising or signs of an allergic reaction.

Niflactol should be avoided in individuals with known hypersensitivity to fenamates or other NSAIDs, those with active gastrointestinal ulcers, severe renal or hepatic impairment, and patients receiving anticoagulant therapy where bleeding risk is high, unless a healthcare professional determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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