Product image of Niflugel (Niflumic Acid) supplied by GNH India

Niflugel

Active Ingredient:
Niflumic Acid
Origin:
EU

Niflugel (Niflumic Acid)

Niflumic Acid, the active ingredient in Niflugel, is a fenamate (NSAID) presented as a topical gel for topical use. It provides anti‑inflammatory and analgesic effects for musculoskeletal discomfort in adults.

GNH India supplies Niflugel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Upsa Sas

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Indications & Clinical Uses

  • Niflugel, a topical fenamate NSAID, is applied to conditions involving inflammation and pain in the musculoskeletal system.
  • Musculoskeletal pain: reduces localized pain and swelling in muscles and joints.
  • Rheumatoid arthritis flare: alleviates joint inflammation and discomfort when applied to affected areas.
  • Osteoarthritis of the knee: provides topical relief of pain and stiffness associated with degenerative joint disease.

How It Works

  • Niflumic Acid inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes, decreasing prostaglandin synthesis and thereby reducing inflammation. It also blocks certain chloride channels in peripheral tissues, contributing to its analgesic and anti‑inflammatory actions when applied topically.

Side Effects

Topical application of Niflugel may cause local and systemic adverse reactions.

Common Side Effects

  • Skin irritation: redness, burning, or stinging at the application site.
  • Itching or pruritus.
  • Dryness or peeling of the skin.
  • Contact dermatitis.
  • Mild erythema.
  • Localized swelling.

Serious or Rare Side Effects

  • Systemic gastrointestinal ulceration or bleeding.
  • Renal impairment, especially with extensive use.
  • Severe hypersensitivity reactions such as Stevens‑Johnson syndrome.
  • Anaphylactic shock.
  • Hepatotoxicity.
  • Blood dyscrasias (e.g., agranulocytosis).

Precautions & Warnings

  • When using Niflugel, consider the following safety measures.
  • Avoid use on broken or infected skin: may increase systemic absorption.
  • Do not apply near eyes or mucous membranes: risk of irritation.
  • Limit duration to the period prescribed by a healthcare professional.
  • Concurrent systemic NSAIDs: discuss with a physician to avoid additive toxicity.
  • Pregnancy and lactation: use only if clearly indicated and under medical supervision.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Niflugel can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Systemic NSAIDs: increased risk of gastrointestinal bleeding.
  • Anticoagulants (e.g., warfarin, DOACs): heightened bleeding tendency.

Moderate Interactions (Monitor Closely)

  • Diuretics: may affect renal function when combined with NSAIDs.
  • ACE inhibitors or ARBs: monitor renal parameters.
  • Lithium: potential increase in lithium serum levels.
  • Corticosteroids: additive risk of skin thinning and ulceration.

Frequently Asked Questions

Niflugel is a topical gel containing Niflumic Acid, a fenamate NSAID. It is used to relieve pain and reduce inflammation in musculoskeletal conditions such as muscle strains, joint pain, rheumatoid arthritis flares, and osteoarthritis when applied to the affected skin area.

Niflumic Acid works by inhibiting cyclooxygenase enzymes, which lowers prostaglandin production and thus reduces inflammation. Additionally, it blocks specific chloride channels in peripheral tissues, contributing to its analgesic effect when applied topically.

The dosage of Niflugel is determined by the prescribing healthcare professional based on the patient’s condition, severity, and treatment response. The prescriber will specify the amount to apply, frequency, and duration of therapy.

Safety of Niflugel in pregnancy or while breastfeeding has not been fully established. It should be used only if the potential benefit justifies the potential risk, and this decision must be made by a qualified healthcare provider.

To order Niflugel, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details, and import documentation.

Niflugel contains Niflumic Acid, a fenamate class NSAID, which differs chemically from more common topical NSAIDs such as diclofenac or ibuprofen. Fenamates may offer a distinct anti‑inflammatory profile and are sometimes preferred for patients who respond better to this subclass, though clinical choice depends on efficacy, tolerability, and physician judgment.

Store Niflugel at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and avoid freezing. Ensure the product is kept out of reach of children.

Niflugel is applied topically to clean, dry skin over the affected area. The prescribed amount is spread in a thin layer and gently massaged until absorbed. Hands should be washed after application, and the gel should not be covered with occlusive dressings unless directed by a clinician.

Serious risks include systemic gastrointestinal ulceration or bleeding, renal impairment, severe hypersensitivity reactions such as Stevens‑Johnson syndrome, and anaphylaxis. Patients should seek immediate medical attention if they experience severe skin reactions, unexplained bleeding, or signs of systemic toxicity.

Niflugel should not be used by individuals with known hypersensitivity to Niflumic Acid or other fenamate NSAIDs, on broken or infected skin, or in patients where systemic NSAID use is contraindicated, such as those with active peptic ulcer disease, severe renal impairment, or uncontrolled bleeding disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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