Product image of Niflugel (Niflumic Acid) supplied by GNH India

Niflugel

Active Ingredient:
Niflumic Acid
Origin:
EU

Niflugel (Niflumic Acid)

Niflumic Acid, the active ingredient in Niflugel, is a fenamate (non‑steroidal anti‑inflammatory drug) presented as a topical gel for local anti‑inflammatory use. The preparation is intended for external application to skin or ocular surfaces, where it helps to reduce prostaglandin‑mediated pain, swelling and erythema in musculoskeletal and eye‑related inflammatory conditions.

GNH India supplies Niflugel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing for regulated markets across Europe, Asia, the Americas and the Middle East.

Manufacturer / TM Owner

Upsa Sas

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Indications & Clinical Uses

Niflugel, a topical NSAID, is employed to manage inflammatory conditions of the musculoskeletal and ocular systems.

  • Musculoskeletal pain: provides local relief of pain and inflammation in muscles, tendons and joints.
  • Tendinitis: reduces swelling and discomfort associated with inflamed tendons.
  • Bursitis: alleviates inflammation of bursae surrounding joints.
  • Allergic conjunctivitis: helps relieve ocular redness, itching and swelling caused by allergic reactions.

How It Works

  • Niflumic Acid inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain and fever. In addition, it blocks voltage‑gated chloride channels in peripheral sensory neurons, which contributes to its analgesic effect. The combined inhibition of prostaglandin production and chloride‑channel activity results in reduced vascular permeability, edema and nociceptive signaling at the site of topical application.

Side Effects

Topical application of Niflugel may be associated with local and systemic adverse reactions.

Common Side Effects

  • Skin irritation: mild redness or itching at the application site.
  • Burning sensation: transient warmth or stinging when first applied.
  • Dryness: localized skin dryness or flaking.
  • Pruritus: itching that may develop after repeated use.

Serious or Rare Side Effects

  • Contact dermatitis: severe allergic skin reaction with swelling and vesicles.
  • Systemic NSAID effects: rare gastrointestinal ulceration or bleeding.
  • Renal impairment: unlikely but possible in susceptible individuals.
  • Anaphylaxis: life‑threatening allergic response requiring immediate medical attention.

Precautions & Warnings

When using Niflugel, certain precautions should be observed to minimize risks.

  • Allergy assessment: confirm no known hypersensitivity to fenamates or other NSAIDs.
  • Application area: limit use to intact skin or ocular surface; avoid broken skin or mucosa.
  • Concomitant NSAIDs: avoid simultaneous use of systemic NSAIDs to reduce cumulative toxicity.
  • Pregnancy and lactation: use only if clearly indicated after risk‑benefit evaluation by a healthcare professional.
  • Age considerations: exercise caution in pediatric and elderly patients due to altered skin absorption.
  • Store at room temperature: keep below 25 °C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Niflugel can interact with other medicines; awareness of these interactions helps ensure safe use.

Major Interactions (Avoid)

  • Systemic NSAIDs: combined use may increase risk of gastrointestinal bleeding and renal toxicity.
  • Anticoagulants/antiplatelet agents: heightened potential for bleeding complications.
  • Corticosteroids: additive risk of skin thinning and delayed wound healing.

Moderate Interactions (Monitor Closely)

  • Lithium: NSAIDs may raise lithium serum levels, requiring monitoring.
  • Methotrexate: concurrent NSAIDs can reduce renal clearance of methotrexate.
  • Diuretics: possible reduction in renal perfusion, necessitating renal function checks.

Frequently Asked Questions

Niflugel is a topical formulation containing niflumic acid that is used to relieve pain and inflammation in musculoskeletal conditions such as muscle aches, tendonitis and bursitis, as well as to treat allergic conjunctivitis of the eye. It provides local anti‑inflammatory effects when applied to the affected area.

Niflumic acid works by inhibiting cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the production of prostaglandins that cause inflammation and pain. It also blocks voltage‑gated chloride channels in peripheral nerves, contributing to analgesia. The dual action diminishes swelling, redness and discomfort at the site of application.

The appropriate dose of Niflugel is determined by the prescribing healthcare professional based on the specific condition, severity, patient age and treatment area. No fixed dosing regimen is provided here; patients should follow the instructions given by their prescriber and the product label.

Safety data for topical niflumic acid in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider after a thorough risk‑benefit assessment.

To order Niflugel, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials. The sales team will then respond with pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Niflugel contains niflumic acid, a fenamate class NSAID, which offers both cyclooxygenase inhibition and chloride‑channel blockade. Compared with more common topical NSAIDs such as diclofenac or ibuprofen gels, niflumic acid may provide additional analgesic benefit through its unique ion‑channel activity, though clinical choice depends on physician preference, patient tolerance and regulatory availability.

Store Niflugel at room temperature, preferably below 25 °C, in its original packaging. Protect the container from moisture, direct sunlight and extreme temperatures. Keep the product out of reach of children and avoid freezing. If the gel appears discoloured or the seal is broken, discard it.

Apply a thin layer of Niflugel to the clean, dry skin over the affected area, gently massaging until absorbed. For ocular use, follow the specific instructions on the label or as directed by a clinician. Do not cover the treated area with occlusive dressings unless advised, and wash your hands after application.

The most serious risks include severe allergic reactions such as contact dermatitis or anaphylaxis, and systemic NSAID‑related effects like gastrointestinal bleeding, ulceration or renal impairment, especially when used together with other NSAIDs or in patients with pre‑existing kidney disease.

Niflugel should be avoided in individuals with known hypersensitivity to niflumic acid, other fenamates, or any component of the formulation. It is also contraindicated in patients with severe renal or hepatic impairment, active gastrointestinal ulcer disease, or those receiving systemic anticoagulants without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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