Product image of Nifluril Enfants (Morniflumate) supplied by GNH India

Nifluril Enfants

Active Ingredient:
Morniflumate
Origin:
EU

Nifluril Enfants (Morniflumate)

Morniflumate, the active ingredient in Nifluril Enfants, is a fenamate NSAID presented as a rectal formulation for rectal use. It is employed to relieve pain and inflammation associated with musculoskeletal disorders in children and adolescents, providing anti‑inflammatory and analgesic effects where oral options are unsuitable.

GNH India supplies Nifluril Enfants as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with distribution across the European Union and other regulated markets. The company ensures quality and regulatory compliance throughout the supply chain.

Manufacturer / TM Owner

Upsa Sas

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Indications & Clinical Uses

Morniflumate is used to manage conditions involving pain and inflammation within the musculoskeletal system.

  • Pain: Reduces acute and chronic pain associated with musculoskeletal injuries.
  • Inflammation: Decreases inflammatory swelling in joints and soft tissues.
  • Musculoskeletal disorders: Improves functional mobility and comfort in conditions such as sprains, strains and juvenile arthritis.

How It Works

  • Morniflumate exerts its anti‑inflammatory and analgesic actions by non‑selectively inhibiting cyclooxygenase (COX‑1 and COX‑2) enzymes, which reduces the synthesis of prostaglandins that mediate pain, fever and inflammation. The decreased prostaglandin levels lead to diminished peripheral sensitisation of nociceptors and lower inflammatory exudate formation at the site of injury.

Side Effects

Morniflumate may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal irritation: mild abdominal discomfort or dyspepsia.
  • Nausea: occasional feeling of queasiness.
  • Headache: transient mild headache.
  • Local irritation: mild rectal burning or itching.

Serious or Rare Side Effects

  • Ulceration or bleeding: gastrointestinal ulcer or hemorrhage.
  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Renal impairment: reduced kidney function or acute renal failure.
  • Severe allergic reaction: rash, angioedema or anaphylaxis.

Precautions & Warnings

When prescribing Morniflumate, several precautions should be observed to minimise risk.

  • Assess renal function: evaluate kidney status before initiating therapy.
  • Monitor hepatic health: check liver enzymes in patients with liver disease.
  • Use caution in elderly: increased susceptibility to NSAID‑related adverse events.
  • Avoid concurrent ulcerogenic drugs: limit use with other NSAIDs, corticosteroids or anticoagulants.
  • Pregnancy and lactation: contraindicated or use only if benefits outweigh risks.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in original packaging.

Avoid Interactions

Morniflumate can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Other NSAIDs: additive risk of gastrointestinal bleeding.
  • Anticoagulants (e.g., warfarin): increased bleeding tendency.
  • Corticosteroids: heightened ulcer risk.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in renal function.
  • Diuretics: risk of electrolyte imbalance and renal impairment.
  • Lithium: increased lithium levels leading to toxicity.

Frequently Asked Questions

Nifluril Enfants contains Morniflumate, a fenamate NSAID that is used to relieve pain and reduce inflammation associated with musculoskeletal conditions such as sprains, strains, and juvenile arthritis. It provides an alternative route of administration when oral NSAIDs are not suitable.

Morniflumate works by non‑selectively inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2. This inhibition lowers the production of prostaglandins, which are mediators of pain, fever, and inflammation, thereby producing analgesic and anti‑inflammatory effects at the site of injury.

The appropriate dose of Nifluril Enfants is determined by the prescribing healthcare professional based on the patient’s age, weight, clinical condition, and response to therapy. Dosage instructions are provided on the prescription label and should be followed exactly as directed.

Safety of Morniflumate in pregnancy and lactation has not been firmly established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Morniflumate belongs to the fenamate subclass of NSAIDs, which differs chemically from more common propionic or acetic acid NSAIDs. It offers a rectal route that can be advantageous when oral administration is problematic, but its safety profile and drug‑interaction potential are similar to other non‑selective NSAIDs.

Store Nifluril Enfants at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the rectal dosage form is not damaged before use.

Nifluril Enfants is administered rectally. The prescribed dose is inserted into the rectum according to the instructions provided by the healthcare professional, usually using a suitable applicator or as directed on the product label.

Serious risks include gastrointestinal ulceration or bleeding, liver injury (hepatotoxicity), renal impairment, and severe allergic reactions such as anaphylaxis. Patients should be monitored for signs of abdominal pain, dark stools, jaundice, reduced urine output, or rash, and seek medical attention promptly if they occur.

Nifluril Enfants should be avoided in patients with known hypersensitivity to Morniflumate or other fenamate NSAIDs, active gastrointestinal ulceration, severe renal or hepatic impairment, and in those where NSAID use is contraindicated, such as certain cardiovascular conditions without medical guidance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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