Product image of Nifuretten (Nitrofurantoin Monohydrate) supplied by GNH India

Nifuretten

Active Ingredient:
Nitrofurantoin Monohydrate
Origin:
EU

Nifuretten (Nitrofurantoin Monohydrate)

Nitrofurantoin Monohydrate, the active ingredient in Nifuretten, is a nitrofuran antibiotic presented as a tablet for oral use. It is indicated for the treatment of uncomplicated urinary tract infections in adult patients.
GNH India supplies Nifuretten as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Apogepha Arzneimittel Gmbh

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Indications & Clinical Uses

Nifuretten, a nitrofuran antibiotic, is used to manage infections of the urinary tract.

  • Uncomplicated urinary tract infection: eradicates the causative bacteria and relieves symptoms.
  • Acute cystitis: provides rapid bacterial clearance in bladder infection.
  • Recurrent urinary tract infection prophylaxis: reduces the frequency of future infections when taken as prescribed.

How It Works

  • Nitrofurantoin is reduced by bacterial flavoproteins to reactive intermediates that bind bacterial DNA, ribosomal proteins and other macromolecules. This damage impairs nucleic acid synthesis and other essential processes, leading to inhibition of bacterial growth and bacterial cell death in susceptible urinary pathogens.

Side Effects

Nifuretten may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Loss of appetite: reduced desire to eat.
  • Headache: transient cranial discomfort.
  • Diarrhea: loose stools, usually self‑limiting.
  • Dull abdominal pain: mild cramping in the abdomen.
  • Urine discoloration: brownish tint without clinical significance.

Serious or Rare Side Effects

  • Pulmonary toxicity: interstitial lung disease or acute respiratory distress.
  • Hepatotoxicity: elevated liver enzymes or hepatitis.
  • Hemolytic anemia: especially in patients with G6PD deficiency.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Before prescribing Nifuretten, consider the following precautions.

  • Renal function assessment: evaluate creatinine clearance, as reduced renal function limits drug excretion.
  • Pregnancy safety: category B, use only if benefits outweigh potential risks.
  • Breastfeeding guidance: monitor infant for signs of gastrointestinal upset.
  • G6PD deficiency screening: avoid in patients with known deficiency due to risk of hemolysis.
  • Drug hypersensitivity: discontinue if allergic reactions occur.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Nitrofurantoin may interact with several medicines.

Major Interactions (Avoid)

  • Antacids containing magnesium or aluminum: reduce absorption of nitrofurantoin.
  • Probenecid: decreases renal clearance, increasing plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Fluoroquinolones: additive risk of tendon toxicity.
  • Warfarin: may enhance anticoagulant effect, monitor INR.
  • Diuretics: may exacerbate dehydration, monitor renal function.

Frequently Asked Questions

Nifuretten contains nitrofurantoin and is used to treat uncomplicated urinary tract infections and to prevent recurrent infections in adults. It works by eliminating the bacteria that cause bladder infections.

Nitrofurantoin is reduced by bacterial enzymes to reactive compounds that damage bacterial DNA and other macromolecules, inhibiting bacterial replication and leading to bacterial cell death, particularly in the urinary tract.

The appropriate dose of Nifuretten is determined by the prescribing clinician based on the patient’s condition, renal function and local treatment guidelines. Patients should follow the prescriber’s instructions exactly.

Nitrofurantoin is classified as pregnancy category B, indicating it may be used when the potential benefit justifies the potential risk. It is excreted in breast milk in small amounts; breastfeeding mothers should consult their healthcare provider.

To order Nifuretten, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nitrofurantoin offers targeted activity against common urinary pathogens and is concentrated in urine, reducing systemic exposure. Compared with trimethoprim‑sulfamethoxazole, it has a lower risk of resistance in some regions but may be contraindicated in patients with reduced renal function.

Store Nifuretten at ambient temperature, below 25 °C, in its original packaging to protect from moisture. Keep the product out of reach of children and avoid exposure to direct sunlight.

Nifuretten is taken orally, usually with food or a full glass of water to improve absorption and reduce gastrointestinal irritation. The tablet should be swallowed whole and not crushed or chewed.

Serious adverse reactions include pulmonary toxicity, hepatotoxicity, hemolytic anemia (especially in G6PD‑deficient patients), and severe skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience respiratory difficulty, jaundice, dark urine or rash.

Nifuretten should be avoided in patients with severe renal impairment (creatinine clearance < 30 mL/min), known hypersensitivity to nitrofurantoin, or G6PD deficiency due to the risk of hemolysis. It is also contraindicated in late pregnancy (≥ 38 weeks).

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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