Product image of Night Nurse (Dextromethorphan Hydrobromide, Promethazine Hydrochloride, Paracetamol) supplied by GNH India

Night Nurse

Active Ingredient:
Dextromethorphan Hydrobromide, Promethazine Hydrochloride, Paracetamol
Origin:
EU

Night Nurse (Dextromethorphan Hydrobromide, Promethazine Hydrochloride, Paracetamol)

Dextromethorphan Hydrobromide, the active ingredient in Night Nurse, is a combination antitussive, antihistamine and analgesic presented as an oral solution for oral use. It treats cough, nasal congestion, fever and related night‑time symptoms in adults and children.

GNH India supplies Night Nurse as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Haleon Uk Trading Limited

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Indications & Clinical Uses

Night Nurse, a combination antitussive, antihistamine and analgesic, provides symptomatic relief for common cold and flu presentations.

  • Cough: suppresses the cough reflex to improve sleep and comfort.
  • Runny nose: reduces nasal discharge through antihistamine action.
  • Sore throat: eases throat irritation and pain.
  • Fever: lowers elevated body temperature.
  • Night‑time symptom relief: combines sedative and analgesic effects to help patients rest.

How It Works

  • Dextromethorphan acts as a sigma‑1 receptor agonist and NMDA receptor antagonist, dampening the cough centre in the brain. Promethazine blocks H1 histamine receptors, providing antihistamine and sedative effects that lessen nasal congestion and promote sleep. Paracetamol inhibits central cyclooxygenase enzymes, producing analgesic and antipyretic actions that reduce pain and fever.

Side Effects

Night Nurse may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Drowsiness: increased sleepiness, especially at night.
  • Dry mouth: reduced salivation leading to throat discomfort.
  • Dizziness: light‑headed sensation after dosing.
  • Nausea: mild stomach upset.

Serious or Rare Side Effects

  • Allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Respiratory depression: slowed breathing, particularly when combined with other CNS depressants.

Precautions & Warnings

Before using Night Nurse, consider the following safety points.

  • Follow label instructions: adhere to the recommended dose and interval.
  • Avoid alcohol: may intensify drowsiness and respiratory effects.
  • Do not operate machinery: sedation can impair alertness.
  • Use with caution in liver disease: paracetamol is metabolised hepatically.
  • Avoid in children under 6 years: safety not established for this age group.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Night Nurse can interact with other medicines; awareness of the level of interaction is important.

Major Interactions (Avoid)

  • Alcohol: enhances central nervous system depression.
  • MAO inhibitors: risk of serotonin syndrome with dextromethorphan.
  • Other CNS depressants (e.g., benzodiazepines, opioids): may cause excessive sedation.
  • Additional paracetamol‑containing products: increases risk of hepatotoxicity.

Moderate Interactions (Monitor Closely)

  • Antihistamines: additive sedative effect.
  • Anticholinergic drugs: may worsen dry mouth.
  • CYP2D6 inhibitors (e.g., fluoxetine, quinidine): raise dextromethorphan plasma levels.

Frequently Asked Questions

Night Nurse is an over‑the‑counter oral solution that combines dextromethorphan, promethazine and paracetamol to relieve common cold and flu symptoms such as cough, nasal congestion, sore throat, fever and night‑time discomfort, helping patients achieve better rest.

Dextromethorphan suppresses the cough centre in the brain, promethazine blocks histamine receptors to reduce nasal congestion and provide sedation, and paracetamol inhibits central cyclooxygenase enzymes to lower pain and fever. The three actions complement each other for comprehensive symptom control.

The appropriate dose of Night Nurse is determined by the prescribing healthcare professional or according to the product label. Patients should follow the specific instructions provided on the packaging or by their clinician and should not exceed the recommended amount.

Safety of Night Nurse in pregnancy or while breastfeeding has not been definitively established. Women who are pregnant, planning to become pregnant, or nursing should consult their physician before using the product to weigh potential benefits against possible risks.

To order Night Nurse, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑ingredient OTC products, Night Nurse offers a three‑component formulation that simultaneously targets cough, congestion and fever. This broader symptom coverage can reduce the need for multiple separate medicines, but patients should consider individual ingredient tolerability and any specific contraindications.

Night Nurse should be stored at ambient temperature, below 25 °C, in its original container to protect it from moisture and light. Keep the bottle tightly closed and out of reach of children.

Night Nurse is taken orally as a measured liquid dose, usually with a calibrated dosing spoon or syringe provided with the product. The dose is administered at the intervals recommended on the label or by a healthcare professional.

Serious risks include severe allergic reactions such as rash, swelling or anaphylaxis, rare skin disorders like Stevens‑Johnson syndrome, and respiratory depression when combined with other central nervous system depressants. Immediate medical attention is required if any of these symptoms appear.

Night Nurse should be avoided by individuals with known hypersensitivity to any of its ingredients, children under six years of age, patients with severe liver impairment, and those taking monoamine oxidase inhibitors or other drugs that may cause dangerous interactions. Consultation with a healthcare provider is essential before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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