Product image of Nilogrin (Nicergoline) supplied by GNH India

Nilogrin

Active Ingredient:
Nicergoline
Origin:
EU

Nilogrin (Nicergoline)

Nicergoline, the active ingredient in Nilogrin, is an ergot alkaloid presented as an unknown/unknown for oral use. It is used to improve cerebral blood flow in adults with cerebrovascular insufficiency.
GNH India supplies Nilogrin as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Adamed Pharma S.A.

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Indications & Clinical Uses

Nicergoline acts on the cerebrovascular system to enhance cerebral perfusion and is employed in several recognised conditions.

  • Cerebral vascular insufficiency: improves blood flow and reduces related symptoms.
  • Age‑related cognitive decline: supports mental function in older adults.
  • Vascular dementia: may help stabilise cognition in dementia of vascular origin.

How It Works

  • Nicergoline increases cerebral blood flow by antagonising alpha‑adrenergic receptors, leading to vasodilation of cerebral vessels, and by inhibiting platelet aggregation, which together enhance oxygen and nutrient delivery to brain tissue.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Dizziness: sensation of light‑headedness, especially on standing.
  • Headache: transient cranial pain.
  • Gastro‑intestinal discomfort: abdominal pain or dyspepsia.
  • Hypotension: occasional drop in blood pressure.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Severe hypotension: marked blood pressure fall requiring medical attention.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.
  • Bleeding complications: due to platelet inhibition.
  • Allergic reactions: rash, itching, or anaphylaxis.
  • Cardiac arrhythmia: irregular heart rhythm.
  • Vasospasm: rare constriction of blood vessels.

Precautions & Warnings

When prescribing Nilogrin, consider the following precautions.

  • Renal impairment: monitor kidney function and adjust use if needed.
  • Hepatic disease: assess liver enzymes before initiation.
  • Bleeding disorders: avoid or use with caution because of antiplatelet effects.
  • Pregnancy and lactation: limit use to situations where benefits outweigh potential risks.
  • Concomitant ergot drugs: avoid combined use to prevent additive vasospasm.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Nilogrin may interact with several drug classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Other ergot derivatives: increased risk of vasospasm.
  • Potent CYP3A4 inhibitors (e.g., ketoconazole): may raise nicergoline plasma levels.
  • Anticoagulants (e.g., warfarin): heightened bleeding tendency.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: additive hypotensive effect.
  • Antiplatelet agents (e.g., aspirin, clopidogrel): monitor for bleeding.
  • SSRIs/SNRIs: potential for increased bleeding risk.

Frequently Asked Questions

Nilogrin contains nicergoline, which is indicated for conditions that involve reduced cerebral blood flow. It is commonly used to treat cerebral vascular insufficiency, age‑related cognitive decline, and vascular dementia, helping to improve brain perfusion and support mental function in affected adults.

Nicergoline works by blocking alpha‑adrenergic receptors, causing dilation of cerebral blood vessels, and by inhibiting platelet aggregation. These actions increase oxygen and nutrient delivery to the brain, thereby enhancing cerebral perfusion and supporting neurological function.

The prescribed dose of Nilogrin is determined by the treating physician based on the patient’s clinical condition, age, and response to therapy. Dosage may vary, and the prescriber will provide specific instructions tailored to each individual.

Safety data for nicergoline in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Nilogrin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with other vasodilators such as pentoxifylline, nicergoline uniquely combines alpha‑adrenergic antagonism with antiplatelet activity, offering both vascular dilation and reduced platelet aggregation. This dual mechanism can provide broader support for cerebral perfusion, though individual response varies and should be evaluated by a clinician.

Nilogrin should be stored at temperatures below 25 °C, in its original packaging, and protected from moisture. Keep the product away from direct sunlight and out of reach of children to maintain its stability and potency.

Nilogrin is taken orally, usually with a glass of water. It can be taken with or without food, but following the prescribing physician’s instructions regarding timing and any dietary considerations is important.

Serious risks include severe hypotension, hepatic dysfunction, significant bleeding due to platelet inhibition, allergic reactions such as rash or anaphylaxis, and rare cases of cardiac arrhythmia or vasospasm. Patients should seek immediate medical attention if any of these symptoms occur.

Nilogrin is contraindicated in patients with known hypersensitivity to nicergoline or other ergot derivatives, those with uncontrolled hypertension, active bleeding disorders, severe liver disease, or who are currently taking other ergot‑based medications. A healthcare professional should evaluate suitability before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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