Product image of Nilox Midi (Nitroxoline) supplied by GNH India

Nilox Midi

Active Ingredient:
Nitroxoline
Origin:
EU

Nilox Midi (Nitroxoline)

Nitroxoline, the active ingredient in Nilox Midi, is a quinoline antibacterial presented as an oral tablet for oral use. It treats urinary tract infections in adult patients.
GNH India supplies Nilox Midi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Cnp Pharma Gmbh

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Indications & Clinical Uses

Nitroxoline is used to manage infections of the urinary tract by targeting bacterial growth.

  • Uncomplicated urinary tract infection: reduces bacterial load and alleviates symptoms.
  • Complicated urinary tract infection: assists in clearing infection when anatomical or functional abnormalities are present.
  • Recurrent urinary tract infection: helps prevent further episodes by eradicating persistent pathogens.
  • Prophylaxis of urinary infections in susceptible patients: provides ongoing antimicrobial protection during high‑risk periods.

How It Works

  • Nitroxoline exerts its antibacterial effect by chelating divalent metal ions such as iron and magnesium, which are essential cofactors for bacterial enzymes. This chelation disrupts enzymatic activity and impairs bacterial metabolism in the urinary tract, leading to inhibition of bacterial growth and eventual cell death.

Side Effects

Nitroxoline may cause several adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea
  • Dyspepsia
  • Headache
  • Dizziness

Serious or Rare Side Effects

  • Hepatic dysfunction (elevated transaminases)
  • Severe allergic reactions, including anaphylaxis

Precautions & Warnings

Before prescribing Nitroxoline, clinicians should consider several safety factors.

  • Renal function: assess baseline kidney function and monitor during therapy.
  • Hepatic function: evaluate liver enzymes prior to initiation.
  • Allergy: avoid use in patients with known hypersensitivity to quinoline derivatives.
  • Pregnancy: prescribe only if the potential benefit justifies the potential risk to the fetus.
  • Drug interactions: review concomitant medications for possible interactions.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Nitroxoline can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Iron supplements: chelation reduces nitroxoline absorption.
  • Anticoagulants: may potentiate bleeding risk.
  • Probenecid: can increase nitroxoline plasma concentrations.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may increase risk of renal impairment.
  • Diuretics: monitor electrolyte balance and renal function.
  • Sulfonamides: additive irritation of the urinary tract may occur.

Frequently Asked Questions

Nilox Midi contains nitroxoline, an oral quinoline antibacterial indicated for the treatment of urinary tract infections in adults. It works by eliminating the bacteria that cause infection, helping to relieve symptoms such as dysuria, frequency, and urgency.

Nitroxoline chelates essential metal ions like iron and magnesium, which are cofactors for bacterial enzymes. By binding these ions, it disrupts enzymatic activity and bacterial metabolism in the urinary tract, leading to inhibition of bacterial growth and bacterial cell death.

The specific dose and treatment duration of Nilox Midi are determined by the prescribing healthcare professional based on the severity of the infection, patient age, renal function, and other clinical factors. Patients should follow the prescriber’s instructions exactly.

Safety data for nitroxoline in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and only under the guidance of a qualified healthcare provider.

To request Nilox Midi, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with other urinary antiseptics such as trimethoprim‑sulfamethoxazole, nitroxoline offers a distinct mechanism of metal‑ion chelation, which can be advantageous in infections caused by resistant organisms. Choice of therapy depends on local resistance patterns, patient tolerance, and clinician preference.

Nilox Midi should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and excessive heat. Keep the product out of reach of children and avoid exposing it to direct sunlight.

Nilox Midi is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless otherwise directed by a healthcare professional.

Serious risks, although rare, include hepatic dysfunction and severe allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience signs of liver injury (e.g., jaundice, dark urine) or symptoms of a severe allergic response (e.g., rash, swelling, difficulty breathing).

Nilox Midi should be avoided in individuals with a known hypersensitivity to nitroxoline or other quinoline derivatives. Caution is also advised for patients with significant renal or hepatic impairment, and it should be used only under medical supervision in pregnant or breastfeeding women.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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