Nimelid (Nimesulide)

Nimesulide selectively blocks the cyclooxygenase‑2 (COX‑2) enzyme, which reduces the production of prostaglandins responsible for pain, inflammation and fever. By targeting COX‑2 while sparing COX‑1, it aims to maintain efficacy with a lower risk of gastrointestinal irritation.

The appropriate dose of Nimelid is determined by the prescribing healthcare professional based on the patient’s condition, age, renal and hepatic function, and other individual factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

The safety of nimesulide in pregnancy and lactation has not been established. It is generally avoided in pregnant or nursing women unless the potential benefit outweighs the potential risk, and only under close medical supervision.

To request Nimelid, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nimelid (nimesulide) is a COX‑2 selective NSAID, offering analgesic and anti‑inflammatory benefits similar to ibuprofen or diclofenac but with a theoretically lower risk of gastric irritation. However, it carries a distinct risk of liver toxicity, which requires periodic monitoring.

Nimelid tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original container, protect from moisture and direct sunlight, and ensure they are out of reach of children.

Nimelid is taken orally, usually with a full glass of water. It can be taken with or without food, but patients who experience stomach upset may benefit from taking it with meals. Swallow the tablet whole; do not crush or chew.

The most serious risks include severe liver injury, potentially leading to hepatitis or liver failure, and rare but life‑threatening skin reactions such as Stevens‑Johnson syndrome. Prompt medical attention is required if signs of liver dysfunction or severe skin rash appear.

Nimelid should be avoided in patients with known hypersensitivity to nimesulide or other NSAIDs, those with active or severe liver disease, severe renal impairment, and individuals who have experienced serious skin reactions to NSAIDs. It is also contraindicated in the third trimester of pregnancy.