Product image of Nimesulid Arena (Nimesulide) supplied by GNH India

Nimesulid Arena

Active Ingredient:
Nimesulide
Origin:
EU

Nimesulid Arena (Nimesulide)

Nimesulide, the active ingredient in Nimesulid Arena, is a nonsteroidal anti-inflammatory drug presented as an oral tablet for systemic use. It is prescribed to relieve pain, reduce inflammation, and lower fever in adult patients with conditions such as osteoarthritis, dysmenorrhea, and acute musculoskeletal discomfort.

GNH India supplies Nimesulid Arena as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets.

Manufacturer / TM Owner

Arena Group S.A

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Nimesulide is used to manage pain and inflammatory conditions by targeting prostaglandin‑mediated pathways.

  • Acute pain: provides rapid analgesia to alleviate discomfort.
  • Chronic osteoarthritis: reduces joint inflammation and improves mobility.
  • Dysmenorrhea: lessens menstrual cramps and associated pain.
  • Fever: lowers elevated body temperature in febrile states.
  • Inflammatory disorders: diminishes swelling and redness in soft‑tissue inflammation.

How It Works

  • Nimesulide selectively inhibits cyclooxygenase‑2 (COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins. By reducing prostaglandin synthesis, it attenuates inflammation, pain signaling, and fever generation while sparing COX‑1 activity, which helps maintain gastric mucosal protection. The preferential COX‑2 inhibition contributes to its analgesic and antipyretic properties, making it effective for a range of musculoskeletal and inflammatory conditions.

Side Effects

Nimesulide may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
  • Headache.
  • Dizziness.
  • Skin rash.

Serious or Rare Side Effects

  • Hepatotoxicity: severe liver injury.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Gastrointestinal ulceration or bleeding.

Precautions & Warnings

When prescribing Nimesulide, clinicians should observe several safety measures to minimize risk.

  • Assess liver function: obtain baseline hepatic enzymes and monitor periodically.
  • Avoid in patients with known hypersensitivity to sulfonamides or other NSAIDs.
  • Use the lowest effective dose for the shortest duration to limit gastrointestinal risk.
  • Caution in individuals with existing peptic ulcer disease or bleeding disorders.
  • Monitor renal function: especially in elderly or dehydrated patients.
  • Store at ambient temperature below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Nimesulide can interact with several medicines, requiring careful assessment before co‑administration.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Lithium: elevated lithium serum levels.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents (ACE inhibitors, diuretics): possible reduction in antihypertensive effect.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency.
  • Methotrexate: reduced clearance leading to toxicity.

Frequently Asked Questions

Nimesulid Arena contains the NSAID nimesulide and is prescribed to relieve moderate to severe pain, reduce inflammation, and lower fever. It is commonly used in conditions such as osteoarthritis, dysmenorrhea, and acute musculoskeletal pain.

Nimesulide works by selectively inhibiting the cyclooxygenase‑2 (COX‑2) enzyme, which reduces the synthesis of prostaglandins that mediate pain, inflammation, and fever. This preferential COX‑2 inhibition provides analgesic and antipyretic effects while sparing COX‑1 activity.

The appropriate dose of Nimesulid Arena is determined by the prescribing healthcare professional based on the patient’s condition, severity of symptoms, age, renal and hepatic function, and any concomitant medications. No fixed regimen is provided here.

Nimesulide is classified as pregnancy category X, indicating it is contraindicated in pregnancy because of potential fetal harm. It is also not recommended during breastfeeding, as it may pass into breast milk and affect the infant.

To order Nimesulid Arena, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both nimesulide and ibuprofen are NSAIDs that inhibit COX enzymes, but nimesulide has a higher selectivity for COX‑2, which may result in a different safety profile, particularly regarding gastrointestinal tolerance. Clinical choice depends on efficacy, patient risk factors, and physician preference.

Nimesulid Arena tablets should be stored at ambient temperature below 25 °C, in their original packaging, protected from moisture and direct light. Do not store in a refrigerator or freezer.

Nimesulid Arena is taken orally with a full glass of water. It is usually administered with food or a milky drink to lessen possible gastrointestinal irritation, unless the prescriber advises otherwise.

The most serious risks include hepatotoxicity (potential liver injury), severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, and gastrointestinal ulceration or bleeding, which may be life‑threatening.

Nimesulid Arena should be avoided in patients with known hypersensitivity to nimesulide or other sulfonamide drugs, active peptic ulcer disease, severe hepatic impairment, pregnancy, breastfeeding, and in those taking other NSAIDs or anticoagulants without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Nimesulide

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT