Product image of Nimesulid Leram (Nimesulide) supplied by GNH India

Nimesulid Leram

Active Ingredient:
Nimesulide
Origin:
EU

Nimesulid Leram (Nimesulide)

Nimesulide, the active ingredient in Nimesulid Leram, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for use. It is employed to relieve mild to moderate pain, reduce inflammation, and lower fever in adult patients. It is indicated for conditions such as osteoarthritis, dysmenorrhea, and other inflammatory disorders.

GNH India supplies Nimesulid Leram as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑supported distribution to meet global demand.

Manufacturer / TM Owner

Leram Pharmaceuticals S.R.O.

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Indications & Clinical Uses

Nimesulide acts on inflammatory pathways to provide analgesic, antipyretic, and anti‑inflammatory effects.

  • Mild to moderate pain: alleviates acute or chronic pain by reducing prostaglandin‑mediated sensitization.
  • Inflammation: decreases swelling and tissue irritation in musculoskeletal and soft‑tissue conditions.
  • Fever: lowers elevated body temperature associated with inflammatory or infectious processes.
  • Osteoarthritis: improves joint comfort and function by limiting inflammatory mediators in degenerative joints.
  • Dysmenorrhea: reduces menstrual cramps through inhibition of uterine prostaglandin synthesis.

How It Works

  • Nimesulide selectively inhibits the cyclooxygenase‑2 (COX‑2) enzyme, which curtails the conversion of arachidonic acid to prostaglandins. By lowering prostaglandin synthesis, it diminishes inflammation, pain signaling, and fever generation while sparing COX‑1 activity to a greater extent than non‑selective NSAIDs.

Side Effects

Nimesulide may cause a range of adverse reactions, from mild discomfort to serious organ toxicity.

Common Side Effects

  • Gastrointestinal discomfort: abdominal pain, dyspepsia, or heartburn.
  • Nausea and vomiting: feeling sick or expelling stomach contents.
  • Headache: mild to moderate cranial pain.
  • Dizziness: transient light‑headedness or vertigo.

Serious or Rare Side Effects

  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Gastrointestinal ulceration or bleeding.
  • Acute renal failure or significant decline in kidney function.

Precautions & Warnings

Before prescribing Nimesulid Leram, clinicians should consider several safety measures.

  • Hypersensitivity: discontinue if allergic reactions such as rash, itching, or swelling occur.
  • Peptic ulcer disease: avoid in patients with active ulcers or a history of gastrointestinal bleeding.
  • Liver function: monitor hepatic enzymes during prolonged therapy.
  • Concomitant NSAIDs/anticoagulants: use with caution as bleeding risk may increase.
  • Elderly patients: start at the lowest effective dose and monitor for adverse events.
  • Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture and light.

Avoid Interactions

Nimesulid Leram can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity.
  • Lithium: elevated lithium serum levels and potential toxicity.

Moderate Interactions (Monitor Closely)

  • Methotrexate: possible increase in methotrexate toxicity.
  • SSRIs or SNRIs: additive risk of bleeding.

Frequently Asked Questions

Nimesulid Leram contains the NSAID nimesulide and is prescribed to treat mild to moderate pain, reduce inflammation, and lower fever. It is commonly used in conditions such as osteoarthritis, dysmenorrhea, and other inflammatory disorders where prostaglandin‑mediated symptoms are present.

Nimesulide works by selectively inhibiting the cyclooxygenase‑2 (COX‑2) enzyme, which reduces the synthesis of prostaglandins that drive pain, inflammation, and fever. This targeted action helps control symptoms while sparing COX‑1 activity, which is important for protecting the stomach lining.

The appropriate dose of Nimesulid Leram is determined by the prescribing healthcare professional based on the patient’s condition, age, and overall health. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for nimesulide in pregnancy and lactation are limited, and the product is generally not recommended for use in pregnant or breastfeeding women unless clearly justified by a physician. The prescriber will weigh potential benefits against possible risks.

To request Nimesulid Leram, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nimesulide is a COX‑2 selective NSAID, which may offer a lower risk of gastrointestinal irritation compared with non‑selective NSAIDs such as ibuprofen or diclofenac. However, it carries its own safety profile, including potential liver effects, and should be chosen based on individual patient risk factors and therapeutic goals.

Store Nimesulid Leram tablets at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability.

Nimesulid Leram is taken orally, usually with a full glass of water. The tablet should be swallowed whole and not chewed or crushed, unless the prescriber provides specific instructions for a different administration method.

Serious adverse events include hepatotoxicity (liver injury), severe skin reactions such as Stevens‑Johnson syndrome, gastrointestinal ulceration or bleeding, and acute renal failure. Patients should be monitored for signs of liver dysfunction, skin changes, or gastrointestinal symptoms, and seek medical attention promptly if they occur.

Nimesulid Leram should be avoided in individuals with known hypersensitivity to nimesulide or other NSAIDs, active peptic ulcer disease, severe liver impairment, or those taking anticoagulants without close monitoring. It is also contraindicated in patients with a history of severe skin reactions to NSAIDs.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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