Product image of Nimesulida Pentafarma (Nimesulide) supplied by GNH India

Nimesulida Pentafarma

Active Ingredient:
Nimesulide
Origin:
EU

Nimesulida Pentafarma (Nimesulide)

Nimesulide, the active ingredient in Nimesulida Pentafarma, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for systemic use. It is used to relieve mild to moderate pain, reduce fever and manage inflammatory conditions such as osteoarthritis and dysmenorrhea.

GNH India supplies Nimesulida Pentafarma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pentafarma - Sociedade Tecnico-Medicinal S.A.

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Indications & Clinical Uses

Nimesulida Pentafarma, an NSAID, acts on inflammatory pathways to alleviate several common conditions.

  • Mild to moderate pain: provides analgesic relief in acute or chronic pain states.
  • Fever: reduces elevated body temperature associated with infectious or inflammatory processes.
  • Osteoarthritis and musculoskeletal pain: decreases joint inflammation and improves mobility.
  • Dysmenorrhea: alleviates menstrual cramps and associated discomfort.

How It Works

  • Nimesulide selectively inhibits cyclooxygenase‑2 (COX‑2), which reduces the synthesis of prostaglandins responsible for pain, fever and inflammation. By sparing COX‑1 activity, it aims to limit gastrointestinal side effects while maintaining anti‑inflammatory efficacy.

Side Effects

Nimesulida Pentafarma may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Gastrointestinal discomfort: mild nausea, dyspepsia or abdominal pain.
  • Headache: transient tension‑type headache.
  • Dizziness: occasional light‑headedness.
  • Skin rash: mild erythema or pruritus.
  • Elevated liver enzymes: transient increase in transaminases.

Serious or Rare Side Effects

  • Hepatotoxicity: severe liver injury requiring monitoring.
  • Gastrointestinal ulcer or bleeding: risk of serious GI complications.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Renal impairment: acute kidney injury, especially in at‑risk patients.
  • Anaphylaxis: rare but potentially life‑threatening allergic response.

Precautions & Warnings

Before prescribing Nimesulida Pentafarma, clinicians should consider several safety measures.

  • Assess liver function: obtain baseline transaminases and monitor periodically.
  • Evaluate gastrointestinal risk: avoid in patients with active ulcers or a history of GI bleeding.
  • Review renal status: adjust use in patients with impaired kidney function.
  • Caution with cardiovascular disease: NSAIDs may increase thrombotic risk.
  • Avoid in known hypersensitivity to nimesulide or other NSAIDs.
  • Store at ambient temperature: keep below 25 °C in the original container, protected from moisture and light.

Avoid Interactions

Nimesulida Pentafarma can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Lithium: elevated lithium levels, risk of toxicity.
  • Methotrexate: reduced clearance, potential toxicity.
  • Cyclosporine: enhanced nephrotoxicity.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: possible reduction in blood pressure control.
  • Diuretics: risk of renal function decline.
  • SSRIs or SNRIs: heightened bleeding tendency.
  • Corticosteroids: synergistic GI ulcer risk.
  • Oral hypoglycemics: potential alteration of glucose control.

Frequently Asked Questions

Nimesulida Pentafarma contains nimesulide, an NSAID indicated for mild to moderate pain, fever, osteoarthritis, musculoskeletal inflammation and dysmenorrhea. It provides analgesic, antipyretic and anti‑inflammatory effects in these recognized clinical situations.

Nimesulide selectively blocks the cyclooxygenase‑2 (COX‑2) enzyme, which reduces the production of prostaglandins that mediate pain, fever and inflammation. By targeting COX‑2, it aims to preserve COX‑1 activity and limit gastrointestinal side effects while delivering anti‑inflammatory benefits.

The dosage of Nimesulida Pentafarma is determined by the prescribing clinician based on the patient’s condition, age, weight and renal or hepatic function. Healthcare professionals set the appropriate regimen according to local prescribing guidelines.

Safety data for nimesulide in pregnancy and lactation are limited, and the drug is generally avoided unless the potential benefit outweighs the risk. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To request Nimesulida Pentafarma, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nimesulide is a COX‑2 selective NSAID, offering analgesic and anti‑inflammatory effects similar to ibuprofen or diclofenac but with a potentially lower risk of gastrointestinal irritation. However, it carries a distinct hepatic safety profile, so liver function monitoring is more emphasized compared with non‑selective NSAIDs.

Store Nimesulida Pentafarma at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, heat and direct sunlight to maintain stability.

Nimesulida Pentafarma is taken orally, usually with a full glass of water. It may be taken with or without food, but patients with gastrointestinal sensitivity often benefit from taking it with meals to reduce stomach discomfort.

Serious risks include hepatotoxicity, severe gastrointestinal bleeding or ulceration, renal impairment, and rare but life‑threatening skin reactions such as Stevens‑Johnson syndrome. Patients should be monitored for signs of liver dysfunction, abdominal pain, or skin changes.

Nimesulida Pentafarma should be avoided in individuals with known hypersensitivity to nimesulide or other NSAIDs, active peptic ulcer disease, severe hepatic or renal impairment, and in patients taking anticoagulants or other NSAIDs without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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