Product image of Nimodipina Altan (Nimodipine) supplied by GNH India

Nimodipina Altan

Active Ingredient:
Nimodipine
Origin:
EU

Nimodipina Altan (Nimodipine)

Nimodipine, the active ingredient in Nimodipina Altan, is a calcium channel blocker presented as an injection solution for intravenous use. It is employed to prevent cerebral vasospasm following subarachnoid hemorrhage, helping to reduce the risk of delayed cerebral ischemia in affected patients.

GNH India supplies Nimodipina Altan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, clinics and procurement teams worldwide, ensuring consistent quality and regulatory compliance across global markets. The company adheres to stringent Good Distribution Practice standards and provides dedicated technical support for seamless integration into clinical workflows.

Manufacturer / TM Owner

Altan Pharma Ltd

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Indications & Clinical Uses

Nimodipine is used to address cerebral vasospasm, a complication of subarachnoid hemorrhage, by improving cerebral blood flow.

  • Subarachnoid hemorrhage: prophylaxis of cerebral vasospasm to lower risk of delayed ischemic neurologic deficits.
  • Aneurysmal SAH: reduction of incidence of secondary cerebral infarction through sustained vasodilation.
  • Post‑hemorrhagic neurological care: support of cerebral perfusion during the critical 14‑day risk period.

How It Works

  • Nimodipine selectively blocks L‑type calcium channels on vascular smooth muscle, particularly within cerebral arteries. By inhibiting calcium influx, it induces relaxation of these vessels, producing vasodilation that enhances cerebral blood flow. This targeted action counteracts the constrictive response that follows subarachnoid hemorrhage, thereby helping to prevent ischemic complications. The effect is dose‑dependent and persists for several hours after infusion, providing a therapeutic window during the period of highest vasospasm risk.

Side Effects

Nimodipine may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Hypotension: transient drop in blood pressure, especially with rapid infusion.
  • Headache: mild to moderate intensity, often resolving with continued therapy.
  • Nausea: occasional gastrointestinal upset without vomiting.
  • Flushing: warm sensation and reddening of the skin.

Serious or Rare Side Effects

  • Severe hypotension: marked blood pressure decline requiring medical intervention.
  • Myocardial infarction: rare occurrence of cardiac ischemia.
  • Hepatic dysfunction: elevated liver enzymes indicating liver injury.
  • Anaphylactic reaction: acute allergic response with rash, bronchospasm or shock.

Precautions & Warnings

When using Nimodipine, clinicians should observe specific precautions to minimize risk and ensure safe administration.

  • Renal impairment: monitor renal function and adjust infusion rate if necessary.
  • Hepatic impairment: use with caution; liver dysfunction may increase drug exposure.
  • Concomitant vasodilators: assess for additive hypotensive effects.
  • Pregnancy: avoid unless the potential benefit justifies the potential risk to the fetus.
  • Elderly patients: observe closely for exaggerated hypotension and dizziness.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Nimodipine can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Other calcium channel blockers: additive vasodilatory effect may cause severe hypotension.
  • Beta‑blockers: combined use can lead to profound bradycardia and hypotension.
  • Nitrates: concurrent administration may result in excessive vasodilation and low blood pressure.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): increase plasma concentrations of Nimodipine.
  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): reduce Nimodipine levels, potentially diminishing therapeutic effect.

Frequently Asked Questions

Nimodipina Altan contains the calcium channel blocker nimodipine and is indicated for the prophylaxis of cerebral vasospasm following subarachnoid hemorrhage. By preventing vessel constriction, it helps reduce the risk of delayed cerebral ischemia in patients who have experienced this type of brain bleed.

Nimodipine selectively antagonizes L‑type calcium channels on the smooth muscle of cerebral arteries. This inhibition reduces calcium entry, causing the vessels to relax and dilate, which improves cerebral blood flow and counteracts the vasospastic response that can follow a subarachnoid hemorrhage.

The specific dose and infusion rate of Nimodipina Altan are determined by the treating physician based on the patient’s clinical condition, weight, and renal or hepatic function. Prescribers follow established guidelines for intravenous administration in the context of subarachnoid hemorrhage.

The safety of Nimodipina Altan during pregnancy or lactation has not been established. It should be used only if the potential therapeutic benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the Nimodipina Altan product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and any necessary import documentation.

Nimodipine is the most widely studied calcium channel blocker for vasospasm prophylaxis and is preferred because of its selective cerebral vasodilatory effect. Other agents, such as magnesium sulfate or endothelin antagonists, have been investigated but lack the robust evidence base and regulatory approval that nimodipine holds for this indication.

Nimodipina Altan must be stored at 2‑8 °C in a refrigerator. It should be kept in its original packaging, protected from light, and must not be frozen or shaken. Before use, inspect the solution for particulate matter or discoloration and discard if any abnormalities are observed.

The product is supplied as an injectable solution for intravenous infusion. Administration is performed by qualified healthcare personnel in a controlled setting, typically using a calibrated infusion pump to deliver the prescribed rate over the recommended duration. Continuous monitoring of blood pressure and cardiac status is advised during the infusion.

Serious adverse events include severe hypotension, myocardial infarction, hepatic dysfunction, and anaphylactic reactions. Patients should be closely monitored for abrupt drops in blood pressure, chest pain, signs of liver injury (elevated enzymes), or allergic manifestations such as rash, bronchospasm, or shock, and appropriate medical intervention should be initiated promptly.

Nimodipina Altan is contraindicated in patients with known hypersensitivity to nimodipine or any component of the formulation. Caution is also advised for individuals with severe hypotension, uncontrolled heart failure, or those receiving other potent vasodilators where additive effects could be dangerous. The prescriber must evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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