Product image of Nimodipina Doc Generici (Nimodipine) supplied by GNH India

Nimodipina Doc Generici

Active Ingredient:
Nimodipine
Origin:
EU

Nimodipina Doc Generici (Nimodipine)

Nimodipine, the active ingredient in Nimodipina Doc Generici, is a calcium channel blocker presented as an oral tablet for oral use. It is indicated for the prevention of cerebral vasospasm after subarachnoid hemorrhage in affected patients.

GNH India supplies Nimodipina Doc Generici as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU GMP standards and provides reliable logistics for regulated markets. Products are shipped with full documentation, including certificates of analysis and import permits where required.

Manufacturer / TM Owner

Doc Generici S.R.L.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Nimodipine is a calcium channel blocker used to manage cerebrovascular complications.
  • Prevention of cerebral vasospasm after subarachnoid hemorrhage: reduces delayed ischemic neurological deficits by dilating cerebral arteries.
  • Adjunctive therapy in aneurysmal subarachnoid hemorrhage: helps maintain cerebral blood flow during the acute phase.
  • Management of cerebral vasospasm in neurocritical care settings: supports neurological recovery by improving perfusion.

How It Works

  • Nimodipine selectively blocks L‑type voltage‑gated calcium channels in vascular smooth muscle, especially in cerebral arteries. By inhibiting calcium influx, it induces relaxation of the arterial wall, leading to vasodilation and increased cerebral blood flow, which helps prevent the narrowing of vessels that can follow subarachnoid hemorrhage.

Side Effects

Nimodipine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness.
  • Hypotension: especially in volume‑depleted patients.
  • Nausea or vomiting: gastrointestinal discomfort.
  • Dizziness or vertigo: related to blood pressure changes.
  • Tachycardia: increased heart rate.

Serious or Rare Side Effects

  • Severe hypotension: may lead to syncope.
  • Bradycardia: markedly slow heart rate.
  • Allergic reactions: rash, pruritus, or angioedema.
  • Hepatic enzyme elevation: abnormal liver function tests.
  • Myocardial infarction: rare cardiac events.
  • Seizures: extremely uncommon but reported.

Precautions & Warnings

  • Before initiating therapy, clinicians should evaluate patient-specific factors and monitor for potential complications.
  • Monitor blood pressure: watch for hypotension, especially in dehydrated individuals.
  • Avoid abrupt discontinuation: taper if long‑term therapy is planned.
  • Use with caution in hepatic impairment: dose adjustment may be required.
  • Avoid concurrent strong CYP3A4 inhibitors: may increase plasma concentrations.
  • Pregnancy: risk unknown; weigh benefits against potential hazards.
  • Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture.

Avoid Interactions

Nimodipine can interact with several drug classes, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir): may raise nimodipine levels and precipitate severe hypotension.
  • Concurrent use with other potent vasodilators: risk of additive blood pressure lowering.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce therapeutic effect.
  • Antihypertensive agents: additive hypotensive effect requires dose adjustment.
  • Diuretics: can exacerbate volume depletion and hypotension.
  • NSAIDs: may affect renal perfusion when combined with vasodilation.
  • Beta‑blockers: monitor heart rate and blood pressure closely.

Frequently Asked Questions

Nimodipina Doc Generici contains nimodipine, which is prescribed to prevent cerebral vasospasm following a subarachnoid hemorrhage. By keeping the brain’s blood vessels dilated, the medication helps reduce the risk of delayed ischemic neurological deficits in patients who have experienced this type of bleeding.

Nimodipine blocks L‑type calcium channels on the smooth muscle of cerebral arteries. This inhibition reduces calcium entry into the cells, causing the vessels to relax and widen. The resulting vasodilation improves cerebral blood flow and counters the narrowing that can occur after a subarachnoid hemorrhage.

The dosage of Nimodipina Doc Generici is determined by the prescribing clinician based on the patient’s condition, age, weight, and renal or hepatic function. Healthcare professionals follow established guidelines and adjust the regimen as needed; patients should not alter the dose without medical advice.

Safety data for nimodipine in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. The potential benefits must be weighed against possible risks, and the medication should only be used if the prescriber deems it essential for the mother’s health.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nimodipine is a selective L‑type calcium channel antagonist with a high affinity for cerebral vessels, making it especially effective for preventing vasospasm after subarachnoid hemorrhage. Other vasodilators, such as nitroglycerin or hydralazine, act systemically and lack the same degree of cerebral selectivity, which can limit their usefulness in this specific neurovascular indication.

The tablets should be stored at ambient temperature, preferably below 25 °C, in their original container to protect them from moisture and light. Keep the product out of reach of children and avoid storing it in humid environments such as bathrooms.

Nimodipina Doc Generici is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless the prescriber provides specific instructions. Administration timing (e.g., with or without food) follows the guidance of the treating physician.

The most critical adverse events include severe hypotension, which can lead to fainting or shock, and rare cardiac complications such as bradycardia or myocardial infarction. Allergic reactions, including rash or angioedema, and significant liver enzyme elevations are also serious concerns that require immediate medical attention.

Patients with known hypersensitivity to nimodipine or any component of the tablet should avoid the product. It is also contraindicated in individuals with severe hypotension, uncontrolled heart failure, or those taking strong CYP3A4 inhibitors without appropriate dose adjustments. Clinicians must assess each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.