Product image of Nimodipine Altan (Nimodipine) supplied by GNH India

Nimodipine Altan

Active Ingredient:
Nimodipine
Origin:
EU

Nimodipine Altan (Nimodipine)

Nimodipine, the active ingredient in Nimodipine Altan, is a calcium channel blocker (dihydropyridine) presented as an intravenous solution for hospital use. It is employed to prevent cerebral vasospasm in patients who have suffered a subarachnoid hemorrhage.

GNH India supplies Nimodipine Altan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Altan Pharma Ltd

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Indications & Clinical Uses

Nimodipine is used in the management of cerebrovascular complications, particularly to reduce vasospasm after subarachnoid hemorrhage.

  • Subarachnoid hemorrhage (post‑aneurysmal): Prevention of cerebral vasospasm, helping maintain adequate cerebral blood flow.
  • Delayed cerebral ischemia after SAH: Reduction of risk by improving microvascular perfusion.
  • Neurocritical care patients at risk of vasospasm: Maintenance of cerebral perfusion to limit secondary brain injury.

How It Works

  • Nimodipine antagonizes L‑type calcium channels on vascular smooth muscle, especially in cerebral arteries. By inhibiting calcium influx, it induces selective vasodilation of cerebral vessels, decreasing arterial tone and mitigating the development of vasospasm that can follow subarachnoid hemorrhage, thereby supporting cerebral blood flow.

Side Effects

Nimodipine may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and reddening of the skin.
  • Hypotension: low blood pressure, especially when administered rapidly.
  • Nausea: occasional gastrointestinal upset.
  • Dizziness: sensation of light‑headedness.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical intervention.
  • Cardiac arrhythmias: irregular heart rhythms, particularly in patients with pre‑existing cardiac disease.
  • Allergic reactions: rash, itching, or anaphylaxis in rare cases.

Precautions & Warnings

When using Nimodipine, clinicians should consider several safety measures.

  • Cardiovascular monitoring: observe blood pressure and heart rate during infusion.
  • Concomitant vasodilators: avoid combining with other potent vasodilators without supervision.
  • Hepatic impairment: dose adjustment may be required in patients with liver dysfunction.
  • Pregnancy and lactation: use only if the potential benefit justifies the potential risk to the fetus or infant.
  • Store at ambient temperature: keep below 25°C, in the original packaging, protected from moisture and light.

Avoid Interactions

Nimodipine can interact with other medicines, influencing its safety and efficacy.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase plasma levels and risk of toxicity.
  • Concurrent use with other potent vasodilators: can cause profound hypotension.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce therapeutic effect.
  • Beta‑blockers: may mask tachycardia caused by hypotension.
  • Diuretics: can enhance blood‑pressure‑lowering effect, requiring closer monitoring.

Frequently Asked Questions

Nimodipine Altan is indicated for the prevention of cerebral vasospasm in patients who have experienced a subarachnoid hemorrhage. By reducing the risk of vessel narrowing, it helps maintain adequate blood flow to the brain during the critical post‑hemorrhage period.

Nimodipine blocks L‑type calcium channels on the smooth muscle of cerebral arteries. This inhibition reduces calcium‑mediated contraction, leading to selective dilation of brain vessels and a decrease in the likelihood and severity of vasospasm after hemorrhagic events.

The dosage of Nimodipine Altan is determined by the prescribing clinician based on the patient’s condition, weight, and clinical response. The prescribing information provides guidance, but the exact regimen must be individualized and documented by a qualified healthcare professional.

Safety data for Nimodipine in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Nimodipine is a dihydropyridine calcium‑channel blocker that offers selective cerebral vasodilation, whereas other agents such as clazosentan target endothelin receptors. Nimodipine’s advantage lies in its well‑established efficacy for SAH‑related vasospasm and a relatively favorable safety profile when used under controlled conditions.

Store Nimodipine Altan at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct light, and ensure that the vial is sealed until use to maintain sterility.

Nimodipine Altan is supplied for intravenous infusion. The medication is administered by a qualified healthcare professional in a hospital or clinical setting, following aseptic technique and the dosing instructions provided by the prescriber.

The most serious risks include severe hypotension, which can lead to syncope or organ hypoperfusion, and rare but potentially life‑threatening allergic reactions such as anaphylaxis. Continuous monitoring of blood pressure and signs of hypersensitivity is essential during treatment.

Patients with known hypersensitivity to nimodipine or any component of the formulation should avoid its use. Caution is also advised for individuals with severe hepatic impairment, uncontrolled hypotension, or those taking contraindicated strong CYP3A4 inhibitors without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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