Product image of Nimodipine Altan Pharma (Nimodipine) supplied by GNH India

Nimodipine Altan Pharma

Active Ingredient:
Nimodipine
Origin:
EU

Nimodipine Altan Pharma (Nimodipine)

Nimodipine, the active ingredient in Nimodipine Altan Pharma, is a calcium channel blocker presented as an intravenous formulation for intravenous use. It is indicated for the prevention of cerebral vasospasm following subarachnoid hemorrhage. GNH India supplies Nimodipine Altan Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Altan Pharma Ltd

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Indications & Clinical Uses

Nimodipine acts on the cerebral vasculature to prevent vasospasm after hemorrhagic events.

  • Prevention of cerebral vasospasm: reduces the incidence and severity of vasospasm following subarachnoid hemorrhage, helping to maintain cerebral blood flow.

How It Works

  • Nimodipine selectively antagonizes L‑type calcium channels in cerebral arterial smooth muscle. By inhibiting calcium influx, it causes dose‑dependent vasodilation of intracranial vessels, thereby decreasing vascular resistance and mitigating vasospasm after subarachnoid hemorrhage.

Side Effects

Nimodipine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Hypotension: transient blood pressure reduction.
  • Nausea or vomiting: gastrointestinal discomfort.
  • Flushing: warmth and redness of the skin.
  • Dizziness or vertigo: sensation of light‑headedness.
  • Peripheral edema: swelling of the extremities.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring intervention.
  • Bradycardia: abnormally slow heart rate.
  • Allergic reaction: rash, itching, or anaphylaxis.
  • Hepatic enzyme elevation: abnormal liver function tests.
  • Seizures: rare neurologic events.
  • Cardiac arrhythmias: irregular heart rhythms.

Precautions & Warnings

Use of Nimodipine requires careful clinical monitoring.

  • Blood pressure monitoring: check systolic and diastolic values before and during infusion.
  • Cardiac assessment: evaluate heart rate and rhythm, especially in patients with pre‑existing cardiac disease.
  • Liver function: assess hepatic enzymes prior to therapy and periodically thereafter.
  • Drug interactions: review concomitant medications that affect CYP3A4 metabolism.
  • Pregnancy and lactation: avoid use unless benefits clearly outweigh potential risks.
  • Store at below 25°C: keep in original packaging, protect from moisture and light.

Avoid Interactions

Nimodipine may interact with several drug classes.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., clarithromycin, ketoconazole): may increase plasma concentrations.
  • Other calcium channel blockers: additive vasodilatory effects leading to severe hypotension.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (e.g., ACE inhibitors, beta‑blockers): monitor for excessive blood pressure reduction.
  • Nitrates: combined vasodilation may cause profound hypotension.
  • Digoxin: increased risk of bradycardia.
  • Diuretics: may potentiate electrolyte disturbances.

Frequently Asked Questions

Nimodipine Altan Pharma is used to prevent cerebral vasospasm after subarachnoid hemorrhage. By dilating intracranial arteries, it helps maintain adequate blood flow to the brain and reduces the risk of ischemic complications associated with vasospasm.

Nimodipine selectively blocks L‑type calcium channels on the smooth muscle of cerebral vessels. This inhibition reduces calcium‑mediated contraction, leading to vasodilation of intracranial arteries and a decrease in vascular resistance, which mitigates vasospasm.

The dosing regimen for Nimodipine Altan Pharma is determined by the prescribing clinician based on the patient’s condition, weight, and response. Healthcare professionals set the appropriate infusion rate and duration according to clinical guidelines.

Safety data for Nimodipine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Nimodipine is a dihydropyridine calcium channel blocker with high selectivity for cerebral vessels, offering a favorable safety profile compared with non‑selective vasodilators. Its ability to cross the blood‑brain barrier makes it particularly effective for preventing vasospasm after subarachnoid hemorrhage.

Store the product at temperatures below 25 °C, in its original container, protected from moisture and light. Do not freeze. Follow standard aseptic handling procedures for intravenous preparations to maintain sterility.

Nimodipine Altan Pharma is administered intravenously under the supervision of a qualified healthcare professional. The infusion is typically given over a defined period, with continuous monitoring of blood pressure and cardiac status throughout the administration.

The most serious risks include severe hypotension, bradycardia, allergic reactions such as anaphylaxis, and rare hepatic toxicity. Prompt recognition and management of these events are essential, and patients should be monitored closely during therapy.

Patients with known hypersensitivity to nimodipine or other dihydropyridine calcium channel blockers should avoid the drug. Caution is also advised for individuals with severe hypotension, advanced heart block, or significant liver impairment, and the decision should be made by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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