Product image of Nimodipino Stadafarma (Nimodipine) supplied by GNH India

Nimodipino Stadafarma

Active Ingredient:
Nimodipine
Origin:
EU

Nimodipino Stadafarma (Nimodipine)

Nimodipine, the active ingredient in Nimodipino Stadafarma, is a calcium channel blocker of the dihydropyridine class presented as an oral tablet for oral administration. It works by selectively antagonising L‑type calcium channels in cerebral vessels, thereby reducing the risk of vasospasm after subarachnoid hemorrhage in adult patients.

GNH India supplies Nimodipino Stadafarma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory conformity across markets.

Manufacturer / TM Owner

Laboratorio Stada, S.L.

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Indications & Clinical Uses

Nimodipine acts on cerebral vasculature to prevent vasospasm following subarachnoid hemorrhage.

  • Subarachnoid hemorrhage: reduces the incidence and severity of cerebral vasospasm after aneurysmal bleed.

How It Works

  • Nimodipine selectively blocks L‑type calcium channels on vascular smooth muscle cells, especially in cerebral arteries. This inhibition decreases calcium influx, leading to relaxation of the arterial wall, vasodilation, and improved cerebral blood flow, which mitigates the development of vasospasm after subarachnoid hemorrhage.

Side Effects

Nimodipine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Headache: mild to moderate pain often reported during therapy.
  • Dizziness: sensation of light‑headedness, especially when standing quickly.
  • Hypotension: reduction in blood pressure, may cause faintness.
  • Nausea: upset stomach or urge to vomit.
  • Flushing: warm, reddened skin, usually on the face or neck.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Bradycardia: unusually slow heart rate that may be symptomatic.
  • Hepatic dysfunction: abnormal liver enzyme elevations.
  • Allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Stevens‑Johnson syndrome: severe skin and mucous membrane disorder.
  • Seizures: rare neurologic events requiring urgent care.

Precautions & Warnings

Before initiating Nimodipino Stadafarma, clinicians should consider several safety measures.

  • Blood pressure monitoring: check systolic and diastolic values regularly during therapy.
  • CYP3A4 inhibitors: avoid concomitant use with strong inhibitors to prevent excess drug exposure.
  • Hepatic impairment: use with caution in patients with liver dysfunction, adjusting dose if necessary.
  • Pregnancy and lactation: assess risk‑benefit ratio before prescribing to pregnant or nursing women.
  • Hypersensitivity: discontinue immediately if signs of allergic reaction appear.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Nimodipine can interact with several medicines, influencing its safety and effectiveness.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may raise plasma levels and increase toxicity.
  • Concurrent potent vasodilators (e.g., nitroglycerin): additive hypotensive effect can be dangerous.
  • Grapefruit juice: can elevate nimodipine concentrations, heightening adverse effects.

Moderate Interactions (Monitor Closely)

  • Other antihypertensives (beta‑blockers, ACE inhibitors): monitor blood pressure for excessive lowering.
  • Diuretics: watch electrolytes and blood pressure for synergistic effects.
  • Antiepileptic drugs (phenytoin, carbamazepine): may reduce nimodipine levels, requiring efficacy assessment.

Frequently Asked Questions

Nimodipino Stadafarma contains nimodipine, which is prescribed to prevent cerebral vasospasm in patients who have suffered a subarachnoid hemorrhage. By improving blood flow in the brain’s arteries, it helps reduce the risk of delayed ischemic neurological deficits that can follow the bleed.

Nimodipine selectively blocks L‑type calcium channels on the smooth muscle of cerebral arteries. This blockade reduces calcium entry into the cells, causing the vessels to relax and dilate. The resulting vasodilation improves cerebral perfusion and lessens the likelihood of vasospasm after a hemorrhagic event.

The appropriate dose of Nimodipino Stadafarma is determined by the prescribing clinician based on the patient’s condition, age, weight, and renal or hepatic function. Dosage regimens are individualized and should follow the prescribing information provided by the healthcare professional.

Safety data for nimodipine in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant. Healthcare providers must evaluate the risk‑benefit profile before prescribing to pregnant or nursing women.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nimodipine is the only calcium‑channel blocker specifically approved for preventing cerebral vasospasm after subarachnoid hemorrhage. Other agents, such as clazosentan or endothelin‑receptor antagonists, target different pathways and have distinct safety profiles. Nimodipine’s oral route and well‑characterised pharmacology make it a first‑line option in many guidelines.

Store Nimodipino Stadafarma at ambient temperature below 25 °C. Keep the tablets in their original packaging, protect them from moisture, heat and direct sunlight. Do not refrigerate or freeze the product, as temperature extremes can affect tablet integrity.

Nimodipino Stadafarma is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless otherwise directed by a healthcare professional. Administration timing (e.g., with or without food) follows the prescriber’s instructions.

The most serious risks include severe hypotension, bradycardia, and rare but potentially life‑threatening allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should be monitored for sudden drops in blood pressure, slow heart rate, or any signs of hypersensitivity, and medical attention should be sought immediately if they occur.

Nimodipino Stadafarma should be avoided in individuals with known hypersensitivity to nimodipine or any component of the formulation. Caution is also advised for patients with severe hepatic impairment, uncontrolled hypotension, or those taking contraindicated strong CYP3A4 inhibitors. The prescriber decides suitability on a case‑by‑case basis.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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